Jan Larmann
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View article: Heidelberg Perioperative Deep Data Study (HeiPoDD): study protocol for a prospective cohort study for prediction of complications after high-risk non-cardiac surgery in a German university hospital
Heidelberg Perioperative Deep Data Study (HeiPoDD): study protocol for a prospective cohort study for prediction of complications after high-risk non-cardiac surgery in a German university hospital Open
Introduction Perioperative adverse events increase morbidity and mortality. The rate and severity of complications and the risk for subsequent mortality are increased after high-risk procedures and in elevated-risk patients. Over the past …
View article: Heidelberg Perioperative Deep Data Registry and Biomaterial Bank (HeiPoDD Registry and Bio Bank): study protocol for a prospective single-centre registry and biobank for patients undergoing high-risk non-cardiac surgery in a German university hospital
Heidelberg Perioperative Deep Data Registry and Biomaterial Bank (HeiPoDD Registry and Bio Bank): study protocol for a prospective single-centre registry and biobank for patients undergoing high-risk non-cardiac surgery in a German university hospital Open
Introduction Outcome after surgery depends on both patient-related as well as procedure-related risks. Complications after surgery are a significant burden to patients and to the health system. A vast amount of often unstructured data from…
View article: Telemedicine for prehospital respiratory emergencies in a retrospective quality analysis
Telemedicine for prehospital respiratory emergencies in a retrospective quality analysis Open
Respiratory distress is a common reason for emergency medical service (EMS) physicians to be prehospitally involved. While the availability of telemedical EMS systems increases continuously, there is a gap in research regarding respiratory…
View article: FAIRifying in Intensive Care: From Raw Data to HDF5 with Semantic Annotation and Data Quality Checks
FAIRifying in Intensive Care: From Raw Data to HDF5 with Semantic Annotation and Data Quality Checks Open
The heterogeneity of formats and quality levels of intensive care data represents a significant challenge for both patient treatment and scientific research. The introduction of a data format that provides unified access and a rich structu…
View article: Outcomes in patients with chronic heart failure undergoing non‐cardiac surgery: a secondary analysis of the <scp>METREPAIR</scp> international cohort study*
Outcomes in patients with chronic heart failure undergoing non‐cardiac surgery: a secondary analysis of the <span>METREPAIR</span> international cohort study* Open
Summary Introduction Heart failure is a frequent comorbidity in patients undergoing non‐cardiac surgery and an acknowledged risk factor for postoperative mortality. The associations between stable chronic heart failure and postoperative ou…
View article: Intraoperative hemodynamic management during pancreatoduodenectomy – an analysis of 525 patients
Intraoperative hemodynamic management during pancreatoduodenectomy – an analysis of 525 patients Open
Importance Optimization of perioperative hemodynamic management during major pancreatic surgery can reduce postoperative complications. Objective In this study, we aimed to investigate the effect of intraoperative hemodynamic management, i…
View article: Heme oxygenase-1 modulates CD62E-dependent endothelial cell–monocyte interactions and mitigates HLA-I-induced transplant vasculopathy in mice
Heme oxygenase-1 modulates CD62E-dependent endothelial cell–monocyte interactions and mitigates HLA-I-induced transplant vasculopathy in mice Open
The main risk factor for developing transplant vasculopathy (TV) after solid organ transplantation is de-novo production of donor-specific antibodies (DSAs) binding to endothelial cells (ECs) within the graft’s vasculature. Diverse leukocy…
View article: Visualization of Intraoperative Pancreatic Leakage (ViP): The IDEAL Stage I First-in-human, Single-arm Clinical Pilot Trial of SmartPAN
Visualization of Intraoperative Pancreatic Leakage (ViP): The IDEAL Stage I First-in-human, Single-arm Clinical Pilot Trial of SmartPAN Open
Background: The invisible fluid leaking from a partially resected pancreas is associated with complications including postoperative pancreatic fistula (POPF), calling for strategies to visualize intraoperative leakage. This single-arm, mon…
View article: Patient sex and use of tranexamic acid in liver transplantation
Patient sex and use of tranexamic acid in liver transplantation Open
Background Differences in medical treatment between women and men are common and involve out-of-hospital emergency care, the intensity of pain treatment, and the use of antifibrinolytic treatment in emergency trauma patients. If woman and …
View article: Intraoperative end-tidal carbon dioxide levels are not associated with recurrence-free survival after elective pancreatic cancer surgery: a retrospective cohort study
Intraoperative end-tidal carbon dioxide levels are not associated with recurrence-free survival after elective pancreatic cancer surgery: a retrospective cohort study Open
Background Intraoperative end-tidal carbon dioxide concentrations (EtCO 2 ) values are associated with recurrence-free survival after colorectal cancer surgery. However, it is unknown if similar effects can be observed after other surgical…
View article: Factors affecting adherence to recommendations on pre-operative cardiac testing
Factors affecting adherence to recommendations on pre-operative cardiac testing Open
BACKGROUND Cardiac risk evaluation prior to noncardiac surgery is fundamental to tailor peri-operative management to patient's estimated risk. Data on the degree of adherence to guidelines in patients at cardiovascular risk in Europe and f…
View article: Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial
Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial Open
The trial was registered prior to start at clinicaltrials.gov; NCT04647396.
View article: Association between self-reported functional capacity measures and postoperative myocardial injury in patients undergoing noncardiac surgeries
Association between self-reported functional capacity measures and postoperative myocardial injury in patients undergoing noncardiac surgeries Open
In elevated-risk noncardiac surgery, self-reported functional capacity measures do not significantly improve the prediction of MI; however, they add new prognostic information in centers with routine perioperative troponin monitoring.
View article: Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery
Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery Open
Lower intraoperative EtCO2 target values in CRC surgery might benefit oncological outcome and should be evaluated in confirmative studies.
View article: Intranasal Lidocaine Administration via Mucosal Atomization Device: A Simple and Successful Treatment for Postdural Puncture Headache in Obstetric Patients
Intranasal Lidocaine Administration via Mucosal Atomization Device: A Simple and Successful Treatment for Postdural Puncture Headache in Obstetric Patients Open
(1) Background: Postdural puncture headache (PDPH) remains a serious complication in obstetric patients. While the epidural blood patch represents the current gold standard in therapy, a growing number of alternative measures are thought t…
View article: NT-proBNP or Self-Reported Functional Capacity in Estimating Risk of Cardiovascular Events After Noncardiac Surgery
NT-proBNP or Self-Reported Functional Capacity in Estimating Risk of Cardiovascular Events After Noncardiac Surgery Open
Importance Nearly 16 million surgical procedures are conducted in North America yearly, and postoperative cardiovascular events are frequent. Guidelines suggest functional capacity or B-type natriuretic peptides (BNP) to guide perioperativ…
View article: Abdominal surgery induces long-lasting changes in expression and binding of CTCF with impact on Major Histocompatibility Complex II transcription in circulating human monocytes
Abdominal surgery induces long-lasting changes in expression and binding of CTCF with impact on Major Histocompatibility Complex II transcription in circulating human monocytes Open
Background Postoperative immunosuppression has been recognized as an important driver of surgery-related morbidity and mortality. It is characterized by lymphocyte depression and impaired monocyte capability to present foreign antigens to …
View article: Drainless robot-assisted minimally invasive oesophagectomy—randomized controlled trial (RESPECT)
Drainless robot-assisted minimally invasive oesophagectomy—randomized controlled trial (RESPECT) Open
Background The purpose of this randomized trial is to evaluate the early removal of postoperative drains after robot-assisted minimally invasive oesophagectomy (RAMIE). Evidence is lacking about feasibility, associated pain, recovery, and …
View article: Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial
Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial Open
Introduction Previous studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury…
View article: Characterization of Heart Rate Variability Dynamics in Heart Failure Patients Admitted to Intensive Care Unit
Characterization of Heart Rate Variability Dynamics in Heart Failure Patients Admitted to Intensive Care Unit Open
Introduction:The high mortality and difficulty of diagnosis make Heart failure (HF) a severe burden for the healthcare system, especially in intensive care units (ICU).Goal: This work proposes a method to characterize HF patients using aut…
View article: Perioperative prothrombin complex concentrate and fibrinogen administration are associated with thrombotic complications after liver transplant
Perioperative prothrombin complex concentrate and fibrinogen administration are associated with thrombotic complications after liver transplant Open
Background Use of intraoperative prothrombin complex concentrates (PCC) and fibrinogen concentrate administration has been linked to thrombotic events. However, it is unknown if its use is associated with thrombotic events after liver tran…
View article: Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19
Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19 Open
Clonal hematopoiesis of indeterminate potential (CHIP) leads to higher mortality, carries a cardiovascular risk and alters inflammation. All three aspects harbor overlaps with the clinical manifestation of COVID-19. This study aimed to ide…
View article: Target induction of heme oxygenase-1 attenuates anti-HLA I antibody induced transplant vasculopathy in an allogeneic aortic transplantation model in mice
Target induction of heme oxygenase-1 attenuates anti-HLA I antibody induced transplant vasculopathy in an allogeneic aortic transplantation model in mice Open
Introduction After solid organ transplantation every second patient develops transplant vasculopathy (TV), which still remains the major obstacle for long-term graft survival. The main risk factor for developing TV are de novo synthesized …