James Widner
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View article: Cerebellar contributions to tau-mediated cognitive and behavioral dysfunction
Cerebellar contributions to tau-mediated cognitive and behavioral dysfunction Open
Dementia is characterized by loss of cognitive function, social deficits, and emotional impairment and is prevalent in tau-mediated disorders. However, the mechanisms underlying this cognitive and behavioral dysfunction remain uncertain, a…
View article: Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum
Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum Open
The cerebellar cortex is organized into discrete regions populated by molecularly distinct Purkinje cells (PCs), the sole cortical output neurons. While studies in animal models have shown that PC subtypes differ in their vulnerability to …
View article: Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum
Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum Open
The cerebellar cortex is organized into discrete regions populated by molecularly distinct Purkinje cells (PCs), the sole cortical output neurons. While studies in animal models have shown that PC subtypes differ in their vulnerability to …