Jan Bobek
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View article: Polyenic Antibiotics and Other Antifungal Compounds Produced by Hemolytic Streptomyces Species
Polyenic Antibiotics and Other Antifungal Compounds Produced by Hemolytic Streptomyces Species Open
Streptomyces are of great interest in the pharmaceutical industry as they produce a plethora of secondary metabolites that act as antibacterial and antifungal agents. They may thrive on their own in the soil, or associate with other organi…
View article: 6S-Like scr3559 RNA Affects Development and Antibiotic Production in Streptomyces coelicolor
6S-Like scr3559 RNA Affects Development and Antibiotic Production in Streptomyces coelicolor Open
Regulatory RNAs control a number of physiological processes in bacterial cells. Here we report on a 6S-like RNA transcript (scr3559) that affects both development and antibiotic production in Streptomyces coelicolor. Its expression is enha…
View article: A Human Lung-Associated Streptomyces sp. TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and Modulation of Immune Response
A Human Lung-Associated Streptomyces sp. TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and Modulation of Immune Response Open
Streptomycetes, typical soil dwellers, can be detected as common colonizers of human bodies, especially the skin, the respiratory tract, the guts and the genital tract using molecular techniques. However, their clinical manifestations and …
View article: A Human Lung-Associated Streptomyces sp. TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and Modulation of Immune Response
A Human Lung-Associated Streptomyces sp. TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and Modulation of Immune Response Open
SRR9903270 and WGS VSDL00000000.
View article: Osteogenic and Angiogenic Profiles of Mandibular Bone-Forming Cells
Osteogenic and Angiogenic Profiles of Mandibular Bone-Forming Cells Open
The mandible is a tooth-bearing structure involving one of the most prominent bones of the facial region. Mesenchymal cell condensation is the first morphological sign of osteogenesis, and several studies have focused on this stage also in…
View article: DNA mapping and kinetic modeling of the HrdB regulon in<i>Streptomyces coelicolor</i>
DNA mapping and kinetic modeling of the HrdB regulon in<i>Streptomyces coelicolor</i> Open
HrdB in streptomycetes is a principal sigma factor whose deletion is lethal. This is also the reason why its regulon has not been investigated so far. To overcome experimental obstacles, for investigating the HrdB regulon, we constructed a…
View article: RNase III-Binding-mRNAs Revealed Novel Complementary Transcripts in Streptomyces
RNase III-Binding-mRNAs Revealed Novel Complementary Transcripts in Streptomyces Open
cis-Antisense RNAs (asRNAs) provide very simple and effective gene expression control due to the perfect complementarity between regulated and regulatory transcripts. In Streptomyces, the antibiotic-producing clade, the antis…
View article: Secondary Metabolites Produced during the Germination of Streptomyces coelicolor
Secondary Metabolites Produced during the Germination of Streptomyces coelicolor Open
Spore awakening is a series of actions that starts with purely physical processes and continues via the launching of gene expression and metabolic activities, eventually achieving a vegetative phase of growth. In spore-forming microorganis…
View article: A Waking Review: Old and Novel Insights into the Spore Germination in Streptomyces
A Waking Review: Old and Novel Insights into the Spore Germination in Streptomyces Open
The complex development undergone by Streptomyces encompasses transitions from vegetative mycelial forms to reproductive aerial hyphae that differentiate into chains of single-celled spores. Whereas their mycelial life - connected w…