Jan Kassubek
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View article: <scp>MRI</scp> ‐ <scp>DTI</scp> Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia
<span>MRI</span> ‐ <span>DTI</span> Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia Open
Background We investigated whether diffusion tensor imaging (DTI) and atlas‐based volumetry (ABV) could track specific patterns of brain white matter (WM) microstructure and gray matter (GM) volumes in behavioral variant frontotemporal dem…
View article: Longitudinal Cerebral Structural, Microstructural, and Functional Alterations After Brain Tumor Surgery for Early Detection of Recurrent Tumors
Longitudinal Cerebral Structural, Microstructural, and Functional Alterations After Brain Tumor Surgery for Early Detection of Recurrent Tumors Open
Background: Early detection of recurrent brain tumors after malignant glioma surgery is a challenge in imaging-based assessment of glioma. Objective: The aim of this case series is to investigate whether there are signs for an improvement …
View article: Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis Open
This work was funded by Agence Nationale de la Recherche (ANR-24-CE37-4064, ANR-10-IDEX-0002, ANR-20-SFRI-0012), Fondation Thierry Latran, Association Francaise de Recherche sur la sclérose latérale amyotrophique, Association Française con…
View article: Parkinson’s disease-associated camptocormia: biopsy-confirmed focal myositis and treatment options
Parkinson’s disease-associated camptocormia: biopsy-confirmed focal myositis and treatment options Open
View article: Machine‐Learning Applications in Frontotemporal Dementia: Challenges, Prospects and Viable Clinical Applications
Machine‐Learning Applications in Frontotemporal Dementia: Challenges, Prospects and Viable Clinical Applications Open
View article: Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease
Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease Open
Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the unde…
View article: Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia
Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia Open
View article: Hypothalamus and intracranial volume segmentation at the group level by use of a Gradio-CNN framework
Hypothalamus and intracranial volume segmentation at the group level by use of a Gradio-CNN framework Open
Purpose This study aimed to develop and evaluate a graphical user interface (GUI) for the automated segmentation of the hypothalamus and intracranial volume (ICV) in brain MRI scans. The interface was designed to facilitate efficient and a…
View article: Diffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy
Diffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy Open
Background and objective A neuropathological cerebral staging concept for progressive supranuclear palsy (PSP) has been proposed that tau inclusions in PSP may progress in a sequential regional pattern. The objective was to develop a hypot…
View article: Tackling gender in progressive supranuclear palsy: Male patients present more apathy
Tackling gender in progressive supranuclear palsy: Male patients present more apathy Open
Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male a…
View article: Perioperative management of subcutaneous foslevodopa/foscarbidopa: a case report
Perioperative management of subcutaneous foslevodopa/foscarbidopa: a case report Open
View article: High Agreement Across Laboratories Between Different Alpha‐Synuclein Seed Amplification Protocols
High Agreement Across Laboratories Between Different Alpha‐Synuclein Seed Amplification Protocols Open
Background Seed amplification assays (SAA) detect alpha‐synuclein (aSYN) pathology in patient biomatrices such as cerebrospinal fluid (CSF)—potentially even before clinical manifestations. As CSF‐based SAA are approaching broader use in cl…
View article: Real-world experience with continuous subcutaneous foslevodopa/foscarbidopa infusion: insights and recommendations
Real-world experience with continuous subcutaneous foslevodopa/foscarbidopa infusion: insights and recommendations Open
View article: Joint examination of reflexive vertical saccades and small involuntary fixational saccades improves the classification of patients with progressive supranuclear palsy (PSP): a ROC study
Joint examination of reflexive vertical saccades and small involuntary fixational saccades improves the classification of patients with progressive supranuclear palsy (PSP): a ROC study Open
View article: Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging
Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging Open
Background: The clinical profiles of MNDs are dominated by inexorable motor decline, but subclinical proprioceptive, nociceptive and somatosensory deficits may also exacerbate mobility, dexterity, and bulbar function. While extra-motor pat…
View article: A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy
A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy Open
Background Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and n…
View article: Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation
Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation Open
View article: A network perspective on cognition in individuals with Parkinson's disease
A network perspective on cognition in individuals with Parkinson's disease Open
INTRODUCTION In neuropsychological diagnostics, the assignment of cognitive tests to domains is usually not empirically based. Hence, we aimed to assess the dimensionality structure of cognition in individuals with Parkinson's disease (PD)…
View article: Sub‐Microliter <scp><sup>1</sup>H</scp> Magnetic Resonance Spectroscopy for In Vivo High‐Spatial Resolution Metabolite Quantification in the Mouse Brain
Sub‐Microliter <span><sup>1</sup>H</span> Magnetic Resonance Spectroscopy for In Vivo High‐Spatial Resolution Metabolite Quantification in the Mouse Brain Open
Proton magnetic resonance spectroscopy (MRS) offers a non‐invasive, repeatable, and reproducible method for in vivo metabolite profiling of the brain and other tissues. However, metabolite fingerprinting by MRS requires high signal‐to‐nois…
View article: Insights into retention and safety/tolerability of apomorphine sublingual film in patients with Parkinson’s disease and OFF episodes: post hoc analyses of a phase III, open-label study
Insights into retention and safety/tolerability of apomorphine sublingual film in patients with Parkinson’s disease and OFF episodes: post hoc analyses of a phase III, open-label study Open
Background: Managing OFF episodes in patients with Parkinson’s disease becomes increasingly challenging over time, making it critical to tailor treatment to each patient’s needs and characteristics for effective care. Objectives: Study CTH…
View article: Advanced Neuroimaging Assessment of Neurodegenerative Dementia Syndromes: A Framework for Comprehensive Multimodal FDG-PET, MR-Perfusion, and Diffusion Analysis
Advanced Neuroimaging Assessment of Neurodegenerative Dementia Syndromes: A Framework for Comprehensive Multimodal FDG-PET, MR-Perfusion, and Diffusion Analysis Open
View article: MRI classification of progressive supranuclear palsy, Parkinson disease and controls using deep learning and machine learning algorithms for the identification of regions and tracts of interest as potential biomarkers
MRI classification of progressive supranuclear palsy, Parkinson disease and controls using deep learning and machine learning algorithms for the identification of regions and tracts of interest as potential biomarkers Open
The primary goal of the present study was to compare multiple ML-methods and a DL approach to identify the least necessary set of brain structures to classify PSP vs. controls and PSP vs. PD by ranking them in a hierarchical order of impor…
View article: 20546. CARACTERÍSTICAS BASALES ASOCIADAS AL MANTENIMIENTO DEL TRATAMIENTO CON APOMORFINA SUBLINGUAL
20546. CARACTERÍSTICAS BASALES ASOCIADAS AL MANTENIMIENTO DEL TRATAMIENTO CON APOMORFINA SUBLINGUAL Open
View article: Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology
Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology Open
View article: Lateral hypothalamus drives early-onset sleep alterations in amyotrophic lateral sclerosis
Lateral hypothalamus drives early-onset sleep alterations in amyotrophic lateral sclerosis Open
Lateral hypothalamic neurons producing melanin-concentrating hormone (MCH) and orexin/hypocretin are involved in sleep regulation. Both MCH and orexin neurons are altered in amyotrophic lateral sclerosis (ALS), the most common adult-onset …
View article: Structural parameters are superior to eigenvector centrality in detecting progressive supranuclear palsy with machine learning & multimodal MRI
Structural parameters are superior to eigenvector centrality in detecting progressive supranuclear palsy with machine learning & multimodal MRI Open
Progressive supranuclear palsy (PSP) is an atypical Parkinsonian syndrome characterized initially by falls and eye movement impairment. This multimodal imaging study aimed at eliciting structural and functional disease-specific brain alter…
View article: Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline “Parkinson’s disease” of the German Society of Neurology
Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline “Parkinson’s disease” of the German Society of Neurology Open
View article: Clinical spreading of muscle weakness in amyotrophic lateral sclerosis (ALS): a study in 910 patients
Clinical spreading of muscle weakness in amyotrophic lateral sclerosis (ALS): a study in 910 patients Open
Background Neuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS) indicates that neurodegeneration may spread corticofugally. Methods We conducted an observational study to define the initial sites of disease onset and the…
View article: Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care
Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care Open
Introduction In 2023, the German Society of Neurology published a new guideline on Parkinson’s disease. An important section dealt with PD care concepts, which represent a particularly dynamic field of PD research, including their implemen…
View article: Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson’s disease: cross-sectional and longitudinal evidence from the LANDSCAPE study
Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson’s disease: cross-sectional and longitudinal evidence from the LANDSCAPE study Open