Jamie A. Cyr
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View article: Characterizing collagen scaffold compliance with native myocardial strains using an ex-vivo cardiac model: The physio-mechanical influence of scaffold architecture and attachment method
Characterizing collagen scaffold compliance with native myocardial strains using an ex-vivo cardiac model: The physio-mechanical influence of scaffold architecture and attachment method Open
Applied to the epicardium in-vivo, regenerative cardiac patches support the ventricular wall, reduce wall stresses, encourage ventricular wall thickening, and improve ventricular function. Scaffold engraftment, however, remains a challenge…
View article: Extracellular macrostructure anisotropy improves cardiac tissue-like construct function and phenotypic cellular maturation
Extracellular macrostructure anisotropy improves cardiac tissue-like construct function and phenotypic cellular maturation Open
Regenerative cardiac tissue is a promising field of study with translational potential as a therapeutic option for myocardial repair after injury, however, poor electrical and contractile function has limited translational utility. Emergin…
View article: Complex architectural control of ice-templated collagen scaffolds using a predictive model
Complex architectural control of ice-templated collagen scaffolds using a predictive model Open
The architectural and physiomechanical properties of regenerative scaffolds have been shown to improve engineered tissue function at both a cellular and tissue level. The fabrication of regenerative three-dimensional scaffolds that precise…
View article: Genome Annotation of Novel K1 Subcluster Mycobacteriophage Blizzard
Genome Annotation of Novel K1 Subcluster Mycobacteriophage Blizzard Open
The evolution of antimicrobial resistant pathogens constitutes a significant global public health threat. Combined with the lack of incentive for pharmaceutical companies to invest in developing new antibiotics, it is clear alternative tre…
View article: Unravelling Form and Function: Improved function of engineered cardiac tissue through extra-cellular anisotropy
Unravelling Form and Function: Improved function of engineered cardiac tissue through extra-cellular anisotropy Open
Cardiac tissue engineering is a promising therapeutic option for myocardial repair after injury, however, so far engineered heart patches have shown limited translational utility due to poor electrical integration and tissue contractility.…
View article: Architectural control of ice-templated collagen scaffolds for cardiac regeneration
Architectural control of ice-templated collagen scaffolds for cardiac regeneration Open
A range of biomaterials and fabrication methods have been explored to produce biomimetic scaffolds to facilitate cardiac tissue regeneration. Ice-templated collagen scaffolds have demonstrated translational success in other clinical applic…