W. James Nelson
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View article: Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding Open
The primary cilium is a central signaling hub in cell proliferation and differentiation and is built and disassembled every cell cycle in many animal cells. Disassembly is critically important, as misregulation or delay of cilia loss leads…
View article: Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion
Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion Open
Shear forces between cells occur during global changes in multicellular organization during morphogenesis and tissue growth, yet how cells sense shear forces and propagate a response across a tissue is unknown. We found that applying exoge…
View article: Primary Cilium Disassembly in Mammalian Cells Occurs Predominantly by Whole-Cilium Shedding
Primary Cilium Disassembly in Mammalian Cells Occurs Predominantly by Whole-Cilium Shedding Open
The primary cilium is a central signaling hub in cell proliferation and differentiation, and is built and disassembled every cell cycle in most animal cells. Disassembly is critically important: misregulation or delay of disassembly leads …
View article: Cilium structure, assembly, and disassembly regulated by the cytoskeleton
Cilium structure, assembly, and disassembly regulated by the cytoskeleton Open
The cilium, once considered a vestigial structure, is a conserved, microtubule-based organelle critical for transducing extracellular chemical and mechanical signals that control cell polarity, differentiation, and proliferation. The ciliu…
View article: Adhesion to the host cell surface is sufficient to mediate<i>Listeria monocytogenes</i>entry into epithelial cells
Adhesion to the host cell surface is sufficient to mediate<i>Listeria monocytogenes</i>entry into epithelial cells Open
The intestinal epithelium is the first physiological barrier breached by the Gram-positive facultative pathogen Listeria monocytogenes during an in vivo infection. Listeria monocytogenes binds to the epithelial host cell receptor E-cadheri…
View article: Changes in E-cadherin rigidity sensing regulate cell adhesion
Changes in E-cadherin rigidity sensing regulate cell adhesion Open
Significance Mechanical cues, such as changes in rigidity (resistance to deformation) of the surrounding microenvironment, regulate cell behaviors. Integrin-based rigidity sensing has been examined extensively, but studies investigating ca…
View article: E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape
E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape Open
Significance Tissue morphogenesis requires coordinated regulation of cellular behavior through instructive signals from the local tissue environment, including mechanical forces exerted by neighboring cells. The cell–cell adhesion protein …
View article: Cell–Cell Junctions Organize Structural and Signaling Networks
Cell–Cell Junctions Organize Structural and Signaling Networks Open
Cell-cell junctions link cells to each other in tissues, and regulate tissue homeostasis in critical cell processes that include tissue barrier function, cell proliferation, and migration. Defects in cell-cell junctions give rise to a wide…
View article: Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex Open
Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the cell–cell adhesion protein E-cadherin functions as …
View article: Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction
Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction Open
Significance Injured tissues can self-heal. The healing process requires that tissue first migrate into the injury site and, upon collision with other expanding tissue fronts, switch from migration to cell–cell adhesion to seal the injury …
View article: Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis Open
Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-cate…
View article: Author response: Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis
Author response: Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Mechanical force and Wnt signali…
View article: Characterization of the Cadherin–Catenin Complex of the Sea Anemone<i>Nematostella vectensis</i>and Implications for the Evolution of Metazoan Cell–Cell Adhesion
Characterization of the Cadherin–Catenin Complex of the Sea Anemone<i>Nematostella vectensis</i>and Implications for the Evolution of Metazoan Cell–Cell Adhesion Open
The cadherin-catenin complex (CCC) mediates cell-cell adhesion in bilaterian animals by linking extracellular cadherin-based adhesions to the actin cytoskeleton. However, it is unknown whether the basic organization of the complex is conse…
View article: Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras
Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras Open
As part of the E-cadherin–β-catenin–αE-catenin complex (CCC), mammalian αE-catenin binds F-actin weakly in the absence of force, whereas cytosolic αE-catenin forms a homodimer that interacts more strongly with F-actin. It has been conclude…
View article: The mechanotransduction machinery at work at<i>adherens</i>junctions
The mechanotransduction machinery at work at<i>adherens</i>junctions Open
The shaping of a multicellular body, and the maintenance and repair of adult tissues require fine-tuning of cell adhesion responses and the transmission of mechanical load between the cell, its neighbors and the underlying extracellular ma…