Jan Ehrchen
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View article: Altered microvasculature in patients with adult-onset dermatomyositis using optical coherence tomography angiography
Altered microvasculature in patients with adult-onset dermatomyositis using optical coherence tomography angiography Open
To assess ocular microvascular vessel density (VD) in patients with adult-onset dermatomyositis (DM) measured by optical coherence tomography angiography (OCTA). 10 eyes of 10 patients with DM without interstitial lung disease were include…
View article: Microvascular Density Analysis of Patients with Trigeminal Herpes Zoster—An Optical Coherence Tomography Angiography Study
Microvascular Density Analysis of Patients with Trigeminal Herpes Zoster—An Optical Coherence Tomography Angiography Study Open
Purpose: Varicella zoster virus (VZV) vasculopathy can occur in patients with herpes zoster (HZ). Our aim was to evaluate the retinal microvascular vessel density (VD) in patients with trigeminal HZ measured by optical coherence tomography…
View article: Impact of a dermatological rehabilitation program on cardiovascular risks of psoriasis patients
Impact of a dermatological rehabilitation program on cardiovascular risks of psoriasis patients Open
Summary Background and Objectives Psoriasis vulgaris is a common chronic inflammatory skin disease, associated with multiple cardiovascular comorbidities, which can ultimately lead to increased mortality. Dermatological rehabilitation prog…
View article: Corrigendum: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<scp>EADV</scp>)
Corrigendum: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<span>EADV</span>) Open
Correction for the following article: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV)
View article: Impact of Systemic Sclerosis-Associated Interstitial Lung Disease With and Without Pulmonary Hypertension on Survival
Impact of Systemic Sclerosis-Associated Interstitial Lung Disease With and Without Pulmonary Hypertension on Survival Open
ILD is the most prevalent pulmonary involvement in SSc, whereas the combination of ILD and PH is associated with the most detrimental survival.
View article: Effects of nintedanib in patients with limited cutaneous systemic sclerosis and interstitial lung disease
Effects of nintedanib in patients with limited cutaneous systemic sclerosis and interstitial lung disease Open
Objectives To investigate the course of interstitial lung disease (ILD) and the effects of nintedanib in patients with limited cutaneous systemic sclerosis (lcSSc). Methods In the SENSCIS trial, patients with SSc-ILD were randomized to rec…
View article: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<scp>EADV</scp>)
S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<span>EADV</span>) Open
Background Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with mucocutaneous and multi‐organ involvement. PNP/PAMS is typically associated with lymphoprolifera…
View article: Anti‐DFS70 antibodies are associated with atopic dermatitis and can cause misdiagnosis of connective tissue disease
Anti‐DFS70 antibodies are associated with atopic dermatitis and can cause misdiagnosis of connective tissue disease Open
Summary Background and Objectives Antinuclear antibodies (ANA) detected by HEp2 cell immunofluorescence staining are a characteristic finding in patients with connective tissue disease (CTD). However, even detection of highly elevated ANA …
View article: Anti-acid therapy in SSc-associated interstitial lung disease: long-term outcomes from the German Network for Systemic Sclerosis
Anti-acid therapy in SSc-associated interstitial lung disease: long-term outcomes from the German Network for Systemic Sclerosis Open
Objectives Gastroesophageal reflux disease (GERD) occurs frequently in patients with SSc. We investigated whether the presence of GERD and/or the use of anti-acid therapy, specifically proton-pump inhibitors (PPIs), are associated with lon…
View article: S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid
S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid Open
Summary Mucous membrane pemphigoid (MMP) is a pemphigoid disease with predominant mucous membrane involvement. It mainly affects the mucous membranes of the mouth, eyes, nose and pharynx, but also the larynx, trachea, esophagus, genital an…
View article: <scp>UVA1</scp> radiation attenuates pro‐inflammatory functions in human monocytes
<span>UVA1</span> radiation attenuates pro‐inflammatory functions in human monocytes Open
UVA1 therapy is effective in the treatment of inflammatory and autoimmune skin diseases. The mode of action of UVA1 therapy is not completely understood and especially data on cells of the innate immune system like monocytes, which are cri…
View article: Updated<scp>S2</scp>K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (<scp>EADV</scp>)
Updated<span>S2</span>K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (<span>EADV</span>) Open
Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, general…
View article: Autologous hematopoietic stem cell transplantation improves long term survival – data from a national registry
Autologous hematopoietic stem cell transplantation improves long term survival – data from a national registry Open
Background Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc. Objectives To assess safety …
View article: Additional file 3 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans
Additional file 3 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans Open
Additional file 3. Dataset 2. Full HLA sequencing data table.
View article: Additional file 4 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans
Additional file 4 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans Open
Additional file 4. Dataset 3. HLA sequencing “conditional” analysis data list.
View article: Additional file 5 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans
Additional file 5 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans Open
Additional file 5. Dataset 4. Imputation accuracy table.
View article: Additional file 2 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans
Additional file 2 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans Open
Additional file 2. Dataset 1. Meta-analysis results data table of suggestive SNPs (-log10(p) > 5.0).
View article: Diagnostic value of laboratory parameters for the discrimination between erysipelas and limited cellulitis
Diagnostic value of laboratory parameters for the discrimination between erysipelas and limited cellulitis Open
Summary Background and objectives Erysipelas, caused by beta‐hemolytic streptococci, and limited cellulitis, frequently caused by Staphylococcus aureus or other bacteria, are skin and soft tissue infections characterized by typical clinica…
View article: Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV)
Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV) Open
Background Pemphigus encompasses a group of life‐threatening autoimmune bullous diseases characterized by blisters and erosions of the mucous membranes and skin. Before the era of immunosuppressive treatment, pemphigus was almost always fa…
View article: Older age onset of systemic sclerosis – accelerated disease progression in all disease subsets
Older age onset of systemic sclerosis – accelerated disease progression in all disease subsets Open
Objectives Systemic sclerosis is a heterogeneous, multisystem disease. It can occur at any age, but most patients develop the disease between the age of 40 to 50 years. There is controversial evidence on whether/how the age at disease onse…
View article: Diagnosis and management of cold urticaria in cryoablation of atrial fibrillation: a case report
Diagnosis and management of cold urticaria in cryoablation of atrial fibrillation: a case report Open
Background Cold-induced urticaria is triggered by exposure to local or environmental cold and manifests as localized or systemic pruritic papules, sometimes accompanied by angio-oedema and anaphylaxis representing a life-threatening condit…
View article: Diagnostic Value of Laboratory Parameters for Distinguishing Between Herpes Zoster and Bacterial Superficial Skin and Soft Tissue Infections
Diagnostic Value of Laboratory Parameters for Distinguishing Between Herpes Zoster and Bacterial Superficial Skin and Soft Tissue Infections Open
Clinical differentiation between herpes zoster and bacterial superficial skin and soft tissue infections of the face can be difficult. In addition, diagnosis can be complicated by bacterial superinfection of lesional herpes zoster. The aim…
View article: Aryl Hydrocarbon Receptor-Signaling Regulates Early Leishmania major-Induced Cytokine Expression
Aryl Hydrocarbon Receptor-Signaling Regulates Early Leishmania major-Induced Cytokine Expression Open
The early inflammatory skin micromilieu affects resistance in experimental infection with Leishmania major. We pursue the concept that macrophages, which take up parasites during early infection, exert decisive influence on the inflammator…
View article: More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages
More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages Open
Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms of inflammatory resolution. Glucocorticoids (GCs) are still t…