Jamie D. Roitman
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View article: PASTa: An Open‐Source Analysis and Signal Processing Toolbox for Fiber Photometry Data
PASTa: An Open‐Source Analysis and Signal Processing Toolbox for Fiber Photometry Data Open
Fiber photometry is a rapidly growing technique to record real‐time neural signaling in awake, behaving subjects. However, the processing and analysis of photometry data streams can be complicated, and there is wide divergence in methods a…
View article: Effects of adolescent morphine exposure on brain stimulation reward sensitivity and dopamine neuron excitability
Effects of adolescent morphine exposure on brain stimulation reward sensitivity and dopamine neuron excitability Open
Adolescent substance abuse drives lasting changes in reward processing and decision making. To determine the effects of opioid treatment and withdrawal on reward sensitivity during adolescence, we used a rate-frequency (RF) intracranial se…
View article: Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms
Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms Open
Mesolimbic dopamine encoding of non-contingent rewards and reward-predictive cues has been well established. Considerable debate remains over how mesolimbic dopamine responds to aversion and in the context of aversive conditioning. Inconsi…
View article: Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms
Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms Open
Mesolimbic dopamine encoding of non-contingent rewards and reward-predictive cues has been well established. Considerable debate remains over how mesolimbic dopamine responds to aversion and in the context of aversive conditioning. Inconsi…
View article: Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms
Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms Open
Mesolimbic dopamine encoding of non-contingent rewards and reward-predictive cues has been well established. Considerable debate remains over how mesolimbic dopamine responds to aversion and in the context of aversive conditioning. Inconsi…
View article: Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms
Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms Open
Mesolimbic dopamine encoding of non-contingent rewards and reward-predictive cues has been well established. Considerable debate remains over how mesolimbic dopamine responds to aversion and in the context of aversive conditioning. Inconsi…
View article: Effect of Voluntary Adolescent Alcohol Consumption on Encoding of Decision-Related Variables in Prefrontal Cortex
Effect of Voluntary Adolescent Alcohol Consumption on Encoding of Decision-Related Variables in Prefrontal Cortex Open
The medial and orbitofrontal regions of prefrontal cortex (PFC) have been implicated in guiding optimal behavior and updating the economic value of rewards that result from choice behaviors. Both regions mature through adolescence into ear…
View article: Thirst recruits phasic dopamine signaling through subfornical organ neurons
Thirst recruits phasic dopamine signaling through subfornical organ neurons Open
Significance The maintenance of body fluid homeostasis is critical for survival and very subtle deviations from fluid balance can prompt corrective action. These minute changes are detected by first order homeostatic neurons within circumv…
View article: Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward
Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward Open
Animal models of decision-making rely on an animal’s motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially sa…
View article: Comment on “Single-trial spike trains in parietal cortex reveal discrete steps during decision-making”
Comment on “Single-trial spike trains in parietal cortex reveal discrete steps during decision-making” Open
Latimer et al . (Reports, 10 July 2015, p. 184) claim that during perceptual decision formation, parietal neurons undergo one-time, discrete steps in firing rate instead of gradual changes that represent the accumulation of evidence. Howev…