Explanipedia

Visualizing the burden of brain tissue hypoxia and metabolic dysfunction assessed by multimodal neuromonitoring in subarachnoid hemorrhage patients: the TITAN study Open

Elisa Gouvêa Bogossian, Bavo Kempen, Michael Veldeman, Soojin Park, Verena Rass , et al. · 2025

Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT) Open

Fiona Dierksen, J Sommer, Tran Anh Tuan, Huang Lin, Stefan P. Haider , et al. · 2024

Background: Intracerebral hemorrhages (ICH) and perihematomal edema (PHE) are respective imaging markers of primary and secondary brain injury in hemorrhagic stroke. In this study, we explored the potential added value of PHE radiomic feat…

Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Goals-of-Care and Family/Surrogate Decision-Maker Data Open

Matthew Jaffa, Hannah Kirsch, Claire J. Creutzfeldt, Mary Guanci, David Y. Hwang , et al. · 2024

Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging Open

Brian L. Edlow, Varina L. Boerwinkle, Jitka Annen, Mélanie Boly, Olivia Gosseries , et al. · 2024

The list of Curing Coma Campaign Collaborators included in the Acknowledgements section has been updated. Flora Hammond, Raimund Helbok, and Naomi Niznick have been added to the list. Several spelling errors have been corrected. A revised …

Recovery of consciousness after acute brain injury: a narrative review Open

Satoshi Egawa, Jeremy Ader, Jan Claassen · 2024

Background Disorders of consciousness (DoC) are frequently encountered in both, acute and chronic brain injuries. In many countries, early withdrawal of life-sustaining treatments is common practice for these patients even though the accur…

Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group Open

Elizabeth Carroll, Caroline Der‐Nigoghossian, Ayham Alkhachroum, Brian Appavu, Emily J. Gilmore , et al. · 2024

Cognitive Motor Dissociation in Disorders of Consciousness Open

Yelena G. Bodien, Judith Allanson, Paolo Cardone, Arthur Bonhomme, Jerina Carmona , et al. · 2024

Approximately one in four participants without an observable response to commands performed a cognitive task on fMRI or EEG as compared with one in three participants with an observable response to commands. (Funded by the James S. McDonne…

Anemia From Inflammation After Intracerebral Hemorrhage and Relationships With Outcome Open

David Roh, Fernanda Carvalho Poyraz, Eric Mao, Qi Shen, Vedant Kansara , et al. · 2024

Background Baseline anemia is associated with poor intracerebral hemorrhage (ICH) outcomes. However, underlying drivers for anemia and whether anemia development after ICH impacts clinical outcomes are unknown. We hypothesized that inflamm…

Broad use of processed EEG: ready for prime time yet? Open

Frank Rasulo, Jan Claassen, Stefano Romagnoli · 2024

Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist Open

Chiara Robba, Katharina M. Busl, Jan Claassen, Michael N. Diringer, Raimund Helbok , et al. · 2024

Admission viscoelastic hemostatic assay parameters predict poor long-term intracerebral hemorrhage outcomes Open

Laura Sieh, Emma Peasley, Eric Mao, Amanda Mitchell, Gregory Heinonen , et al. · 2024

Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH‐UP Criteria Open

Mehriban Sariyeva, Noora Haghighi, Amanda Mitchell, Whitney Booker, Nils Petersen , et al. · 2024

Background Intracerebral hemorrhage (ICH) is a major cause of maternal morbidity, but its pathophysiology is poorly characterized. We investigated characteristics of pregnancy‐associated ICH (P‐ICH), compared with ICH in similar aged nonpr…

ABO blood type and thromboembolic complications after intracerebral hemorrhage: An exploratory analysis Open

Natasha Ironside, Kara Melmed, Ching‐Jen Chen, Nisha Dabhi, Setareh Salehi Omran , et al. · 2024

Resting-State EEG Signature of Early Consciousness Recovery in Comatose Traumatic Brain Injury Patients Open

Ayham Alkhachroum, Emilia Fló, Brian Manolovitz, Holly M. Stradecki-Cohan, Berje Shammassian , et al. · 2024

Background Resting-state electroencephalogram (rsEEG) is usually obtained to assess seizures in comatose patients with traumatic brain injury (TBI) patients. We aim to investigate rsEEG measures and their prediction of early recovery of co…

Common data elements for disorders of consciousness Open

Brian L. Edlow, Jan Claassen, José I. Suárez · 2024

Research considerations for prospective studies of patients with coma and disorders of consciousness Open

Lorenzo Tinti, Thomas Lawson, Erika Molteni, Daniel Kondziella, Verena Rass , et al. · 2023

Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encounte…

A generalizable physiological model for detection of Delayed Cerebral Ischemia using Federated Learning Open

Ahmed El‐Hussein, Murad Megjhani, Daniel Nametz, Miriam Weiss, Jude Savarraj , et al. · 2023

Delayed cerebral ischemia (DCI) is a complication seen in patients with subarachnoid hemorrhage stroke. It is a major predictor of poor outcomes and is detected late. Machine learning models are shown to be useful for early detection, howe…

A methodology of phenotyping ICU patients from EHR data: High-fidelity, personalized, and interpretable phenotypes estimation Open

Yanran Wang, J.N. Stroh, George Hripcsak, Cecilia C. Low Wang, Tellen D. Bennett , et al. · 2023

Suboptimal Cerebral Perfusion is Associated with Ischemia After Intracerebral Hemorrhage Open

Mohamed Ridha, Murad Megjhani, Daniel Nametz, Soon Bin Kwon, Ángela Velázquez , et al. · 2023

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data Open

Erta Beqiri, Neeraj Badjatia, Ari Ercole, Brandon Foreman, Peter Hu , et al. · 2023

Covert Tracking to Immersive Stimuli in Traumatic Brain Injury Subjects With Disorders of Consciousness Open

Gabriela Aklepi, Brian Manolovitz, Linda E. Robayo, Amin Sarafraz, Carlos Francisco Blandino , et al. · 2023

Eye tracking assessments are clinician dependent and can contribute to misclassification of coma. We investigated responsiveness to videos with and without audio in traumatic brain injury (TBI) subjects using video eye-tracking (VET). We r…

Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group Open

Elizabeth Carroll, Caroline Der‐Nigoghossian, Ayham Alkhachroum, Brian Appavu, Emily J. Gilmore , et al. · 2023

Injury patterns associated with cognitive motor dissociation Open

Eva Franzova, Qi Shen, Kevin Doyle, Justine M Chen, Jennifer Egbebike , et al. · 2023

In unconscious appearing patients with acute brain injury, wilful brain activation to motor commands without behavioural signs of command following, known as cognitive motor dissociation (CMD), is associated with functional recovery. CMD c…

ABO Blood Type and Thromboembolic Complications after Intracerebral Hemorrhage: an exploratory analysis Open

Natasha Ironside, Kara Melmed, Ching‐Jen Chen, Setareh Salehi Omran, Soojin Park , et al. · 2023

Predictors and Temporal Trends of Withdrawal of Life-Sustaining Therapy After Acute Stroke in the Florida Stroke Registry Open

Ayham Alkhachroum, Lili Zhou, Negar Asdaghi, Hannah Gardener, Hao Ying , et al. · 2023

OBJECTIVES: Temporal trends and factors associated with the withdrawal of life-sustaining therapy (WLST) after acute stroke are not well determined. DESIGN: Observational study (2008–2021). SETTING: Florida Stroke Registry (152 hospitals).…

Cognitive Motor Dissociation: Gap Analysis and Future Directions Open

Jan Claassen, Daniel Kondziella, Ayham Alkhachroum, Michael N. Diringer, Brian L. Edlow , et al. · 2023

Automatic identification of intracranial pressure waveform during external ventricular drainage clamping: segmentation via wavelet analysis Open

Murad Megjhani, Kalijah Terilli, Soon Bin Kwon, Daniel Nametz, Bennett Weinerman , et al. · 2023

Objective . The objective of this study is to develop and validate a method for automatically identifying segments of intracranial pressure (ICP) waveform data from external ventricular drainage (EVD) recordings during intermittent drainag…

Prognosis of consciousness disorders in the intensive care unit Open

Aditya Kumar, Mohamed Ridha, Jan Claassen · 2023

Red Blood Cell Transfusions Are Not Associated With Incident Complications or Poor Outcomes in Patients With Intracerebral Hemorrhage Open

Fernanda Carvalho Poyraz, Amelia K. Boehme, Azzurra Cottarelli, Lisa Eisler, Mitchell S.V. Elkind , et al. · 2023

Background Anemia is associated with poor intracerebral hemorrhage (ICH) outcomes, yet the relationship of red blood cell (RBC) transfusions to ICH complications and functional outcomes remains unclear. We investigated the impact of RBC tr…

A Deep Learning Framework for Deriving Noninvasive Intracranial Pressure Waveforms from Transcranial Doppler Open

Murad Megjhani, Kalijah Terilli, Bennett Weinerman, Daniel Nametz, Soon Bin Kwon , et al. · 2023

Increased intracranial pressure (ICP) causes disability and mortality in the neurointensive care population. Current methods for monitoring ICP are invasive. We designed a deep learning framework using a domain adversarial neural network t…

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