Jamilah Abusarah
YOU?
Author Swipe
View article: A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity
A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity Open
[This corrects the article DOI: 10.1016/j.isci.2025.113314.].
View article: Mesenchymal stromal cells 2.0: thinking outside the box
Mesenchymal stromal cells 2.0: thinking outside the box Open
Mesenchymal stromal cells (MSCs) are non-hematopoietic progenitor cells that can be derived from a variety of sources including bone marrow and adipose tissues among others. MSCs are plastic adherent and easy to culture ex vivo , making th…
View article: A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity
A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity Open
Despite the recent control of COVID-19, the devastating effects caused by the 3-year pandemic highlight the importance of developing effective vaccines to rapidly address future outbreaks. The present study describes a novel Spike (Sp) pro…
View article: ARM-X: an adaptable mesenchymal stromal cell-based vaccination platform suitable for solid tumors
ARM-X: an adaptable mesenchymal stromal cell-based vaccination platform suitable for solid tumors Open
Altogether, this second-generation ARM-X vaccine represents a platform adaptable to multiple solid tumors. In addition, our data clearly allude to a direct link between AccuTOX®-mediated UPR activation and antigen cross-presentation by MSC…
View article: ARM-X: an Adaptable Mesenchymal Stromal Cell-based Vaccination Plaftorm Suitable for Solid Tumors
ARM-X: an Adaptable Mesenchymal Stromal Cell-based Vaccination Plaftorm Suitable for Solid Tumors Open
Background: In addition to triggering endosomal escape, the Accum® platform was recently reported for its ability to instill antigen cross-presentation properties in mesenchymal stromal cells (MSCs). Despite the promising result…
View article: Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy
Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy Open
View article: Local delivery of accutox® synergises with immune-checkpoint inhibitors at disrupting tumor growth
Local delivery of accutox® synergises with immune-checkpoint inhibitors at disrupting tumor growth Open
View article: A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses
A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses Open
Mesenchymal stromal cells (MSCs) have been modified via genetic or pharmacological engineering into potent antigen-presenting cells-like capable of priming responding CD8 T cells. In this study, our screening of a variant library of Accum …
View article: An engineered Accum‐E7 protein‐based vaccine with dual anti‐cervical cancer activity
An engineered Accum‐E7 protein‐based vaccine with dual anti‐cervical cancer activity Open
Worldwide prevalence of cervical cancer decreased significantly with the use of human papilloma virus (HPV)‐targeted prophylactic vaccines. However, these multivalent antiviral vaccines are inert against established tumors, which leave pat…
View article: A Spike-Accum® Bioconjugate Protein Vaccine Confers Potent SARS-COV-2-Specific Immunity
A Spike-Accum® Bioconjugate Protein Vaccine Confers Potent SARS-COV-2-Specific Immunity Open
View article: Forced Intracellular Degradation of Xenoantigens as a Novel Modality for Cell-Based Cancer Immunotherapy
Forced Intracellular Degradation of Xenoantigens as a Novel Modality for Cell-Based Cancer Immunotherapy Open
View article: Intratumoral administration of unconjugated Accum™ impairs the growth of pre‐established solid lymphoma tumors
Intratumoral administration of unconjugated Accum™ impairs the growth of pre‐established solid lymphoma tumors Open
The Accum™ technology was initially designed to enhance the bioaccumulation of a given molecule in target cells. It does so by triggering endosomal membrane damages allowing endocytosed products to enter the cytosol, escaping the harsh env…
View article: Supplementary Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity
Supplementary Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity Open
Supplementary data.
View article: Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity
Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity Open
We report the discovery, via a unique high-throughput screening strategy, of a novel bioactive anticancer compound: Thiol Alkylating Compound Inducing Massive Apoptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic ce…
View article: Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity
Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity Open
We report the discovery, via a unique high-throughput screening strategy, of a novel bioactive anticancer compound: Thiol Alkylating Compound Inducing Massive Apoptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic ce…
View article: Supplementary Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity
Supplementary Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity Open
Supplementary data.
View article: The CIt protocol: A blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells
The CIt protocol: A blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells Open
Immunoproteasome-reprogrammed mesenchymal stromal cells (IRMs) can surpass dendritic cells at eliciting tumor-specific immunity. However, the current IRM vaccination regimen remains clinically unsuitable due to the relatively high dose of …
View article: CD146 Defines a Mesenchymal Stromal Cell Subpopulation with Enhanced Suppressive Properties
CD146 Defines a Mesenchymal Stromal Cell Subpopulation with Enhanced Suppressive Properties Open
Mesenchymal stromal cells (MSCs) are largely known for their immune-suppressive capacity, hence, their common use in the control of unwanted inflammation. However, novel concepts related to their biology, combined with the urgent need to i…
View article: Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity
Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity Open
The cross-presenting capacity of dendritic cells (DCs) can be limited by non-specific degradation during endosome maturation. To bypass this limitation, we present in this study a new Accum-based formulation designed to promote endosome-to…
View article: Humoral Immunity to Allogeneic Immunoproteasome-Expressing Mesenchymal Stromal Cells Requires Efferocytosis by Endogenous Phagocytes
Humoral Immunity to Allogeneic Immunoproteasome-Expressing Mesenchymal Stromal Cells Requires Efferocytosis by Endogenous Phagocytes Open
The extensive use of mesenchymal stromal cells (MSCs) over the last decade has revolutionized modern medicine. From the delivery of pharmacological proteins to regenerative medicine and immune modulation, these cells have proven to be high…
View article: The <i>CIt</i> Protocol: A Blueprint to Potentiate the Immunogenicity of Immunoproteasome-Reprogrammed Mesenchymal Stromal Cells
The <i>CIt</i> Protocol: A Blueprint to Potentiate the Immunogenicity of Immunoproteasome-Reprogrammed Mesenchymal Stromal Cells Open
View article: Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice Open
View article: Thymoproteasome-Expressing Mesenchymal Stromal Cells Confer Protective Anti-Tumor Immunity via Cross-Priming of Endogenous Dendritic Cells
Thymoproteasome-Expressing Mesenchymal Stromal Cells Confer Protective Anti-Tumor Immunity via Cross-Priming of Endogenous Dendritic Cells Open
Proteasomes are complex macromolecular structures existing in various forms to regulate a myriad of cellular processes. Besides degrading unwanted or misfolded proteins (proteostasis), distinct immune functions were ascribed for the immuno…
View article: Engineering a Potent Cancer Vaccine Using Immunoproteasome-Expressing Mesenchymal Stromal Cells
Engineering a Potent Cancer Vaccine Using Immunoproteasome-Expressing Mesenchymal Stromal Cells Open
View article: TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity
TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity Open
We report the discovery, via a unique high-throughput screening strategy, of a novel bioactive anticancer compound: Thiol Alkylating Compound Inducing Massive Apoptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic ce…
View article: A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties
A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties Open
Phenotypic screening is an ideal strategy for the discovery of novel bioactive molecules. Using a customized high-throughput screening (HTS) assay employing primary T lymphocytes, we screened a small library of 4,398 compounds with unknown…
View article: Mesenchymal Stem Cells Beyond Regenerative Medicine
Mesenchymal Stem Cells Beyond Regenerative Medicine Open
Mesenchymal stem cells (MSCs) are competent suitors of cellular therapy due to their therapeutic impact on tissue degeneration and immune-based pathologies. Additionally, their homing and immunomodulatory properties can be exploited in can…
View article: Thymic Rejuvenation: Are We There Yet?
Thymic Rejuvenation: Are We There Yet? Open
Vaccination is an appealing form of immunotherapy for frail senior patients. However, several studies have shown that in contrast to younger adults, older patients do not effectively respond to vaccines. This phenomenon is greatly attribut…