Jamshid Pourazar
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View article: Airway MMP-12 and DNA methylation in COPD: an integrative approach
Airway MMP-12 and DNA methylation in COPD: an integrative approach Open
Background In COPD, the balance between matrix metalloproteinases (MMPs) and their natural inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] is shifted towards excessive degradation, reflected in bronchoalveolar lavage (BAL) as …
View article: Acute airway inflammation following controlled biodiesel exhaust exposure in healthy subjects
Acute airway inflammation following controlled biodiesel exhaust exposure in healthy subjects Open
Background: Exposure to standard petrodiesel exhaust is linked to adverse health effects. Moreover, there is a mounting request to replace fossil-based fuels with renewable and sustainable alternatives and, therefore, rapeseed methyl ester…
View article: Reduced bronchoalveolar macrophage phagocytosis and cytotoxic effects after controlled short-term exposure to wood smoke in healthy humans.
Reduced bronchoalveolar macrophage phagocytosis and cytotoxic effects after controlled short-term exposure to wood smoke in healthy humans. Open
Background: Exposure to wood smoke has been shown to contribute to adverse respiratory health effects including airway infections, but the underlying mechanisms are yet unclear. A preceding study failed to confirm any acute inflammation or…
View article: Human exposure to diesel exhaust induces CYP1A1 expression via AhR activation without a coordinated antioxidant response
Human exposure to diesel exhaust induces CYP1A1 expression via AhR activation without a coordinated antioxidant response Open
Background Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF-κB and c-Jun, activation of mitogen activated protein kinases and increase…
View article: Chronic snus use in healthy males alters endothelial function and increases arterial stiffness
Chronic snus use in healthy males alters endothelial function and increases arterial stiffness Open
Background Snus usage is commonly touted as a safer alternative to cigarette smoking. However, recent studies have demonstrated possible adverse cardiovascular effects in chronic snus users. The present study evaluates the effects of chron…
View article: Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells
Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells Open
DNA methylation patterns in chronic pulmonary obstructive disease (COPD) might offer new insights into disease pathogenesis. To assess methylation profiles in the main COPD target organ, we performed an epigenome-wide association study on …
View article: Monocytes in sarcoidosis are potent tumour necrosis factor producers and predict disease outcome
Monocytes in sarcoidosis are potent tumour necrosis factor producers and predict disease outcome Open
Background Pulmonary sarcoidosis is an inflammatory disease characterised by granuloma formation and heterogeneous clinical outcome. Tumour necrosis factor (TNF) is a pro-inflammatory cytokine contributing to granuloma formation and high l…
View article: Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients
Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients Open
Sarcoidosis is a T-cell driven inflammatory disease characterized by granuloma formation. Mononuclear phagocytes (MNPs)—macrophages, monocytes, and dendritic cells (DCs)—are likely critical in sarcoidosis as they initiate and maintain T ce…
View article: Urban particulate matter stimulation of human dendritic cells enhances priming of naive <scp>CD</scp>8 T lymphocytes
Urban particulate matter stimulation of human dendritic cells enhances priming of naive <span>CD</span>8 T lymphocytes Open
Summary Epidemiological studies have consistently shown associations between elevated concentrations of urban particulate matter ( UPM ) air pollution and exacerbations of asthma and chronic obstructive pulmonary disease, which are both as…
View article: Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways
Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways Open
Hantaviruses infect humans via inhalation of virus-contaminated rodent excreta. Infection can cause severe disease with up to 40% mortality depending on the viral strain. The virus primarily targets the vascular endothelium without direct …
View article: Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure
Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure Open
The adverse effects of petrodiesel exhaust exposure on the cardiovascular and respiratory systems are well recognized. While biofuels such as rapeseed methyl ester (RME) biodiesel may have ecological advantages, the exhaust generated may c…