Jamison C. Siebart
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View article: Antigen-specific T cell immunotherapy by in vivo mRNA delivery
Antigen-specific T cell immunotherapy by in vivo mRNA delivery Open
Immunotherapy has shown promise for treating patients with autoimmune diseases or cancer, yet treatment is associated with adverse effects associated with global activation or suppression of T cell immunity. Here, we developed antigen-pres…
View article: Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators
Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators Open
Genetically encoded fluorescent indicators (GEFIs) are protein-based optogenetic tools that change their fluorescence intensity when binding specific ligands in cells and tissues. GEFI encoding DNA can be expressed in cell subtypes while m…
View article: Opto-MASS: a high-throughput engineering platform for genetically encoded fluorescent sensors enabling all-optical <i>in vivo</i> detection of monoamines and opioids
Opto-MASS: a high-throughput engineering platform for genetically encoded fluorescent sensors enabling all-optical <i>in vivo</i> detection of monoamines and opioids Open
Fluorescent sensor proteins are instrumental for detecting biological signals in vivo with high temporal accuracy and cell-type specificity. However, engineering sensors with physiological ligand sensitivity and selectivity is difficult be…