James W. Thomas
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View article: Compliance With Antibiotic Prophylaxis in Hip Arthroplasty Following Neck of Femur Fractures: A Retrospective Clinical Audit Study
Compliance With Antibiotic Prophylaxis in Hip Arthroplasty Following Neck of Femur Fractures: A Retrospective Clinical Audit Study Open
View article: Routine Pharmacological Venous Thromboembolism (VTE) Prophylaxis in Lower-Limb Injuries: A Three-Year Retrospective Cross-Sectional Study and Service Evaluation
Routine Pharmacological Venous Thromboembolism (VTE) Prophylaxis in Lower-Limb Injuries: A Three-Year Retrospective Cross-Sectional Study and Service Evaluation Open
View article: Evaluating Compliance and Impact of the Sepsis Six Bundle in the Emergency Department: A Retrospective Cohort Study
Evaluating Compliance and Impact of the Sepsis Six Bundle in the Emergency Department: A Retrospective Cohort Study Open
View article: Stage 1 type 1 diabetes memory B lymphocytes transcriptionally differ from healthy controls and harbor insulin-binding specificities
Stage 1 type 1 diabetes memory B lymphocytes transcriptionally differ from healthy controls and harbor insulin-binding specificities Open
Autoreactive B cell activity defines the earliest detectable stage (Stage 1) of type 1 diabetes (T1D) but is incompletely understood, particularly for B cells reactive against the key T1D autoantigen, insulin. To test whether Stage 1 T1D B…
View article: Level of Stress and Coping Strategies among Primi Postnatal Mothers in Selected Hospital at Mangalore.
Level of Stress and Coping Strategies among Primi Postnatal Mothers in Selected Hospital at Mangalore. Open
Background: Motherhood is a period of transition, which brings a total change in the lives of women. The period after woman gives birth is a potentially stressful time during which she must face dramatic changes and new demands. Objective:…
View article: Transgene-Induced Chromosomal Rearrangement With Aberrant Human Vascular Endothelial Growth Factor at the Optic Fissure Leads to Uveal Coloboma in Mice
Transgene-Induced Chromosomal Rearrangement With Aberrant Human Vascular Endothelial Growth Factor at the Optic Fissure Leads to Uveal Coloboma in Mice Open
RICO represents a useful model for studying the pathogenesis of human coloboma.
View article: <b>Type 1 diabetes depends on CD4-driven expression of the transcriptional repressor, </b><b><i>Bcl6</i></b>
<b>Type 1 diabetes depends on CD4-driven expression of the transcriptional repressor, </b><b><i>Bcl6</i></b> Open
High-affinity islet autoantibodies predict type 1 diabetes in mice and humans and implicate germinal centers (GCs) in type 1 diabetes pathogenesis. T follicular helper (Tfh) cells are increased in type 1 diabetic individuals and alteration…
View article: <b>Type 1 diabetes depends on CD4-driven expression of the transcriptional repressor, </b><b><i>Bcl6</i></b>
<b>Type 1 diabetes depends on CD4-driven expression of the transcriptional repressor, </b><b><i>Bcl6</i></b> Open
High-affinity islet autoantibodies predict type 1 diabetes in mice and humans and implicate germinal centers (GCs) in type 1 diabetes pathogenesis. T follicular helper (Tfh) cells are increased in type 1 diabetic individuals and alteration…
View article: Zinc–Air Hearing Aid Batteries: An Analysis of Functional Performance
Zinc–Air Hearing Aid Batteries: An Analysis of Functional Performance Open
Background: The aim of this study was to evaluate the performance of three disposable hearing aid battery brands available in Wales. Hearing-impaired individuals who utilise hearing aids rely on the functionality of their devices, which is…
View article: Efficacy, tolerability, and bone density outcomes of elagolix with add-back therapy for endometriosis-associated pain: twelve months of an ongoing randomized phase 3 trial
Efficacy, tolerability, and bone density outcomes of elagolix with add-back therapy for endometriosis-associated pain: twelve months of an ongoing randomized phase 3 trial Open
Compared with placebo, elagolix with add-back therapy resulted in significant, clinically meaningful improvement in dysmenorrhea, nonmenstrual pelvic pain, and fatigue at 6 months that continued until month 12 for both dysmenorrhea and non…
View article: Ambulatory Blood Pressure Parameters Among Men With Hypogonadism Treated With Testosterone Transdermal Therapy
Ambulatory Blood Pressure Parameters Among Men With Hypogonadism Treated With Testosterone Transdermal Therapy Open
A meaningful effect of 16-week TTS treatment on 24-hour average SBP among men with hypogonadism could not be ruled out based on the study's noninferiority criterion. The magnitude of mean changes observed may not be clinically meaningful r…
View article: Integrated genomic and functional analyses of human skin–associated <i>Staphylococcus</i> reveal extensive inter- and intra-species diversity
Integrated genomic and functional analyses of human skin–associated <i>Staphylococcus</i> reveal extensive inter- and intra-species diversity Open
Human skin is stably colonized by a distinct microbiota that functions together with epidermal cells to maintain a protective physical barrier. Staphylococcus , a prominent genus of the skin microbiota, participates in colonization resista…
View article: Genomic characterization of the <i>C. tuberculostearicum</i> species complex, a prominent member of the human skin microbiome
Genomic characterization of the <i>C. tuberculostearicum</i> species complex, a prominent member of the human skin microbiome Open
Corynebacterium is a predominant genus in the skin microbiome, yet its genetic diversity on the skin is incompletely characterized and underrepresented in public databases. We investigated the distribution of Corynebacterium species on the…
View article: A genome catalog of the early-life human skin microbiome
A genome catalog of the early-life human skin microbiome Open
Background Metagenome-assembled genomes have greatly expanded the reference genomes for skin microbiome. However, the current reference genomes are largely based on samples from adults in North America and lack representation from infants …
View article: Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group
Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group Open
View article: Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes–Prone Mice
Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes–Prone Mice Open
Islet autoantibodies, including those directed at insulin, predict type 1 diabetes (T1D) in mice and humans and signal immune tolerance breach by B lymphocytes. High-affinity insulin autoantibodies and T follicular helper cell involvement …
View article: Btk Supports Autoreactive B Cell Development and Protects against Apoptosis but Is Expendable for Antigen Presentation
Btk Supports Autoreactive B Cell Development and Protects against Apoptosis but Is Expendable for Antigen Presentation Open
Bruton’s tyrosine kinase (Btk) propagates B cell signaling, and BTK inhibitors are in clinical trials for autoimmune disease. Although autoreactive B cells fail to develop in the absence of Btk, its role in mature cells is unknown. To addr…
View article: Comparative neurotranscriptomics reveal widespread species differences associated with bonding
Comparative neurotranscriptomics reveal widespread species differences associated with bonding Open
Background Pair bonding with a reproductive partner is rare among mammals but is an important feature of human social behavior. Decades of research on monogamous prairie voles ( Microtus ochrogaster ), along with comparative studies using …
View article: Genetic effects on liver chromatin accessibility identify disease regulatory variants
Genetic effects on liver chromatin accessibility identify disease regulatory variants Open
View article: Tumor-exklusive Peptide von gemeinsamen und individuellen Antigenen im HLA-Ligandom von oropharyngealen Plattenepithelkarzinomen
Tumor-exklusive Peptide von gemeinsamen und individuellen Antigenen im HLA-Ligandom von oropharyngealen Plattenepithelkarzinomen Open
Einleitung Tumor Antigene werden dem Immunsystem über Humane Leukozyten Antigene (HLA) präsentiert. Das HLA-Ligandom oropharyngealer Plattenepithelkarzinome (OPSCC) wurde bisher nicht charakterisiert. Material und Methoden: OPSCC Biopsien …
View article: Additional file 3 of Comparative neurotranscriptomics reveal widespread species differences associated with bonding
Additional file 3 of Comparative neurotranscriptomics reveal widespread species differences associated with bonding Open
Additional file 3: Supplementary Table 3. Results of DESeq2 comparison of species x time interaction in amygdala. Positive log2FoldChange values indicate higher overall expression in prairie voles and negative log2FoldChange values indicat…
View article: T–B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein
T–B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein Open
Signaling lymphocytic activation molecule–associated protein (SAP), a critical intracellular signaling molecule for T–B lymphocyte interactions, drives T follicular helper (Tfh) cell development in germinal centers (GCs). High-affinity isl…
View article: Autoreactive Preplasma Cells Break Tolerance in the Absence of Regulation by Dendritic Cells and Macrophages
Autoreactive Preplasma Cells Break Tolerance in the Absence of Regulation by Dendritic Cells and Macrophages Open
The ability to induce antibody responses to pathogens while maintaining the quiescence of autoreactive cells is an important aspect of immune tolerance. During activation of Toll-like receptor-4 (TLR4), dendritic cells (DCs) and macrophage…
View article: COVID‐19 Session
COVID‐19 Session Open
Psoriasis is a common immune-mediated inflammatory skin disease with frequent multimorbidity, and immunosuppressants are the mainstay of treatment in moderate-to-severe disease.An understanding of the impact of COVID-19 on individuals with…
View article: The Effect of Ethnicity in the Rate of Beta-Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis
The Effect of Ethnicity in the Rate of Beta-Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis Open
Objective We set forth to compare ethnicities for metabolic and immunological characteristics at the clinical diagnosis of type 1 diabetes (T1D) and assess the effect of ethnicity on beta-cell functional loss within 3 years after clinical …
View article: A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation
A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation Open
Spinal muscular atrophy (SMA) is the most common genetic disease in children. SMA is generally caused by mutations in the gene SMN1 . The survival of motor neurons (SMN) complex consists of SMN1, Gemins (2–8), and Strap/Unrip. We previousl…
View article: High‐throughput custom capture sequencing identifies novel mutations in coloboma‐associated genes: Mutation in DNA‐binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma
High‐throughput custom capture sequencing identifies novel mutations in coloboma‐associated genes: Mutation in DNA‐binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma Open
Uveal coloboma is a potentially blinding congenital ocular malformation caused by the failure of optic fissure closure during the fifth week of human gestation. We performed custom capture high-throughput screening of 38 known coloboma-ass…
View article: mTORC1 as a cell‐intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes
mTORC1 as a cell‐intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes Open
Ample evidence indicates that nutrient concentrations in extracellular milieux affect signaling mediated by environmental sensor proteins. For instance, the mechanistic target of rapamycin (mTOR) is reduced during protein malnutrition and …
View article: DNA methylation in mice is influenced by genetics as well as sex and life experience
DNA methylation in mice is influenced by genetics as well as sex and life experience Open
View article: Molecular regulation of peripheral B cells and their progeny in immunity
Molecular regulation of peripheral B cells and their progeny in immunity Open
Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have …