Sören J. Backhaus
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View article: Exercise‐induced out‐of‐proportion increase in afterload and impaired right ventricular contractile reserve in HFpEF
Exercise‐induced out‐of‐proportion increase in afterload and impaired right ventricular contractile reserve in HFpEF Open
Aims The pathophysiology of heart failure with preserved ejection fraction (HFpEF) includes pulmonary vascular remodelling and right ventricular (RV) involvement. We sought to investigate the significance of non‐invasive cardiovascular mag…
View article: Left ventricular global longitudinal strain adds incremental value for risk prediction in unselected clinical patients
Left ventricular global longitudinal strain adds incremental value for risk prediction in unselected clinical patients Open
Aims Deformation imaging has demonstrated incremental prognostic value compared to left ventricular ejection fraction (LVEF) in specific cardiovascular diseases; however, it remains widely underused. Consequently, we sought to investigate …
View article: Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis
Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis Open
Aims Epicardial adipose tissue (EAT) is closely associated with the development of heart failure and adverse myocardial remodelling. In patients with severe aortic valve stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR…
View article: Abnormal Left Atrial Strain by CMR Is Associated With Left Heart Disease in Patients With Pulmonary Hypertension
Abnormal Left Atrial Strain by CMR Is Associated With Left Heart Disease in Patients With Pulmonary Hypertension Open
BACKGROUND: Pulmonary hypertension (PH) is classified as precapillary, isolated postcapillary pulmonary hypertension (IpcPH), combined postcapillary and precapillary (CpcPH), or exercise PH. IpcPH associated with left heart disease can lea…
View article: Native T1 adds independent value for cardiovascular risk assessment beyond global longitudinal strain in an all-comers real-world clinical patient population
Native T1 adds independent value for cardiovascular risk assessment beyond global longitudinal strain in an all-comers real-world clinical patient population Open
Aims Deformation imaging remains underused for cardiovascular risk assessment. As tissue characterization has now been recognized as an additional assessment tool, we sought to investigate the significance of native T1 and extracellular vo…
View article: Serial cardiac magnetic resonance imaging to assess myocardial inflammation in PET-positive cardiac sarcoidosis under immunomodulatory therapy: a retrospective observational study
Serial cardiac magnetic resonance imaging to assess myocardial inflammation in PET-positive cardiac sarcoidosis under immunomodulatory therapy: a retrospective observational study Open
Objective To evaluate changes in cardiac magnetic resonance (CMR) tissue characteristics in patients with active cardiac sarcoidosis (CS) confirmed by positron emission tomography (PET)-CT undergoing immunomodulatory therapy (IMT), and to …
View article: Postoperative hydrocephalus in patients with infratentorial brain metastases may be influenced by preoperative treatment: a single-center cohort study
Postoperative hydrocephalus in patients with infratentorial brain metastases may be influenced by preoperative treatment: a single-center cohort study Open
Purpose Infratentorial brain metastases (BM), particularly those causing obstruction of the fourth ventricle, are associated with a significant risk of postoperative hydrocephalus. This complication remains poorly understood, especially re…
View article: Left ventricular deformation predicts major adverse cardiac events following acute myocardial infarction independently of afterload and ventricular–arterial coupling
Left ventricular deformation predicts major adverse cardiac events following acute myocardial infarction independently of afterload and ventricular–arterial coupling Open
Background Load dependence on left ventricular (LV) strain is under constant debate with its interference with prognostic implications remaining unclear. Consequently, we sought to investigate their interaction and prognostic value followi…
View article: Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation
Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation Open
Latent pulmonary vascular disease is a distinct feature already in the early pathophysiology of masked heart failure with preserved ejection fraction (HFpEF) and associated with reduced right ventricular (RV) functional reserve. We hypothe…
View article: Cardiovascular MRI–derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis
Cardiovascular MRI–derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis Open
Cardiac MRI–derived imaging markers demonstrated significant prognostic value in individuals with severe aortic stenosis, with right atrial strain independently predicting cardiovascular mortality and enabling identification of additional …
View article: Pathophysiological and prognostic relevance of exercise CMR-derived pulmonary artery compliance in patients with suspected diastolic dysfunction and normal right ventricular function
Pathophysiological and prognostic relevance of exercise CMR-derived pulmonary artery compliance in patients with suspected diastolic dysfunction and normal right ventricular function Open
Aims Right ventricular (RV) dysfunction has been associated with worse prognosis in patients with diastolic dysfunction, highlighting the importance of early detection. Main pulmonary artery (MPA) compliance may indicate adverse biventricu…
View article: Impact of epicardial adipose tissue and atrial functional impairment in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
Impact of epicardial adipose tissue and atrial functional impairment in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement Open
Background Recent studies outlined the additional prognostic value of atrial function in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). At the same time, increased epicardial adipose tis…
View article: Epicardial adipose tissue volumes for long-term risk stratification in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
Epicardial adipose tissue volumes for long-term risk stratification in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement Open
Background Accurate risk stratification is important to improve patient selection and outcome of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). As epicardial adipose tissue (EAT) is disc…
View article: Prognostic and diagnostic implications of impaired rest and exercise-stress left atrial compliance in heart failure with preserved ejection fraction: Insights from the HFpEF Stress Trial
Prognostic and diagnostic implications of impaired rest and exercise-stress left atrial compliance in heart failure with preserved ejection fraction: Insights from the HFpEF Stress Trial Open
Background With emerging therapies, early diagnosis of heart failure with preserved ejection fraction (HFpEF) comes to the fore. Whilst the reference standard of exercise-stress right heart catheterisation is well established, the clinical…
View article: Association of Cardiac MRI–derived Aortic Stiffness with Early Stages and Progression of Heart Failure with Preserved Ejection Fraction
Association of Cardiac MRI–derived Aortic Stiffness with Early Stages and Progression of Heart Failure with Preserved Ejection Fraction Open
Purpose To investigate if aortic stiffening as detected with cardiac MRI is an early phenomenon in the development and progression of heart failure with preserved ejection fraction (HFpEF). Materials and Methods Both clinical and preclinic…
View article: Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction
Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction Open
BACKGROUND: It remains unknown to what extent intrinsic atrial cardiomyopathy or left ventricular diastolic dysfunction drive atrial remodeling and functional failure in heart failure with preserved ejection fraction (HFpEF). Computational…
View article: Comprehensive characterization of cardiac contraction for improved post-infarction risk assessment
Comprehensive characterization of cardiac contraction for improved post-infarction risk assessment Open
This study aims at identifying risk-related patterns of left ventricular contraction dynamics via novel volume transient characterization. A multicenter cohort of AMI survivors (n = 1021) who underwent Cardiac Magnetic Resonance (CMR) afte…
View article: High-resolution free-breathing automated quantitative myocardial perfusion by cardiovascular magnetic resonance for the detection of functionally significant coronary artery disease
High-resolution free-breathing automated quantitative myocardial perfusion by cardiovascular magnetic resonance for the detection of functionally significant coronary artery disease Open
Aims Current assessment of myocardial ischaemia from stress perfusion cardiovascular magnetic resonance (SP-CMR) largely relies on visual interpretation. This study investigated the use of high-resolution free-breathing SP-CMR with automat…