Jamie Morris
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View article: Infantile Hepatic Hemangiomas and Hemoglobin SC Disease in a Very Low Birth Weight Premature Infant with Pulmonary Hypertension and Congestive Heart Failure: A Case of Multifactorial Etiology
Infantile Hepatic Hemangiomas and Hemoglobin SC Disease in a Very Low Birth Weight Premature Infant with Pulmonary Hypertension and Congestive Heart Failure: A Case of Multifactorial Etiology Open
Infantile hepatic hemangiomas (IHHs) are common benign tumors in infants that may have an amplifying effect leading to significant complications, particularly in the context of extreme prematurity. We are reporting a case of a 9-month-old …
View article: Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content
Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content Open
Apolipoprotein A-V (APOA5) is a critical regulator of circulating triglyceride (TG) levels. Its deletion leads to elevated plasma TG concentrations by altering the metabolism of VLDL particles in vivo. One way APOA5 exerts its effects is t…
View article: Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes
Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes Open
Transmission of vector-borne diseases can be slowed by symbionts within the secondary hosts that spread disease. Snails spread schistosomiasis, and the snail symbiont Capsaspora owczarzaki kills schistosome larvae. In studying how Capsaspo…
View article: Host lipids regulate multicellular behavior of a predator of a human pathogen
Host lipids regulate multicellular behavior of a predator of a human pathogen Open
As symbionts of animals, microbial eukaryotes benefit and harm their hosts in myriad ways. A model microeukaryote ( Capsaspora owczarzaki ) is a symbiont of Biomphalaria glabrata snails and may prevent transmission of parasitic schistosome…
View article: PPI DataHub Project Data Package: High-density Lipoprotein (HDL) Structure and Function Proteomics
PPI DataHub Project Data Package: High-density Lipoprotein (HDL) Structure and Function Proteomics Open
The purpose of this experiment was to investigate how the interactions between APOA1 and APOA2 on the surface of high-density lipoproteins (HDL) impact particle function. Interactions were investigated on HDL isolated from human blood plas…
View article: Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes
Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes Open
Plasma levels of HDL cholesterol are inversely associated with CVD progression. It is becoming increasingly clear that HDL plays important roles in immunity that go beyond its traditionally understood roles in lipid transport. We previousl…
View article: Impaired response of memory Treg to high density lipoproteins is associated with intermediate/high cardiovascular disease risk in persons with HIV
Impaired response of memory Treg to high density lipoproteins is associated with intermediate/high cardiovascular disease risk in persons with HIV Open
Cardiovascular disease (CVD) is a leading cause of enhanced morbidity and mortality in persons with HIV (PWH) in the era of highly active antiretroviral therapy (AART). However, the underlying mechanisms are not fully understood. Regulator…
View article: Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies
Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies Open
Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on …
View article: 4-oxo-2-nonenal Adducts In HDL Are Elevated In Familial Hypercholesterolemia: Identification Of Modified Sites And Functional Consequences
4-oxo-2-nonenal Adducts In HDL Are Elevated In Familial Hypercholesterolemia: Identification Of Modified Sites And Functional Consequences Open
The lipid aldehyde 4-oxo-2-nonenal (ONE) derived from peroxidation of n-6 polyunsaturated fatty acids and generated in parallel to 4-hydroxynonenal (HNE) is a highly reactive protein crosslinker. Crosslinking of proteins in high-density li…
View article: An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding
An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding Open
Apolipoprotein (apo) A-I mediates many of the anti-atherogenic functions attributed to high density lipoprotein. Unfortunately, efforts toward a high resolution structure of full-length apoA-I have not been fruitful, although there have be…