James Walsham
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View article: Assessment of outcomes in postaneurysmal subarachnoid bleed patients admitted to the intensive care unit utilizing the subarachnoid haemorrhage international trialist clinicoradiological prediction model for dichotomised functional outcome and mortality
Assessment of outcomes in postaneurysmal subarachnoid bleed patients admitted to the intensive care unit utilizing the subarachnoid haemorrhage international trialist clinicoradiological prediction model for dichotomised functional outcome and mortality Open
View article: Correction: Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database
Correction: Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database Open
View article: Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data
Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data Open
This target trial emulation study suggests that a liberal transfusion threshold may provide a modest survival benefit during the early course of VA-ECMO, but no benefit afterwards. Prospective studies are needed to confirm these findings, …
View article: Liberal or restrictive transfusion for veno-arterial Extracorporeal Membrane Oxygenation patients: a target trial emulation using the OBLEX study data
Liberal or restrictive transfusion for veno-arterial Extracorporeal Membrane Oxygenation patients: a target trial emulation using the OBLEX study data Open
Background: The optimal transfusion threshold for patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) remains uncertain. Methods: We used data from OBLEX (ClinicalTrials.gov: NCT03714048), an international, prosp…
View article: Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland
Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland Open
Psychiatric comorbidity is common among ICU presentations and is associated with a lower risk of death. This association is likely to be more complex than being a simple protective factor, and future research needs to further delineate how…
View article: Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial
Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial Open
View article: Correction: Presentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study
Correction: Presentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study Open
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View article: Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation
Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation Open
In adults receiving VA-ECMO in ICU, a conservative compared to a liberal oxygen strategy, did not affect the number of ICU-free days to day 28.
View article: Presentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study
Presentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study Open
View article: Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis
Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis Open
Importance Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective To evaluate whether continuous vs intermittent infusion of a β…
View article: Correction: The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections
Correction: The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections Open
View article: The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections
The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections Open
View article: Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems Open
View article: Early persistent lymphopenia and risk of death in critically ill patients with and without sepsis.
Early persistent lymphopenia and risk of death in critically ill patients with and without sepsis. Open
Purpose To determine the proportion of critically ill patients with and without sepsis who exhibit persistent lymphopenia and examine its relationship with hospital survival. Methods Database analysis of adult intensive care unit (ICU) pat…
View article: Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest
Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest Open
In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. (Funded by the National Health and Medical Resear…
View article: Statistical Analysis Plan for the Fludrocortisone Dose Response Relationship in Septic Shock (FluDReSS) trial
Statistical Analysis Plan for the Fludrocortisone Dose Response Relationship in Septic Shock (FluDReSS) trial Open
FluDReSS is an open label randomised controlled clinical trial of three different dosing regimens of fludrocortisone in critically ill patients with septic shock compared to no fludrocortisone. The primary objective is to determine whether…
View article: PREdiction and Diagnosis using Imaging and Clinical biomarkers Trial in Traumatic Brain Injury (PREDICT-TBI) study protocol: an observational, prospective, multicentre cohort study for the prediction of outcome in moderate-to-severe TBI
PREdiction and Diagnosis using Imaging and Clinical biomarkers Trial in Traumatic Brain Injury (PREDICT-TBI) study protocol: an observational, prospective, multicentre cohort study for the prediction of outcome in moderate-to-severe TBI Open
Introduction Traumatic brain injury (TBI) is a heterogeneous condition with a broad spectrum of injury severity, pathophysiological processes and variable outcomes. For moderate-to-severe TBI survivors, recovery is often protracted and out…
View article: Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study Open
View article: Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation
Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation Open
Importance Whether selective decontamination of the digestive tract (SDD) reduces mortality in critically ill patients remains uncertain. Objective To determine whether SDD reduces in-hospital mortality in critically ill adults. Design, Se…
View article: Soft collar for acute cervical spine injury immobilisation -patient experiences and outcomes: A single centre mixed methods study
Soft collar for acute cervical spine injury immobilisation -patient experiences and outcomes: A single centre mixed methods study Open
Understanding the patients' experiences informs better care management. This study suggests that soft collars are well tolerated, do not result in pressure injuries or other adverse events and are suitable for managing acute cervical spine…
View article: Improving the handover of complex trauma patients by implementing a standardised process
Improving the handover of complex trauma patients by implementing a standardised process Open
View article: Leukocyte adhesive function in Intensive Care patients with non-infectious and infectious systemic inflammation
Leukocyte adhesive function in Intensive Care patients with non-infectious and infectious systemic inflammation Open
Background: The lack of rapid and accurate diagnostic tools to distinguish infectious (known as sepsis) and non-infectious causes of inflammation in patients with systemic inflammation remains a significantly unmet clinic need, particularl…
View article: Case Report: Preliminary Images From an Electromagnetic Portable Brain Scanner for Diagnosis and Monitoring of Acute Stroke
Case Report: Preliminary Images From an Electromagnetic Portable Brain Scanner for Diagnosis and Monitoring of Acute Stroke Open
Introduction: Electromagnetic imaging is an emerging technology which promises to provide a mobile, and rapid neuroimaging modality for pre-hospital and bedside evaluation of stroke patients based on the dielectric properties of the tissue…
View article: Fibrinogen Early In Severe Trauma studY (FEISTY): results from an Australian multicentre randomised controlled pilot trial
Fibrinogen Early In Severe Trauma studY (FEISTY): results from an Australian multicentre randomised controlled pilot trial Open
View article: Prognostic value of early leukocyte fluctuations for recovery from traumatic spinal cord injury
Prognostic value of early leukocyte fluctuations for recovery from traumatic spinal cord injury Open
Background Acute traumatic spinal cord injury (SCI) induces a systemic immune response involving circulating white blood cells (WBCs). How this response is influenced by overall trauma severity, the neurological level of injury and/or corr…
View article: Low volume ECMO results study
Low volume ECMO results study Open
View article: Prognostic value of early leukocyte fluctuations for recovery from traumatic spinal cord injury
Prognostic value of early leukocyte fluctuations for recovery from traumatic spinal cord injury Open
Background Acute traumatic spinal cord injury (SCI) induces a systemic immune response involving circulating white blood cells (WBC). How this response is influenced by overall trauma severity, the neurological level of injury and/or corre…
View article: Effect of in-bed cycling on acute muscle wasting in critically ill adults: A randomised clinical trial
Effect of in-bed cycling on acute muscle wasting in critically ill adults: A randomised clinical trial Open
View article: Acceptability, safety, and feasibility of in-bed cycling with critically ill patients
Acceptability, safety, and feasibility of in-bed cycling with critically ill patients Open
View article: Continuous renal replacement therapy and its impact on hyperammonaemia in acute liver failure
Continuous renal replacement therapy and its impact on hyperammonaemia in acute liver failure Open