Gert-Jan Godeke
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View article: Ambler class C-type β-lactamases in<i>Enterobacter</i>spp. and<i>Klebsiella aerogenes</i>in the Netherlands, 2012-2023
Ambler class C-type β-lactamases in<i>Enterobacter</i>spp. and<i>Klebsiella aerogenes</i>in the Netherlands, 2012-2023 Open
We investigated the genomic epidemiology of Ambler class C (AmpC-type) β-lactamases in Enterobacter spp. and Klebsiella aerogenes in the national carbapenemase-producing Enterobacterales (CPE) surveillance of the Netherlands between 2012 a…
View article: Differential susceptibility of geographically distinct <i>Ixodes ricinus</i> populations to tick-borne encephalitis virus and louping ill virus
Differential susceptibility of geographically distinct <i>Ixodes ricinus</i> populations to tick-borne encephalitis virus and louping ill virus Open
Tick-borne encephalitis virus (TBEV) is an emerging pathogen in the Netherlands. Multiple divergent viral strains are circulating and the focal distribution of TBEV remains poorly understood. This may, however, be explained by differences …
View article: Multiplex Serology for Sensitive and Specific Flavivirus IgG Detection: Addition of Envelope Protein Domain III to NS1 Increases Sensitivity for Tick-Borne Encephalitis Virus IgG Detection
Multiplex Serology for Sensitive and Specific Flavivirus IgG Detection: Addition of Envelope Protein Domain III to NS1 Increases Sensitivity for Tick-Borne Encephalitis Virus IgG Detection Open
Tick-borne encephalitis is a vaccine-preventable disease of concern for public health in large parts of Europe, with EU notification rates increasing since 2018. It is caused by the orthoflavivirus tick-borne encephalitis virus (TBEV) and …
View article: Clinical and serological characteristics of symptomatic infection with seasonal human coronaviruses OC43, HKU1, NL63, and 229E in community-dwelling older adults
Clinical and serological characteristics of symptomatic infection with seasonal human coronaviruses OC43, HKU1, NL63, and 229E in community-dwelling older adults Open
Introduction Respiratory infections are a common cause of illness in older adults, potentially resulting in severe morbidity or mortality. While up to 10% of respiratory infections in this population are caused by one of the four human cor…
View article: Rescue and in vitro characterization of a divergent TBEV-Eu strain from the Netherlands
Rescue and in vitro characterization of a divergent TBEV-Eu strain from the Netherlands Open
Tick-borne encephalitis virus (TBEV) may cause tick-borne encephalitis (TBE), a potential life-threatening infection of the central nervous system in humans. Phylogenetically, TBEVs can be subdivided into three main subtypes, which differ …
View article: Heterologous Immune Responses of Serum IgG and Secretory IgA Against the Spike Protein of Endemic Coronaviruses During Severe COVID-19
Heterologous Immune Responses of Serum IgG and Secretory IgA Against the Spike Protein of Endemic Coronaviruses During Severe COVID-19 Open
Defining immune correlates of disease severity is important to better understand the immunopathogenesis in COVID-19. Here we made use of a protein microarray platform to detect IgG- and IgA-reactive antibodies in sera and saliva respective…
View article: SARS-CoV-2 RNA and antibody dynamics in a Dutch household study with dense sampling frame
SARS-CoV-2 RNA and antibody dynamics in a Dutch household study with dense sampling frame Open
This study investigated the dynamics of SARS-CoV-2 infection and diagnostics in household members of different ages and with different symptom severity after SARS-CoV-2 exposure during the early phase of the pandemic. Households with a SAR…
View article: Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination
Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination Open
Emerging SARS-CoV-2 variants pose a threat to human immunity induced by natural infection and vaccination. We assessed the recognition of three variants of concern (B.1.1.7, B.1.351 and P.1) in cohorts of COVID-19 patients ranging in disea…
View article: Validation and clinical evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test (sVNT)
Validation and clinical evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test (sVNT) Open
To understand SARS-CoV-2 immunity after natural infection or vaccination, functional assays such as virus neutralizing assays are needed. So far, assays to determine SARS-CoV-2 neutralizing antibodies rely on cell-culture based infection a…
View article: Declining SARS-CoV-2 PCR sensitivity with time and dependence on clinical features: consequences for control
Declining SARS-CoV-2 PCR sensitivity with time and dependence on clinical features: consequences for control Open
Real-time reverse transcription-polymerase chain reaction (RT-PCR) on upper respiratory tract (URT) samples is the primary method to diagnose SARS-CoV-2 infections and guide public health measures, with a supportive role for serology. Howe…
View article: Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach
Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach Open
Serology is a crucial part of the public health response to the ongoing SARS-CoV-2 pandemic. Here, we describe the development, validation and clinical evaluation of a protein micro-array as a quantitative multiplex immunoassay that can id…
View article: Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, Kenya
Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, Kenya Open
Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently identified virus causing severe viral respiratory illness in people. Little is known about the reservoir in the Horn of Africa. In Kenya, where no human MERS cases have …
View article: Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013–2014
Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013–2014 Open
We determined the presence of neutralizing antibodies to Middle East respiratory syndrome coronavirus in persons in Qatar with and without dromedary contact. Antibodies were only detected in those with contact, suggesting dromedary exposur…
View article: Spot the Difference—Development of a Syndrome Based Protein Microarray for Specific Serological Detection of Multiple Flavivirus Infections in Travelers
Spot the Difference—Development of a Syndrome Based Protein Microarray for Specific Serological Detection of Multiple Flavivirus Infections in Travelers Open
Based on these data, multiplex NS1-based protein microarray is a promising tool for surveillance and diagnosis of flaviviruses.
View article: High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014 Open
Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar sho…