Jan Dernič
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View article: Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors
Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors Open
The delivery of genetically encoded fluorescent sensors via adeno-associated viral vectors (AAVs) enables the quantification of biological analytes with high spatiotemporal resolution in living animals. In this study, we expose an unreport…
View article: Engineering a Novel Probiotic Toolkit in <i>Escherichia coli</i> <i>Nissle 1917</i> for Sensing and Mitigating Gut Inflammatory Diseases
Engineering a Novel Probiotic Toolkit in <i>Escherichia coli</i> <i>Nissle 1917</i> for Sensing and Mitigating Gut Inflammatory Diseases Open
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation with no cure and limited treatment options that often have systemic side effects. In this study, we developed a target-specific system to potentially trea…
View article: Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release Open
View article: Engineering a novel probiotic toolkit in<i>Escherichia coli Nissle1917</i>for sensing and mitigating gut inflammatory diseases
Engineering a novel probiotic toolkit in<i>Escherichia coli Nissle1917</i>for sensing and mitigating gut inflammatory diseases Open
Inflammatory Bowel Disease (IBD) is characterized by chronic intestinal inflammation with no cure and limited treatment options that often have systemic side effects. In this study, we developed a target-specific system to potentially trea…
View article: Abundance-Biased Codon Diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors
Abundance-Biased Codon Diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors Open
The delivery of genetically encoded fluorescent sensors via adeno-associated viral vectors (AAVs) enables the quantification of biological analytes with high spatiotemporal resolution in living animals. In this study, we expose an unreport…
View article: Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells Open
Many physiological functions, such as cell differentiation, proliferation, muscle contraction, neurotransmission and fertilisation, are regulated by changes of Ca2+ levels. The major Ca2+ store in cells is the endopla…
View article: Sensitive multicolor indicators for monitoring norepinephrine in vivo
Sensitive multicolor indicators for monitoring norepinephrine in vivo Open
View article: Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release Open
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ acti…
View article: Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs
Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs Open
In humans, there are three paralogs of the Orai Ca2+ channel that form the core of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still under active investigation,…
View article: Author Correction: A genetically encoded sensor for in vivo imaging of orexin neuropeptides
Author Correction: A genetically encoded sensor for in vivo imaging of orexin neuropeptides Open
View article: A genetically encoded sensor for in vivo imaging of orexin neuropeptides
A genetically encoded sensor for in vivo imaging of orexin neuropeptides Open
View article: Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state
Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state Open
In humans, there are three paralogs of the Orai Ca 2+ channel, which lie at the heart of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still being actively investigated, sev…
View article: CCDC 2022976: Experimental Crystal Structure Determination
CCDC 2022976: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2022975: Experimental Crystal Structure Determination
CCDC 2022975: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2022974: Experimental Crystal Structure Determination
CCDC 2022974: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2022972: Experimental Crystal Structure Determination
CCDC 2022972: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2022973: Experimental Crystal Structure Determination
CCDC 2022973: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells
Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells Open
Calcium ions regulate a wide array of physiological functions including cell differentiation, proliferation, muscle contraction, neurotransmission, and fertilization. The endoplasmic reticulum (ER) is the major intracellular Ca2+ store and…