Jan E. Brinchmann
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View article: Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants
Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants Open
Focal lesions of articular cartilage give rise to pain and reduced joint function and may, if left untreated, lead to osteoarthritis. Implantation of in vitro generated, scaffold-free autologous cartilage discs may represent the best treat…
View article: Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells
Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells Open
Exposure to fine particulate matter (PM 2.5 ) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM 2.5 exaggerate adipose inflammation and ins…
View article: Extensive downregulation of immune gene expression by microRNA-140-3p 5′ isomiR in an in vitro model of osteoarthritis
Extensive downregulation of immune gene expression by microRNA-140-3p 5′ isomiR in an in vitro model of osteoarthritis Open
Introduction of the 5' isomiR led to downregulation of genes essential for some of the most important inflammation cascades and virtual silencing of genes responsible for antigen presentation. These observations may indicate a very promisi…
View article: Scaffold-Free Engineering of Human Cartilage Implants
Scaffold-Free Engineering of Human Cartilage Implants Open
Objective Despite new strategies in tissue engineering, cartilage repair remains a major challenge. Our aim is to treat patients with focal lesions of articular cartilage with autologous hyaline cartilage implants using a scaffold-free app…
View article: Immunological Off-Target Effects of microRNA Control Sequences.
Immunological Off-Target Effects of microRNA Control Sequences. Open
Immunological off-target effects of RNA and RNAi therapy are a considerable challenge in research and the future of RNA-therapy. Here we investigated some of the hurdles we previously encountered when transfecting mircroRNA (miRNA) control…
View article: Single-Cell RNA Sequencing of <i>In Vitro</i> Expanded Chondrocytes: MSC-Like Cells With No Evidence of Distinct Subsets
Single-Cell RNA Sequencing of <i>In Vitro</i> Expanded Chondrocytes: MSC-Like Cells With No Evidence of Distinct Subsets Open
Objective To investigate the heterogeneity of in vitro expanded chondrocytes used for autologous chondrocyte implantation. Methods Human articular chondrocytes were expanded in vitro for 14 days, sorted into 86 single cells using fluoresce…
View article: Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial
Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial Open
The BOOST-2 trial does not support the use of nucleated BMCs in patients with STEMI and moderately reduced LVEF treated according to current standards of early PCI and drug therapy.
View article: Aarhus Regenerative Orthopaedics Symposium (AROS)
Aarhus Regenerative Orthopaedics Symposium (AROS) Open
The combination of modern interventional and preventive medicine has led to an epidemic of ageing. While this phenomenon is a positive consequence of an improved lifestyle and achievements in a society, the longer life expectancy is often …
View article: Overview of the project strategy.
Overview of the project strategy. Open
Autologous pairs of mesenchymal stem/progenitor cells (MSPC) and endothelial colony-forming progenitor cells (ECFC) were isolated, purified and expanded from the same human umbilical cord as described (http://www.jove.com/author/Andreas_Re…
View article: Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO<sub>2</sub> scaffolds
Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO<sub>2</sub> scaffolds Open
The purpose of bone tissue engineering is to employ scaffolds, cells, and growth factors to facilitate healing of bone defects. The aim of this study was to assess the viability and osteogenic differentiation of primary human osteoblasts a…