Stephen Jan
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View article: Air quality targets and projected health and economic benefits in China: a modelling study (Preprint)
Air quality targets and projected health and economic benefits in China: a modelling study (Preprint) Open
BACKGROUND Air pollution continues to pose a significant health and economic burden in China, with PM2.5 concentrations remaining six times above WHO guidelines despite recent progress. OBJECTIVE This modelling study evaluates the proje…
View article: A Mixed-Methods Assessment of India’s Health Technology Assessment Ecosystem
A Mixed-Methods Assessment of India’s Health Technology Assessment Ecosystem Open
These findings emphasize the need for improvements in adherence to guidelines, transparency in topic selection, and alignment of HTA findings with policy needs. Investments in training, advanced methodology guidance, and systematic communi…
View article: Scanning the respiratory service landscape in NSW-based Aboriginal Community Controlled Health Services
Scanning the respiratory service landscape in NSW-based Aboriginal Community Controlled Health Services Open
Background Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), disproportionately impact the Aboriginal and Torres Strait Islander population of Australia. Aboriginal Community Controlled Health Services (AC…
View article: Ligamentum flavum: changes in vascular density, physical and histopathobiochemical properties in lumbar spine based on anatomical localization, spinal segment levels, and presence of lumbar spinal stenosis
Ligamentum flavum: changes in vascular density, physical and histopathobiochemical properties in lumbar spine based on anatomical localization, spinal segment levels, and presence of lumbar spinal stenosis Open
Background: Hypertrophy of the ligamentum flavum (LF) contributes significantly to the development of lumbar spinal stenosis (LSS), a serious and often disabling disease predominantly affecting the aging population. Histologic changes in t…
View article: Evaluation of Population‐Based Sodium Reduction Strategies in China: Protocol for a Study Using a Combined Quantitative and Qualitative Approach
Evaluation of Population‐Based Sodium Reduction Strategies in China: Protocol for a Study Using a Combined Quantitative and Qualitative Approach Open
Sodium intake in China is among the highest in the world, particularly in rural areas. A government‐led national sodium reduction program has been implemented but evaluations of its implementation and effectiveness remain limited. The stud…
View article: Influenza vaccination in patients with heart failure compared to usual practice: A model-based cost-effectiveness analysis
Influenza vaccination in patients with heart failure compared to usual practice: A model-based cost-effectiveness analysis Open
ChiCTR.org.cn: ChiCTR2000039081.
View article: Residential greenspace and multiple chronic health conditions in China: a cross-sectional study
Residential greenspace and multiple chronic health conditions in China: a cross-sectional study Open
Our findings underscore the potential beneficial effects of residential greenness on multiple chronic conditions, with implications for urban planning, environmental policy, and community development.
View article: Willingness to pay for assisted reproductive technologies among individuals with infertility in China
Willingness to pay for assisted reproductive technologies among individuals with infertility in China Open
Infertility, a widely prevalent condition globally, incurs high economic burdens. Assisted reproductive technologies (ARTs) are effective treatments, but public health financing in low- and middle-income countries (LMICs) rarely covers ART…
View article: Development and characterization of pegylated Fe3O4-CAPE magnetic nanoparticles for targeted therapy and hyperthermia treatment of colorectal cancer
Development and characterization of pegylated Fe3O4-CAPE magnetic nanoparticles for targeted therapy and hyperthermia treatment of colorectal cancer Open
The development of effective macromolecular drug delivery systems remains crucial for improving therapeutic outcomes in cancer treatment. This study presents the design, synthesis, and characterization of a novel polymer-modified magnetic …
View article: Effectiveness of data-driven quality improvement on hospitalizations and health outcomes for people with coronary heart disease in primary care (QUEL): a cluster randomised controlled trial with 24-month follow-up
Effectiveness of data-driven quality improvement on hospitalizations and health outcomes for people with coronary heart disease in primary care (QUEL): a cluster randomised controlled trial with 24-month follow-up Open
Background Using data to drive improved health outcomes offers an healthcare approach that has potential to benefit secondary prevention of coronary heart disease (CHD). The aim of this trial was to test the effectiveness of a data-driven …
View article: Health and economic benefits of improving pre‐hospital identification of stroke in Australian women: a modelling study
Health and economic benefits of improving pre‐hospital identification of stroke in Australian women: a modelling study Open
Objective To estimate the long term gains in life years and quality‐adjusted life years (QALYs) and the cost savings that could be achieved if ischaemic stroke was identified in women with the same level of accuracy received by men, versus…
View article: Process evaluation of a randomised trial of a triple low-dose combination pill strategy to improve hypertension control: a qualitative study
Process evaluation of a randomised trial of a triple low-dose combination pill strategy to improve hypertension control: a qualitative study Open
Background High blood pressure (BP) is a significant global health issue, with many treated patients failing to achieve BP control. The Triple Pill vs Usual Care Management for Patients with Mild-to-Moderate Hypertension (TRIUMPH) trial ev…
View article: Gendered experience of people living with type 2 diabetes in rural and urban Mexico: an ethnographic study
Gendered experience of people living with type 2 diabetes in rural and urban Mexico: an ethnographic study Open
Gender appears to substantially influence experience of living with T2D. Women were more likely to provide family support and less likely to receive it and reported greater financial barriers to care access in comparison to men. Men were m…
View article: PREVALENCE AND REASONS FOR EARLIER THAN DESIRED CESSATION OF EXCLUSIVE BREASTFEEDING (6 MONTHS) AFTER BIRTH IN MOTHERS OF THE CHILDREN ADMITTED IN OBS/PAEDS WARDS OF A PRIVATE SECTOR HOSPITAL, PESHAWAR
PREVALENCE AND REASONS FOR EARLIER THAN DESIRED CESSATION OF EXCLUSIVE BREASTFEEDING (6 MONTHS) AFTER BIRTH IN MOTHERS OF THE CHILDREN ADMITTED IN OBS/PAEDS WARDS OF A PRIVATE SECTOR HOSPITAL, PESHAWAR Open
Background: Breastfeeding is recognized globally as the most natural and beneficial way to ensure healthy growth and development in infants. Human breast milk provides all essential nutrients, antibodies, and hormones necessary for optimal…
View article: Absolute quantification of donor-derived cell-free DNA following pediatric and adult heart transplantation
Absolute quantification of donor-derived cell-free DNA following pediatric and adult heart transplantation Open
dd-cfDNA found good discrimination between cardiac recipients with and without rejection. Absolute quantification of dd-cfDNA with ddPCR is a fast and effective method to monitor graft health. Analyzing absolute dd-cfDNA levels helps ident…
View article: Post-market quality assessment of antibiotics: findings from a cross-sectional study using standardised patients in Tabalong and Bekasi districts, Indonesia
Post-market quality assessment of antibiotics: findings from a cross-sectional study using standardised patients in Tabalong and Bekasi districts, Indonesia Open
Objectives In Indonesia, antibiotics are often purchased without a prescription at community pharmacies, contrary to current regulations. This practice may increase the risk of out-of-specification (OOS) medicines being dispensed, potentia…
View article: Understanding implementation, adoption, and acceptability of the WHO package of essential noncommunicable (PEN) disease interventions in FIJI: Evidence for scale-up
Understanding implementation, adoption, and acceptability of the WHO package of essential noncommunicable (PEN) disease interventions in FIJI: Evidence for scale-up Open
The Package of Essential Noncommunicable (PEN) disease interventions in response to the high prevalence of cardiovascular diseases and diabetes was implemented in Fiji commencing in 2012. This study aimed to understand implementation outco…
View article: Establishing comprehensive anesthesia services for cancer surgery at SKMCH Peshawar: Challenges, achievements, and innovations
Establishing comprehensive anesthesia services for cancer surgery at SKMCH Peshawar: Challenges, achievements, and innovations Open
This article details the development of new anesthesia services at Shaukat Khanum Memorial Cancer Hospital and Research Center in Peshawar, Pakistan. This involved recruiting skilled staff, who were supported by intensive training. Pre-ane…
View article: Rationale and design of the TeleClinical Care Cardiac (TCC-Cardiac) trial: A pragmatic randomized trial of adjunctive virtual models of care in the secondary prevention of cardiovascular events
Rationale and design of the TeleClinical Care Cardiac (TCC-Cardiac) trial: A pragmatic randomized trial of adjunctive virtual models of care in the secondary prevention of cardiovascular events Open
Australian New Zealand Clinical Trials Registry Number ACTRN12621000754842.
View article: Establishing normative data on anterior fontanelle size: Associations with gender, mode of delivery, weight at birth, head circumference and gestational maturity
Establishing normative data on anterior fontanelle size: Associations with gender, mode of delivery, weight at birth, head circumference and gestational maturity Open
Objectives The anterior fontanelle (AF) is a fibrous gap between skull bones and is most important among all fontanelles in clinical examination of neonates and children in the first 2 years of life. There is a lack of normative data on AF…
View article: Implementation of a data-driven quality improvement program in primary care for patients with coronary heart disease: a mixed methods evaluation of acceptability, satisfaction, barriers and enablers
Implementation of a data-driven quality improvement program in primary care for patients with coronary heart disease: a mixed methods evaluation of acceptability, satisfaction, barriers and enablers Open
Background The study aimed to understand the acceptability, satisfaction, uptake, utility and feasibility of a quality improvement (QI) intervention to improve care for coronary heart disease (CHD) patients in Australian primary care pract…
View article: Modelling the health, financial protection and equity impacts of upscaling the ACT NOW early intervention breast cancer pilot program in the Philippines: an extended cost-effectiveness analysis
Modelling the health, financial protection and equity impacts of upscaling the ACT NOW early intervention breast cancer pilot program in the Philippines: an extended cost-effectiveness analysis Open
Introduction Women in the Philippines experience significant health and economic burdens of breast cancer. The Philippines has reformed financial protection for breast cancer but does not have a national early detection and treatment progr…
View article: ‘I don’t think I really realised how different the ‘new normal’ would be’—a qualitative study with cancer survivors to inform the development of survivorship centres
‘I don’t think I really realised how different the ‘new normal’ would be’—a qualitative study with cancer survivors to inform the development of survivorship centres Open
Many people experience a wide range of health and wellbeing issues after cancer, which could be addressed by various supportive care services. The purpose of this study was to identify the needs of cancer survivors and carers by exploring …
View article: Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial
Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial Open
The third, stepped-wedge, cluster-randomized, Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3), has shown that a goal-directed multi-faceted Care Bundle incorporating protocols for the mana…
View article: Statistical Analysis Plan for the Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMIST)
Statistical Analysis Plan for the Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMIST) Open
1 Abstract The OPTIMIST trial aims to determine whether low-intensity monitoring is at least as effective (“non-inferior”) to standard monitoring, on the functional recovery of patients who have received recombinant tissue plasminogen acti…