Jan Grimm
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View article: Phosphatidylserine exposure and plasma membrane perforation as ferroptotic signatures for in vivo imaging
Phosphatidylserine exposure and plasma membrane perforation as ferroptotic signatures for in vivo imaging Open
Ferroptosis emerged as a cell death modality against cancer, but there are currently no available biomarkers for imaging ferroptosis-based therapies. To address this, we evaluated phosphatidylserine exposure and perforation of lipid membra…
View article: Interferon regulatory factor 8 induces intrinsic functional changes in mature neutrophils
Interferon regulatory factor 8 induces intrinsic functional changes in mature neutrophils Open
Neutrophils are the first line of host defense. Neutrophils target invading pathogens by phagocytosis, generation of reactive oxygen species (ROS), neutrophil extracellular trap formation (NETosis), and cytokine production. Interferon regu…
View article: Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System
Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System Open
Cerenkov (or Cherenkov) luminescence occurs when charged particles exceed the phase velocity of a given medium. Cerenkov as a modality has gained interest for visualization of numerous radionuclides. However, reported Cerenkov intensities …
View article: Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies
Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies Open
The cascade of events leading to tumor formation includes induction of a tumor supporting neovasculature, as a primary hallmark of cancer. Developing vasculature is difficult to evaluate in vivo but can be captured using microfluidic chip …
View article: In vivo imaging of ferroptosis through nanodynamic changes in lipid membranes
In vivo imaging of ferroptosis through nanodynamic changes in lipid membranes Open
Ferroptosis emerged as a cell death modality for drug resistant cancer cells, but there are currently no available biomarkers for imaging ferroptosis based therapies. To address this gab, we evaluated the nanodynamic changes in lipid membr…
View article: ROS‐Activatable Prodrug of Doxazolidine as Novel Cancer Therapy Paradigm
ROS‐Activatable Prodrug of Doxazolidine as Novel Cancer Therapy Paradigm Open
Overcoming severe side effects from anticancer agents without decreasing their effects on tumor growth is a major challenge. A prodrug technology is reported using agents that are spatiotemporally activated primarily in tumors while the ex…
View article: Correlated multimodal imaging in life sciences: lessons learnt
Correlated multimodal imaging in life sciences: lessons learnt Open
Correlated Multimodal Imaging (CMI) gathers information about the same specimen with two or more modalities that–combined–create a composite and complementary view of the sample (including insights into structure, function, dynamics and mo…
View article: A pan-cancer agent for screening, resection and wound monitoring via NIR and SWIR imaging
A pan-cancer agent for screening, resection and wound monitoring via NIR and SWIR imaging Open
Fluorescence guided surgery (FGS) facilitates real time tumor delineation and is being rapidly established clinically. FGS efficacy is tied to the utilized dye and provided tumor contrast over healthy tissue. Apoptosis, a cancer hallmark, …
View article: Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low-Insertion Peptide Conjugated to Indocyanine Green
Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low-Insertion Peptide Conjugated to Indocyanine Green Open
Shortwave infrared (900-1,700 nm) fluorescence imaging (SWIRFI) has shown significant advantages over visible (400-650 nm) and near-infrared (700-900 nm) fluorescence imaging (reduced autofluorescence, improved contrast, tissue resolution,…
View article: Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies
Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies Open
The cascade of events leading to tumor formation includes induction of a tumor supporting neovasculature as a primary hallmark of cancer. Developing vasculature is difficult to evaluate in vivo but can be captured using microfluidic chip t…
View article: Multiplexed PET data: (89Zr + 124I) mouse phantom - Doubles and Triple Coincidences - Inveon PET/CT scanner
Multiplexed PET data: (89Zr + 124I) mouse phantom - Doubles and Triple Coincidences - Inveon PET/CT scanner Open
Dataset from a simultaneous 89Zr and 124I PET acquisition performed with a 3D-printed mouse phantom with the preclinical PET/CT Inveon scanner. It includes: 1 ) Sinogram of Double Coincidences: With the same format as the Inveon scanner. I…
View article: Multiplexed PET data: (89Zr + 124I) mouse phantom - Doubles and Triple Coincidences - Inveon PET/CT scanner
Multiplexed PET data: (89Zr + 124I) mouse phantom - Doubles and Triple Coincidences - Inveon PET/CT scanner Open
Dataset from a simultaneous 89Zr and 124I PET acquisition performed with a 3D-printed mouse phantom with the preclinical PET/CT Inveon scanner. It includes: 1 ) Sinogram of Double Coincidences: With the same format as the Inveon scanner. I…
View article: Multiplexed PET data: (89Zr + 124I) mouse phantom - Doubles and Triple Coincidences - Inveon PET/CT scanner
Multiplexed PET data: (89Zr + 124I) mouse phantom - Doubles and Triple Coincidences - Inveon PET/CT scanner Open
Dataset from a simultaneous 89Zr and 124I PET acquisition performed with a 3D-printed mouse phantom with the preclinical PET/CT Inveon scanner. It includes: 1 ) Sinogram of Double Coincidences: With the same format as the Inveon scanner. I…
View article: Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid
Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid Open
In this phase 1 trial of the recombinant human antibody NI006 for the treatment of patients with ATTR cardiomyopathy and heart failure, the use of NI006 was associated with no apparent drug-related serious adverse events. (Funded by Neurim…
View article: Translatable Drug-Loaded Iron Oxide Nanophore Sensitizes Murine Melanoma Tumors to Monoclonal Antibody Immunotherapy
Translatable Drug-Loaded Iron Oxide Nanophore Sensitizes Murine Melanoma Tumors to Monoclonal Antibody Immunotherapy Open
Macrophages comprise a significant portion of the immune cell compartment within tumors and are known contributors to tumor pathology; however, cancer immunotherapies targeting these cells are not clinically available. The iron oxide nanop…
View article: Radiances of Cerenkov-Emitting Isotopes on the IVIS
Radiances of Cerenkov-Emitting Isotopes on the IVIS Open
Cerenkov (or Cherenkov) luminescence occurs when charged particles exceed the phase velocity of a given medium. Cerenkov has gained interest in preclinical space as well as in clinical trials for optical visualization of numerous radionucl…
View article: Multiplexed PET for true dual simultaneous and quantitative radiotracer imaging
Multiplexed PET for true dual simultaneous and quantitative radiotracer imaging Open
PET images for various mutiplexed studies using trametinib ferumoxytol, FDG, CAR-T cells labeled with iodine 124 or zirconium-89 Oxine. radiotracer characterization is also provided.
View article: Organ-on-chip systems as a model for nanomedicine
Organ-on-chip systems as a model for nanomedicine Open
Organ-on-chip systems recapitulate the form and function of biological organs in highly controlled in vitro conditions and have already been used for testing a variety of nanoparticles. Can they unlock the translational potential of nanome…
View article: Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of <i>C9orf72</i> disease
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of <i>C9orf72</i> disease Open
Hexanucleotide G 4 C 2 repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Dipeptide repeat proteins (DPRs) generated by translation of repeat-containing RNA…
View article: Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions
Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions Open
There is a critical need to improve optical imaging that will lead to its widespread acceptance for routine clinical procedures. Shortwave infrared (SWIR, 900–1700nm) imaging has demonstrated clear advantages over visible and near-infrared…