Jan Hau Lee
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View article: Association Between Prophylactic Anti‐Seizure Medication and Early Post‐Traumatic Seizures: An International Observational Multicenter Study
Association Between Prophylactic Anti‐Seizure Medication and Early Post‐Traumatic Seizures: An International Observational Multicenter Study Open
Evidence for the use of prophylactic anti‐seizure medication (ASM) in traumatic brain injury (TBI) in reducing the occurrence of early post‐traumatic seizure (EPTS) remains equivocal. This study aimed to analyze the prevalence of EPTS in c…
View article: Intra-cranial pressure monitoring is associated with lower in-hospital mortality but not with improved functional outcomes in pediatric traumatic brain injury: a multicenter observational study
Intra-cranial pressure monitoring is associated with lower in-hospital mortality but not with improved functional outcomes in pediatric traumatic brain injury: a multicenter observational study Open
Background Evidence that the use of invasive intracranial pressure (ICP) monitoring improves outcomes in severe traumatic brain injury (sTBI) remains equivocal. We investigated the association between invasive ICP monitoring and mortality,…
View article: Risk Factors for Mortality in Children with Hypoxemia in Resource- Constrained Settings: A Secondary Analysis of the Global PARITY Study
Risk Factors for Mortality in Children with Hypoxemia in Resource- Constrained Settings: A Secondary Analysis of the Global PARITY Study Open
Background Hypoxemia, a mortality predictor and hallmark of pediatric acute respiratory distress syndrome (PARDS), is disproportionately common in resource-constrained settings (RCS). The burden of PARDS in RCS is likely substantial consid…
View article: Sex Differences in Pediatric Sepsis Mortality: A Systematic Review and Meta-Analysis
Sex Differences in Pediatric Sepsis Mortality: A Systematic Review and Meta-Analysis Open
OBJECTIVES: Pediatric sepsis remains a leading cause of childhood mortality worldwide. Sex differences have been shown to modify risk factors, treatment, and outcome of various diseases, and adult studies revealed sex differences in pathop…
View article: Vitamin D Deficiency and Clinical Outcomes in Critically Ill Pediatric Patients: A Systematic Review and Meta-Analysis
Vitamin D Deficiency and Clinical Outcomes in Critically Ill Pediatric Patients: A Systematic Review and Meta-Analysis Open
Context Vitamin D deficiency (VDD) is common in paediatric populations, and its relationship with critical care outcomes warrants further investigation. Objective The aim is to examine the association between VDD and clinical outcomes in c…
View article: Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury
Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury Open
Importance The use of hypertonic saline (HTS) vs mannitol in the control of elevated intracranial pressure (ICP) secondary to neurotrauma is debated. Objective To compare mortality and functional outcomes of treatment with 3% HTS vs 20% ma…
View article: The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis
The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis Open
OBJECTIVES: Sepsis is a life-threatening medical emergency, with a profound healthcare burden globally. Its pathophysiology is complex, heterogeneous and temporally dynamic, making diagnosis challenging. Medical management is predicated on…
View article: Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study
Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study Open
For the French, Portuguese and Spanish translations of the abstract see Supplementary Materials section.
View article: Identifying Clinical Predictors of Raised Intracranial Pressure in Pediatric Traumatic Brain Injury—A Multinational Initiative
Identifying Clinical Predictors of Raised Intracranial Pressure in Pediatric Traumatic Brain Injury—A Multinational Initiative Open
Use of the intracranial pressure (ICP) monitor in pediatric traumatic brain injury (TBI) remains variable. Clinical prediction models of raised ICP have been reported in adult TBI but have not been validated in pediatric TBI. We aimed to i…
View article: An Audit of a Modified Pediatric Early Warning Scoring System in a Tertiary Pediatric Hospital
An Audit of a Modified Pediatric Early Warning Scoring System in a Tertiary Pediatric Hospital Open
OBJECTIVE Pediatric early warning systems identify patients at risk for deterioration. We aimed to determine if a locally adapted pediatric early warning system [KK hospital early warning score (KEWS)] can distinguish patients who require …
View article: FedDSS: A data-similarity approach for client selection in horizontal federated learning
FedDSS: A data-similarity approach for client selection in horizontal federated learning Open
We demonstrated that FedDSS contributes to improved learning in FL by achieving faster convergence, reaching the desired TPR with fewer communication rounds, and potentially enhancing sepsis prediction (TPR) over FedAvg.
View article: Pharmacoepidemiology of combination pulmonary vasodilator therapy in critically ill infants
Pharmacoepidemiology of combination pulmonary vasodilator therapy in critically ill infants Open
Background: New drugs to target different pathways in pulmonary hypertension has resulted in increased combination therapy, but details of this use in infants are not well described. In this large multicenter database study, we describe th…
View article: Med-MGF: multi-level graph-based framework for handling medical data imbalance and representation
Med-MGF: multi-level graph-based framework for handling medical data imbalance and representation Open
When compared to all baseline models, MedMGF achieved the highest SEN and AUC results, demonstrating the potential for several healthcare applications.
View article: Sex differences in pediatric sepsis—a systematic review protocol
Sex differences in pediatric sepsis—a systematic review protocol Open
PROSPERO CRD42022315753.
View article: Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation
Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation Open
Importance The effectiveness of daily sedation interruption (DSI, defined as temporary interruption of sedation) has yet to be demonstrated in critically ill pediatric patients. Objective To compare the clinical outcomes of DSI vs continuo…
View article: Physical, Cognitive, Emotional, and Social Health Outcomes of Parents in the First Six Months after Childhood Critical Illness: A Prospective Single Centre Study
Physical, Cognitive, Emotional, and Social Health Outcomes of Parents in the First Six Months after Childhood Critical Illness: A Prospective Single Centre Study Open
Childhood critical illness can have long-term effects on families, but the extent and trajectory of recovery for parents are unknown. Using prospective longitudinal design, we describe the health outcomes of parents and their trajectory si…
View article: Use of Speckle-Tracking Echocardiography in Septic Cardiomyopathy in Critically Ill Children: A Narrative Review
Use of Speckle-Tracking Echocardiography in Septic Cardiomyopathy in Critically Ill Children: A Narrative Review Open
OBJECTIVES: In critically ill children with severe sepsis, septic cardiomyopathy (SCM) denotes the subset of patients who have myocardial dysfunction with poor response to fluid and inotropic support, and higher mortality risk. The objecti…
View article: Parental emotional, social and transitional health in the first 6 months after childhood critical illness: A longitudinal qualitative study
Parental emotional, social and transitional health in the first 6 months after childhood critical illness: A longitudinal qualitative study Open
Aim To explore the experiences and support needs of parents in the first 6 months after paediatric critical care. Design Longitudinal qualitative design. Methods Sequential semi‐structured qualitative interviews were conducted with a sampl…
View article: A two-phased study on the use of remote photoplethysmography (rPPG) in paediatric care
A two-phased study on the use of remote photoplethysmography (rPPG) in paediatric care Open
Our study showed that rPPG is acceptable and feasible for neonates and children aged 5 to 16 years, and HR values in older children aged 12 to 16 years correlated well with the current standard. The rPPG algorithms need to be further refin…
View article: The Epidemiology of Critical Respiratory Diseases in Ex-premature Infants in Vietnam: A Prospective Single-Center Study
The Epidemiology of Critical Respiratory Diseases in Ex-premature Infants in Vietnam: A Prospective Single-Center Study Open
Introduction This study aimed to describe the epidemiology and etiologies of critical respiratory diseases of ex-premature infants (EPIs) admitted to pediatric intensive care unit (PICU). In addition, we described the outcomes and resource…
View article: Volume Targeting During High-Frequency Oscillatory Ventilation: What Should Clinicians Know
Volume Targeting During High-Frequency Oscillatory Ventilation: What Should Clinicians Know Open
Volume targeting in high-frequency oscillatory ventilation (HFOV) reduces CO2 variability and allows effective ventilation with very small tidal volumes (VT).1 Using volume targeting during HFOV requires the clinician to think differently …
View article: Ethnic differences in parental experiences during the first six months after PICU discharge in Singapore: a qualitative study
Ethnic differences in parental experiences during the first six months after PICU discharge in Singapore: a qualitative study Open
Introduction Literature on parental experiences after childhood critical illness has limited representation from diverse ethnic backgrounds. Parents from global ethnic majority groups have reported worst psychological outcomes and required…
View article: A research definition and framework for acute paediatric critical illness across resource-variable settings: a modified Delphi consensus
A research definition and framework for acute paediatric critical illness across resource-variable settings: a modified Delphi consensus Open
The true global burden of paediatric critical illness remains unknown. Studies on children with life-threatening conditions are hindered by the absence of a common definition for acute paediatric critical illness (DEFCRIT) that outlines co…
View article: Trimethoprim-sulfamethoxazole-induced lung injury: a case report
Trimethoprim-sulfamethoxazole-induced lung injury: a case report Open
Diagnosis of DLI can be challenging. The early identification of DLI and discontinuation of culprit drug is essential in its management. Further understanding of the underlying pathophysiology and risk factors for TMP-SMX-associated DLI is…
View article: The use of probabilistic graphical models in pediatric sepsis: a feasibility and scoping review
The use of probabilistic graphical models in pediatric sepsis: a feasibility and scoping review Open
Current studies suggest that the performance of probabilistic graphic models is relatively inferior to other ML methods. However, its explainability and transparency advantages make it a potentially viable method for several pediatric seps…