Jan Lapins
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View article: Germline <scp><i>MC1R</i></scp> Variant Status and Efficacy of Immune Checkpoint Inhibitors in Patients With Advanced Melanoma
Germline <span><i>MC1R</i></span> Variant Status and Efficacy of Immune Checkpoint Inhibitors in Patients With Advanced Melanoma Open
The melanocortin‐1‐receptor (MC1R ) has a key role in melanocyte pigmentation regulation. Certain MC1R germline genetic variants ( R alleles) result in deficient melanin production and are associated with red hair, freckling, UV sensitivit…
View article: POT1 genetic testing in melanoma-prone families in Sweden: germline variant prevalence and tumor spectrum in identified carriers
POT1 genetic testing in melanoma-prone families in Sweden: germline variant prevalence and tumor spectrum in identified carriers Open
Background and purpose: Approximately 5–10% of cutaneous melanoma occurs in individuals with a family history of the disease. While known high-penetrance genes, such as CDKN2A, explain some cases, a substantial proportion of hereditary mel…
View article: When Are Single Reader Evaluations Insufficient in Teledermoscopic Assessments? Analyses of a Retrospective Cohort Study
When Are Single Reader Evaluations Insufficient in Teledermoscopic Assessments? Analyses of a Retrospective Cohort Study Open
Background: Teledermoscopy (TDS) emerges as an efficient tool for diagnosing skin lesions. In Sweden, double reading is the standard of care, but risk factors for misdiagnosis or mismanagement using single reader evaluations (SRE) are not …
View article: Desmoplastic melanoma in Sweden in 2009–2022: A population‐based registry study demonstrating distinctive tumour characteristics, incidence and survival trends
Desmoplastic melanoma in Sweden in 2009–2022: A population‐based registry study demonstrating distinctive tumour characteristics, incidence and survival trends Open
Background Desmoplastic melanoma (DM) is a rare subtype, accounting for less than 5% of primary cutaneous invasive melanomas. DM often arises in chronically sun‐exposed skin, in older individuals. While the incidence of cutaneous melanoma …
View article: Melanoma Incidence and Mortality Trends Among Patients Aged 59 Years or Younger in Sweden
Melanoma Incidence and Mortality Trends Among Patients Aged 59 Years or Younger in Sweden Open
Importance Over the past decades, many global regions have experienced a steady increase in the incidence of cutaneous melanoma. However, more recently, a downward trend has been observed in the younger age groups in Australia and the US. …
View article: New technology and working methods to improve healthcare for suspected malignant skin lesions: Implementation of teledermatoscopy in comprehensive healthcare
New technology and working methods to improve healthcare for suspected malignant skin lesions: Implementation of teledermatoscopy in comprehensive healthcare Open
Background Suspected malignant skin lesions are common and challenging in terms of diagnostic accuracy and lead time. Efficient use of teledermatoscopy has the potential to improve these factors. Objectives This report aims to explore the …
View article: Human-AI interaction in skin cancer diagnosis: a systematic review and meta-analysis
Human-AI interaction in skin cancer diagnosis: a systematic review and meta-analysis Open
The development of diagnostic tools for skin cancer based on artificial intelligence (AI) is increasing rapidly and will likely soon be widely implemented in clinical use. Even though the performance of these algorithms is promising in the…
View article: Long noncoding RNA plasmacytoma variant translocation 1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity
Long noncoding RNA plasmacytoma variant translocation 1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity Open
Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common and fastest increasing forms of cancer worldwide with metastatic potential. Long noncoding RNAs (lncRNAs) are a group of RNA molecules with essential regulatory …
View article: Increasing melanoma incidence and survival trend shifts with improved melanoma-specific survival between 1990 and 2020 in Sweden
Increasing melanoma incidence and survival trend shifts with improved melanoma-specific survival between 1990 and 2020 in Sweden Open
Background Melanoma-specific survival (MSS) is heterogenous between stages and is highly dependent on the T stage for primary localized disease. New systemic therapies for metastatic cutaneous melanoma (CM) have been introduced since 2012 …
View article: MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous Squamous Cell Carcinoma and Targets Ras-Related Protein RRAS2
MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous Squamous Cell Carcinoma and Targets Ras-Related Protein RRAS2 Open
Cutaneous squamous cell carcinoma (cSCC) is one of the most common types of cancer with metastatic potential. MicroRNAs regulate gene expression at the post-transcriptional level. In this study, we report that miR-23b is downregulated in c…
View article: A Novel Method Using Fine Needle Aspiration from Tumor-Draining Lymph Nodes Could Enable the Discovery of New Prognostic Markers in Patients with Cutaneous Squamous Cell Carcinoma
A Novel Method Using Fine Needle Aspiration from Tumor-Draining Lymph Nodes Could Enable the Discovery of New Prognostic Markers in Patients with Cutaneous Squamous Cell Carcinoma Open
Cutaneous squamous cell cancer (cSCC) is the second most common form of skin cancer, characterized by abnormal, accelerated growth of squamous cells. When caught early, most cSCCs are curable. About 5 percent of the cSCC cases have advance…
View article: Lead Time From First Suspicion Of Malignant Melanoma In Primary Care To Diagnostic Excision: A Cohort Study Comparing Teledermatoscopy And Traditional Referral To A Dermatology Clinic At A Tertiary Hospital
Lead Time From First Suspicion Of Malignant Melanoma In Primary Care To Diagnostic Excision: A Cohort Study Comparing Teledermatoscopy And Traditional Referral To A Dermatology Clinic At A Tertiary Hospital Open
Introduction The increasing use of teledermatoscopy in clinical practice has led to demands to evaluate the effects of this new technology on traditional healthcare systems. Objectives To study lead times from first consultation in primary…
View article: Eruptive Xanthoma as a Sign of Underlaying Severe Metabolic Disorder
Eruptive Xanthoma as a Sign of Underlaying Severe Metabolic Disorder Open
Citation: Rigolon de Lara J, Momente Miquelin G, Leocadia Fernades E, Lapis J. Eruptive Xanthoma as a Sign of Underlaying Severe Metabolic Disorder. Dermatol Pract Concept. 2023;13(1):e2023025. DOI: https://doi.org/10.5826/dpc.1301a25
View article: Melanoma‐specific survival before and after inclusion in a familial melanoma dermatologic surveillance program in <scp><i>CDKN2A</i></scp> mutation carriers and non‐carriers
Melanoma‐specific survival before and after inclusion in a familial melanoma dermatologic surveillance program in <span><i>CDKN2A</i></span> mutation carriers and non‐carriers Open
Background Inherited mutations in the CDKN2A gene are among the strongest known risk factors for cutaneous melanoma. Further, previous studies have reported inferior melanoma‐specific survival in CDKN2A mutation carriers. Objectives Here, …
View article: Trend Shifts in Age-Specific Incidence for In Situ and Invasive Cutaneous Melanoma in Sweden
Trend Shifts in Age-Specific Incidence for In Situ and Invasive Cutaneous Melanoma in Sweden Open
Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age- and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and in…
View article: The Proportion Cured of Patients with Resected Stage II–III Cutaneous Melanoma in Sweden
The Proportion Cured of Patients with Resected Stage II–III Cutaneous Melanoma in Sweden Open
Background: Cure proportion represents the proportion of patients who experience the same mortality rate as the general population and can be estimated together with the survival of the proportion experiencing excess mortality (the uncured…
View article: <i>CDKN2A</i> genetic testing in melanoma-prone families in Sweden in the years 2015–2020: implications for novel national recommendations
<i>CDKN2A</i> genetic testing in melanoma-prone families in Sweden in the years 2015–2020: implications for novel national recommendations Open
Background: Inherited pathogenic variants (PVs) in the CDKN2A gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancrea…
View article: MiR-130a Acts as a Tumor Suppressor MicroRNA in Cutaneous Squamous Cell Carcinoma and Regulates the Activity of the BMP/SMAD Pathway by Suppressing ACVR1
MiR-130a Acts as a Tumor Suppressor MicroRNA in Cutaneous Squamous Cell Carcinoma and Regulates the Activity of the BMP/SMAD Pathway by Suppressing ACVR1 Open
Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm of the skin resulting from the accumulation of somatic mutations due to solar radiation. cSCC is one of the fastest increasing malignancies, and it represents a particular pr…
View article: A growing family of outcome measurement proposals for hidradenitis suppurativa
A growing family of outcome measurement proposals for hidradenitis suppurativa Open
Linked Article: Goldfarb et al. Br J Dermatol 2021; 184:905–912.
View article: Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study
Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study Open
Background Over the past decades, many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma. Methods In this nationwide population-based stud…
View article: Survival in 31 670 patients with thin melanomas: a Swedish population‐based study*
Survival in 31 670 patients with thin melanomas: a Swedish population‐based study* Open
MSS was confirmed as excellent for patients with thin CMMs in Sweden. Although we could show a decreased MSS for patients with 0·7 mm thickness and above, the long-term survival and, in addition, a very favourable CMSS for those patients d…