Ján Balko
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View article: Pathologists’ experience and routine practice in high-volume lung transplant centers: An international survey
Pathologists’ experience and routine practice in high-volume lung transplant centers: An international survey Open
Lung allograft pathology encompasses a wide spectrum of disorders, with new entities and emerging diagnostic technologies. The main goal of this study was to document pathologists' current global practices and highlight areas of consensus …
View article: Transgender men as uterus donors for transplantation: A theoretical perspective
Transgender men as uterus donors for transplantation: A theoretical perspective Open
Approximately 25 million people worldwide do not identify with the sex assigned at birth. Treatment options for gender dysphoria are multidisciplinary and include gender‐affirming hormone therapy and surgery. Uterus transplantation in wome…
View article: Spatial immunoprofiling of retroperitoneal leiomyosarcomas reveals intratumoral heterogeneity in immune cell infiltration, checkpoint molecule expression, and tertiary lymphoid structures
Spatial immunoprofiling of retroperitoneal leiomyosarcomas reveals intratumoral heterogeneity in immune cell infiltration, checkpoint molecule expression, and tertiary lymphoid structures Open
These findings highlight substantial intratumoral heterogeneity, which may contribute to the variable response to ICI therapy. As immune checkpoint molecule expression influences treatment eligibility, multiple biopsies from different tumo…
View article: Supplementary Figure S1 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Figure S1 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Training and cross-validation of the supervised segmentation of whole slide images. A. Evolution of the Area Under the receiver operating Curve (AUC) and area under the Precision/Recall (PR) curve during training of the self-supervised net…
View article: Supplementary Data S2 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Data S2 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Blinded annotations by two pathologists of HPCs. Each HPC was annotated 4 times by each pathologist based on 100 tiles drawn randomly each time from 3 different sets. The 100 tiles were randomly selected from the NYU training (twice), from…
View article: Supplementary Figure S4 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Figure S4 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Top 144 tiles from necrosis regions assigned with the highest probability as poor (row 1) or bad (row 2) outcome by the AI, and belonging to patients with poor (column 1) or bad (column 2) outcome.
View article: Supplementary Figure S6 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Figure S6 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
HPL-Atlas with annotations of HPCs by pathologists. A. For each HPC, annotations were made by two pathologists based on sets of 100 tiles randomly selected for each HPC. For the NYU dataset (left panels), two sets were drawn from the train…
View article: Supplementary Figure S3 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Figure S3 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Data distributions on the HPCs. A. Number of tiles associated with each HPC. B. Number of patients with at least 1, 5 or 50 tiles in each HPC. C. For each source institution, number of patients with at least one tile in each HPC. D. Number…
View article: Supplementary Figure S2 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Figure S2 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Supervised learning of poor vs good outcome (defined as survival beyond 3 years) from morphological features of each segmented region. 3-fold cross validation training curves after supervised learning of poor vs good 3-year survival using …
View article: Supplementary Figure S5 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Figure S5 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Top 144 tiles from tumor regions assigned with the highest probability as poor (row 1) or bad (row 2) outcome by the AI, and belonging to patients with poor (column 1) or bad (column 2) outcome.
View article: Data from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Data from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Purpose:Necrosis quantification in the neoadjuvant setting using pathology slide review is the most important validated prognostic marker in conventional osteosarcoma. Herein, we explored three deep-learning strategies on histology samples…
View article: Supplementary Data S1 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings
Supplementary Data S1 from Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings Open
Per slide discrepancy between the necrosis/tumor ratio estimated manually vs by the AI.
View article: 181P Intratumoral heterogeneity of immune infiltrate in leiomyosarcomas
181P Intratumoral heterogeneity of immune infiltrate in leiomyosarcomas Open
View article: Elevated PD-L1 and PECAM-1 as Diagnostic Biomarkers of Acute Rejection in Lung Transplantation
Elevated PD-L1 and PECAM-1 as Diagnostic Biomarkers of Acute Rejection in Lung Transplantation Open
Acute cellular rejection (ACR) frequently occurs following lung transplantation (LuTx) and represents a risk factor for the development of chronic lung allograft dysfunction (CLAD) as well as long-term survival. The histopathological diagn…
View article: Fibromyxoid aSoft Tissue Tumor With <scp>PLAG1</scp> Fusion—The First Case in an Adult Patient
Fibromyxoid aSoft Tissue Tumor With <span>PLAG1</span> Fusion—The First Case in an Adult Patient Open
With the expanding possibilities of human genome research in recent years, the number of cases of soft tissue tumors that we are able to classify into the correct subgroups and to reveal their molecular profile is increasing. Among such tu…
View article: Treatment Responses in Histologic Versus Molecular Diagnoses of Lung Rejection
Treatment Responses in Histologic Versus Molecular Diagnoses of Lung Rejection Open
Histologic evaluation of allograft biopsies after lung transplantation has several limitations, suggesting that molecular assessment using tissue transcriptomics could improve biopsy interpretation. This single-center, retrospective cohort…
View article: Novel and unusual <i>USP6</i> fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this disease
Novel and unusual <i>USP6</i> fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this disease Open
Aims The purpose of this study is to report novel and unusual USP6 fusion partners in aneurysmal bone cysts (ABCs). These findings may be useful in routine diagnostics as well as in studying the biology of USP6 -related disorders. Methods …
View article: 60P Spindle cell sarcomas with tyrosine kinase rearrangement
60P Spindle cell sarcomas with tyrosine kinase rearrangement Open
A group of spindle cell tumors with characteristic morphologic features and recurrent gene rearrangements has recently been described. Genome-wide DNA methylation profiling has emerged as a powerful tool for both robust classification of k…
View article: Surgical therapy of chronic lung allograft dysfunction
Surgical therapy of chronic lung allograft dysfunction Open
Lung transplantation has become a standardized and widely accepted treatment modality for selected end-stage lung diseases. Many factors influence the long-term survival of patients after lung transplantation. One of the most important is …
View article: Vascular supply of postresection pancreatic remnant after pancreaticoduodenectomy: A cadaveric study
Vascular supply of postresection pancreatic remnant after pancreaticoduodenectomy: A cadaveric study Open
Objectives: The vascular supply to the neck and body of the pancreas is highly variable. The dorsal pancreatic artery is the dominant artery feeding this area. The aim of this study was to describe the vascular supply of postresection panc…
View article: Utility of fine-needle aspiration biopsy (FNAB) in parotid pleomorphic adenoma diagnosis and management
Utility of fine-needle aspiration biopsy (FNAB) in parotid pleomorphic adenoma diagnosis and management Open
Ultrasound-guided FNAB is simple, accurate and valuable in the diagnosis of PA and provides results that can lead to the choice of less invasive operative treatment.
View article: Patient with composite haemangioendothelioma containing angiosarcoma-like areas in the setting of congenital lymphoedema mimicking Stewart-Treves syndrome: a case report
Patient with composite haemangioendothelioma containing angiosarcoma-like areas in the setting of congenital lymphoedema mimicking Stewart-Treves syndrome: a case report Open
Background Composite haemangioendothelioma is a rare vascular neoplasm with indolent to intermediate malignant potential. Diagnosis of this disease relays on histopathological identification of at least two different morphologically distin…
View article: Mazabraud's syndrome: A case report supported by molecular studies and review of the literature
Mazabraud's syndrome: A case report supported by molecular studies and review of the literature Open
Mazabraud's syndrome represents rare benign disorder characterized by simultaneous occurrence of fibrous dysplasia of bone and intramuscular myxomas within surrounding soft tissue. Mutations of GNAS1 gene were proven to be causative…
View article: The Hedgehog/GLI signaling pathway activates transcription of Slug (Snail2) in melanoma cells
The Hedgehog/GLI signaling pathway activates transcription of Slug (Snail2) in melanoma cells Open
In melanoma and other cancers, invasion, epithelial-to-mesenchymal transition, metastasis and cancer stem cell maintenance are regulated by transcription factors including the Snail family. Slug (Snail2) protein generally supports migratio…
View article: Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature
Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature Open
Aims This retrospective non-randomised study aims to identify new and rare fusion partners with USP6 in the setting of nodular fasciitis. It has been proven, that nodular fasciitis can harbour different variants of USP6 fusions, which can …
View article: Transbronchial Cryobiopsy vs Conventional Forceps Biopsy in Lung Transplant Recipients Multicenter Study
Transbronchial Cryobiopsy vs Conventional Forceps Biopsy in Lung Transplant Recipients Multicenter Study Open
View article: The dorsal pancreatic artery: A meta-analysis with clinical correlations
The dorsal pancreatic artery: A meta-analysis with clinical correlations Open
The dorsal pancreatic artery is present in the vast majority of cases. Its origin and branching are highly variable. Multiplicity of the dorsal pancreatic artery is infrequent.
View article: Histopathological examination of the ectocervical biopsy in non‐transplanted uteri: A study contributing to the provisional scoring system of subclinical graft rejection after uterus transplantation
Histopathological examination of the ectocervical biopsy in non‐transplanted uteri: A study contributing to the provisional scoring system of subclinical graft rejection after uterus transplantation Open
Introduction Uterus transplantation is a causal treatment for absolute uterine factor infertility. Assessing rejection signs using a histopathological examination of the ectocervical biopsy from the transplanted uterus is common practice i…
View article: Multiple organ resection for large paraganglioma − a case report
Multiple organ resection for large paraganglioma − a case report Open
Paragangliomas represent a group of neuroendocrine tumours which occur in various localizations. Most of them produce catecholamines, and in advanced cases present with typical symptoms and signs such as palpitations, headache and hyperten…
View article: The importance of surgical margins in malignant Triton tumour of the trunk and extremities
The importance of surgical margins in malignant Triton tumour of the trunk and extremities Open
Malignant Triton tumour (MTT) is a rare variant of malignant peripheral nerve sheath tumour with partial rhabdomyosarcomatous differentiation. To the best of our knowledge, the importance of the surgical resection margins on the outcome of…