Jan Hošek
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View article: Microbial Transformation of Dietary Glycerol Contributes to Intestinal Acrolein Formation and Urinary Excretion
Microbial Transformation of Dietary Glycerol Contributes to Intestinal Acrolein Formation and Urinary Excretion Open
The aldehyde acrolein has been associated with diabetes, cardiovascular, respiratory, and neurodegenerative diseases, and gut microbiota possesses the potential for acrolein release via the key enzyme glycerol/diol dehydratase (PduCDE). Th…
View article: Megasphaera contributes to lactate-driven valerate production in the human gut
Megasphaera contributes to lactate-driven valerate production in the human gut Open
This study brings forward new mechanistic understanding on the intestinal microbial formation of the SCCA valerate. Our findings identified Megasphaera as an infrequently occurring and low abundant keystone taxon contributing to lactose/la…
View article: Novel Biological Approach to Mitigate Methane Emissions from Livestock Slurry through Microbial Conversion of Glycerol
Novel Biological Approach to Mitigate Methane Emissions from Livestock Slurry through Microbial Conversion of Glycerol Open
Pig farming is a major contributor to the emissions of greenhouse gases and pollutants. Methane (CH4), with a global warming potential 27 times that of carbon dioxide (CO2), accounts for up to 80% of the greenhouse ga…
View article: Polyphenols non-covalently bound to artificial plant cell walls are readily accessible to fecal microbiota and transiently alter fermentation activity
Polyphenols non-covalently bound to artificial plant cell walls are readily accessible to fecal microbiota and transiently alter fermentation activity Open
View article: Comparison of Swim-Up and Microfluidic Sperm Sorting Methods in Selection of Sperm for Intracytoplasmic Sperm Injection
Comparison of Swim-Up and Microfluidic Sperm Sorting Methods in Selection of Sperm for Intracytoplasmic Sperm Injection Open
The use of microfluidic sperm sorting (MFSS) systems in infertility treatment is increasing due to their practicality and ease of use. While often presented as highly effective, their efficacy in patients with varying sperm analysis result…
View article: Efficiency of sperm separation by using microfluidic chips compared to the swim up method
Efficiency of sperm separation by using microfluidic chips compared to the swim up method Open
The effectiveness of assisted reproduction methods is still not as high as was expected recently. For effective therapy, it is necessary to use only the highest quality sperm for oocyte fertilization, as the fertilization process most ofte…
View article: Managed forests are a stronghold of non‐native beetles in Europe
Managed forests are a stronghold of non‐native beetles in Europe Open
The species richness of vascular plants in forests can have contrasting effects on the occurrence of non‐native insects. The establishment of non‐native insect populations may be facilitated by low plant species richness, which reflects th…
View article: Towards an effective in-situ biodiversity assessment in European forests
Towards an effective in-situ biodiversity assessment in European forests Open
View article: Improved Synthesis of Dinuclear [M(μ‐X)(η<sup>5</sup>‐Cp*)X]<sub>2</sub> Precursors for Half‐Sandwich Complexes (M=Rh or Ir; X=Br or I)
Improved Synthesis of Dinuclear [M(μ‐X)(η<sup>5</sup>‐Cp*)X]<sub>2</sub> Precursors for Half‐Sandwich Complexes (M=Rh or Ir; X=Br or I) Open
The long‐known dinuclear complexes of the general formula [M(μ‐X)(η 5 ‐Cp*)X] 2 ( 1 – 4 ; M=Rh or Ir, X=Br or I; HCp*=pentamethylcyclopentadiene) represent important intermediates for the preparation of biologically ( e. g ., anticancer or…
View article: <i>In vitro</i> investigations on the impact of fermented dairy constituents on fecal microbiota composition and fermentation activity
<i>In vitro</i> investigations on the impact of fermented dairy constituents on fecal microbiota composition and fermentation activity Open
Fermented dairy constitutes a major dietary source and contains lactose as the main carbohydrate and living starter cultures, which can encounter the intestinal microbiota after ingestion. To investigate whether dairy-related nutritional a…
View article: Onion thiolanes as multifunctional molecules: a story about recently discovered compounds from a well-known vegetable
Onion thiolanes as multifunctional molecules: a story about recently discovered compounds from a well-known vegetable Open
Onion ( Allium cepa L.) contains various bioactive organosulfur compounds, including recently identified species with a 3,4-dimethylthiolane ring structure.
View article: Correction: Onion thiolanes as multifunctional molecules: a story about recently discovered compounds from a well-known vegetable
Correction: Onion thiolanes as multifunctional molecules: a story about recently discovered compounds from a well-known vegetable Open
Correction for ‘Onion thiolanes as multifunctional molecules: a story about recently discovered compounds from a well-known vegetable’ by Jan Hošek et al. , Food Funct. , 2025, https://doi.org/10.1039/d5fo02323h.
View article: Comparison of Swim-Up and MFSS Methods in Selection of Sperm for ICSI
Comparison of Swim-Up and MFSS Methods in Selection of Sperm for ICSI Open
Microfluidic sperm selection systems (MFSS) are increasingly being used and appear to be a promising adjunct in assisted reproductive treatment (ART). They are practical, easy to use, and often presented as highly effective. In this study,…
View article: One to rule them all? Assessing the performance of sustainable forest management indicators against multitaxonomic data for biodiversity conservation
One to rule them all? Assessing the performance of sustainable forest management indicators against multitaxonomic data for biodiversity conservation Open
http://dx.doi.org/10.13039/501100000921 European Cooperation in Science and Technology
View article: Silvicultural regime shapes understory functional structure in European forests
Silvicultural regime shapes understory functional structure in European forests Open
Managing forests to sustain their diversity and functioning is a major challenge in a changing world. Despite the key role of understory vegetation in driving forest biodiversity, regeneration and functioning, few studies address the funct…
View article: Identification of hydroxyquinazoline alkaloids from Justicia adhatoda L. leaves, a traditional natural remedy with NF-κB and AP-1-mediated anti-inflammatory properties and antioxidant activity
Identification of hydroxyquinazoline alkaloids from Justicia adhatoda L. leaves, a traditional natural remedy with NF-κB and AP-1-mediated anti-inflammatory properties and antioxidant activity Open
To the best of our knowledge, this is the first insight into the phytochemical composition of Asuro leaves from Nepal and their bioactivity. Our results will contribute to the valorisation of this medicinal species still widely used in the…
View article: Gold(I) N-Heterocyclic Carbene Complexes with 7-Azaindoles Demonstrates In Vitro Antiproliferative Effects on Ovarian Cancer Cells and Anti-inflammatory Activity
Gold(I) N-Heterocyclic Carbene Complexes with 7-Azaindoles Demonstrates In Vitro Antiproliferative Effects on Ovarian Cancer Cells and Anti-inflammatory Activity Open
The gold(I) N-heterocyclic carbene (NHC) complexes, containing a combination of 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene (iPr) and the corresponding 7-azaindole derivative (HL1–4), were prepared and characterized. The complexes of…
View article: Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes
Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes Open
A series of nine 2,3-disubstituted-quinazolin-4(3H)-one derived Schiff bases and their three Cu(II) complexes was prepared and tested for their antimicrobial activities against reference strains Staphylococcus aureus ATCC 292…
View article: Orange fruit peels from PDO varieties of Ribera (Sicily, Italy): An insight into the chemistry and bioactivity of volatile and non-volatile secondary metabolites extracted using a microwave-assisted method
Orange fruit peels from PDO varieties of Ribera (Sicily, Italy): An insight into the chemistry and bioactivity of volatile and non-volatile secondary metabolites extracted using a microwave-assisted method Open
View article: Gold(I) <i>N</i>‐heterocyclic carbene (NHC) complexes containing 6‐mercaptopurine derivatives and their in vitro anticancer and anti‐inflammatory effects
Gold(I) <i>N</i>‐heterocyclic carbene (NHC) complexes containing 6‐mercaptopurine derivatives and their in vitro anticancer and anti‐inflammatory effects Open
A series of eight N ‐heterocyclic carbenes (NHC) gold(I) complexes, involving 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene (iPr) ligand in combination with 6‐mercaptopurine derivatives (HL 1–8 ), has been prepared and thoroughly charac…
View article: Enhancing Solubility and Bioefficacy of Stilbenes by Liposomal Encapsulation─The Case of Macasiamenene F
Enhancing Solubility and Bioefficacy of Stilbenes by Liposomal Encapsulation─The Case of Macasiamenene F Open
Stilbenes in food and medicinal plants have been described as potent antiphlogistic and antioxidant compounds, and therefore, they present an interesting potential for the development of dietary supplements. Among them, macasiamenene F (MF…
View article: One to rule them all? Assessing the performance of sustainable forest management indicators against multitaxonomic data for biodiversity conservation
One to rule them all? Assessing the performance of sustainable forest management indicators against multitaxonomic data for biodiversity conservation Open
Several regional initiatives and reporting efforts assess the state of forest biodiversity through broad-scale indicators based on data from national forest inventories. Although valuable, these indicators are essentially indirect and eval…
View article: Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men
Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men Open
View article: Gold(I) N-heterocyclic Carbene Complexes with 7-Azaindoles Demonstrate <em>In Vitro</em> Antiproliferative Effects on Ovarian Cancer Cells and Anti-inflammatory Activity
Gold(I) N-heterocyclic Carbene Complexes with 7-Azaindoles Demonstrate <em>In Vitro</em> Antiproliferative Effects on Ovarian Cancer Cells and Anti-inflammatory Activity Open
The gold(I) N-heterocyclic carbene (NHC) complexes, containing a combination of 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (iPr) and the corresponding 7-azaindole derivative (HL1-4), were prepared and structurally characterized. The …
View article: Where are we now with European forest multi-taxon biodiversity and where can we head to?
Where are we now with European forest multi-taxon biodiversity and where can we head to? Open
View article: Where are we now with European forest multi-taxon biodiversity and where can we head to? - Supplementary Material
Where are we now with European forest multi-taxon biodiversity and where can we head to? - Supplementary Material Open
Supplementary material of the paper "WHERE ARE WE NOW WITH EUROPEAN FOREST MULTI-TAXON BIODIVERSITY AND WHERE CAN WE HEAD TO?"
View article: Where are we now with European forest multi-taxon biodiversity and where can we head to? - Supplementary Material
Where are we now with European forest multi-taxon biodiversity and where can we head to? - Supplementary Material Open
Supplementary material of the paper "WHERE ARE WE NOW WITH EUROPEAN FOREST MULTI-TAXON BIODIVERSITY AND WHERE CAN WE HEAD TO?"
View article: Sildenafil affects the human Kir2.1 and Kir2.2 channels at clinically relevant concentrations: Inhibition potentiated by low Ba2+
Sildenafil affects the human Kir2.1 and Kir2.2 channels at clinically relevant concentrations: Inhibition potentiated by low Ba2+ Open
Sildenafil (Viagra), the first approved and widely used oral drug for the treatment of erectile dysfunction, was occasionally associated with life-threatening ventricular arrhythmias in patients. Since inward rectifier potassium current ( …
View article: The Gold(I) Complex with Plant Hormone Kinetin Shows Promising In Vitro Anticancer and PPARγ Properties
The Gold(I) Complex with Plant Hormone Kinetin Shows Promising In Vitro Anticancer and PPARγ Properties Open
Motivated by the clinical success of gold(I) metallotherapeutic Auranofin in the effective treatment of both inflammatory and cancer diseases, we decided to prepare, characterize, and further study the [Au(kin)(PPh3)] complex (1), where Hk…
View article: Words apart: Standardizing forestry terms and definitions across European biodiversity studies
Words apart: Standardizing forestry terms and definitions across European biodiversity studies Open