Jan Leppert
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View article: Prediction of thermal modulated comprehensive two-dimensional gas chromatographic separation using a modular, graph-based simulation platform
Prediction of thermal modulated comprehensive two-dimensional gas chromatographic separation using a modular, graph-based simulation platform Open
Comprehensive two-dimensional gas chromatography (GC×GC) offers exceptional separation performance, but method development remains time-consuming and sensitive to numerous system parameters. In this study, we present a modular simulation f…
View article: Insights into Application of Metaverse and Virtual Platforms with Gas Chromatography: Communication, Concept Understanding, Instrumental Training, Optimization Skill Development, and Database Sharing
Insights into Application of Metaverse and Virtual Platforms with Gas Chromatography: Communication, Concept Understanding, Instrumental Training, Optimization Skill Development, and Database Sharing Open
Scientific collaboration traditionally relies on activities such as workshops, training programs, services, conferences, and personal meetings. In recent years, commercial-academic partnerships and global events such as pandemics have acce…
View article: Sex-related Survival Differences in Patients With Glioblastoma – Results From a Retrospective Analysis
Sex-related Survival Differences in Patients With Glioblastoma – Results From a Retrospective Analysis Open
Sex seems to impact survival in patients suffering from glioblastoma, although underlying mechanisms are not yet completely understood. Treatment intensity (complete resection and the maximum possible number of TMZ cycles) had a significan…
View article: High-efficiency base editing in the retina in primates and human tissues
High-efficiency base editing in the retina in primates and human tissues Open
View article: Salivary Gland Volume Predicts Malnutrition in Irradiated Head and Neck Cancer Patients: A Prospective Analysis
Salivary Gland Volume Predicts Malnutrition in Irradiated Head and Neck Cancer Patients: A Prospective Analysis Open
BACKGROUND/AIM: Xerostomia following (chemo-) radiotherapy (CRT) is common in head and neck (HNC) patients. This prospective study focused on investigating the link between salivary gland function and the onset of malnutrition in HNC patie…
View article: The Predictive Value of Different Glasgow Prognostic Scores and the LabBM Score for Patients With Recurrent Glioblastoma
The Predictive Value of Different Glasgow Prognostic Scores and the LabBM Score for Patients With Recurrent Glioblastoma Open
Lower oGPS, mGPS, and LabBM scores were significantly associated with improved OS on univariate analyses. These instruments may be helpful when designing personalized treatment regimens for patients with recurrent glioblastoma.
View article: Generalized flow calculation of the gas flow in a network of capillaries used in gas chromatography
Generalized flow calculation of the gas flow in a network of capillaries used in gas chromatography Open
A general method for the calculation of the flow and pressure of a gas in a network of cylindrical capillaries is presented. This method is used specifically for gas chromatographic systems in this work. With this approach, it is possible …
View article: REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage Open
OBJECTIVE Ischemic complications account for significant patient morbidity following aneurysmal subarachnoid hemorrhage (aSAH). The Prevention and Treatment of Vasospasm with Clazosentan (REACT) study was designed to assess the safety and …
View article: Prognostic Role of Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratios in Patients Irradiated for Glioblastoma Multiforme
Prognostic Role of Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratios in Patients Irradiated for Glioblastoma Multiforme Open
Background/Aim: Previous studies suggested pre-operative platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to be predictive factors in patients with glioblastoma multiforme (GBM). This study investigated the progn…
View article: Prognostic Factors for Progression-free Survival and Overall Survival After Recurrence of Glioblastoma
Prognostic Factors for Progression-free Survival and Overall Survival After Recurrence of Glioblastoma Open
Our study identified high Karnofsky Performance Status (KPS 90-100), maximum cumulative diameter of recurrent glioblastoma lesions ≤40 mm, and systemic therapy for recurrent glioblastoma as independent predictors of overall survival (OS) a…
View article: Relation between characteristic temperature and elution temperature in temperature programmed gas chromatography – Part II: Influence of column properties
Relation between characteristic temperature and elution temperature in temperature programmed gas chromatography – Part II: Influence of column properties Open
The method development process in gas chromatography can be accelerated by suitable computer simulation tools using knowledge about the solute-column interactions described by thermodynamic retention parameters. Since retention parameters …
View article: Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial
Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial Open
View article: Molecular signature of stem-like glioma cells (SLGCs) from human glioblastoma and gliosarcoma
Molecular signature of stem-like glioma cells (SLGCs) from human glioblastoma and gliosarcoma Open
Glioblastoma multiforme (GBM) and the GBM variant gliosarcoma (GS) are among the tumors with the highest morbidity and mortality, providing only palliation. Stem-like glioma cells (SLGCs) are involved in tumor initiation, progression, ther…
View article: Simulation of gas chromatographic separations and estimation of distribution-centric retention parameters using linear solvation energy relationships
Simulation of gas chromatographic separations and estimation of distribution-centric retention parameters using linear solvation energy relationships Open
For method development in gas chromatography, suitable computer simulations can be very helpful during the optimization process. For such computer simulations retention parameters are needed, that describe the interaction of the analytes w…
View article: Relation between Characteristic Temperature and Elution Temperature in Temperature Programmed Gc – Part Ii: Influence of Column Properties
Relation between Characteristic Temperature and Elution Temperature in Temperature Programmed Gc – Part Ii: Influence of Column Properties Open
View article: Evaluation of Five Prognostic Scores in Patients Receiving Chemoradiation for Primary Glioblastoma Multiforme
Evaluation of Five Prognostic Scores in Patients Receiving Chemoradiation for Primary Glioblastoma Multiforme Open
The oGPS was an independent predictor of OS in patients receiving chemoradiation for GBM and can help personalizing the treatment for these patients. The LabBM score may be useful for predicting PFS.
View article: Can Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) Help Predict Outcomes of Patients With Recurrent Glioblastoma?
Can Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) Help Predict Outcomes of Patients With Recurrent Glioblastoma? Open
In addition to other characteristics, PLR at the time of recurrence was identified as an independent predictor of OS in patients with recurrent glioblastoma. PLR may be useful when designing personalized treatment approaches or clinical tr…
View article: Identification of Patients With Glioblastoma Who May Benefit from Hypofractionated Radiotherapy
Identification of Patients With Glioblastoma Who May Benefit from Hypofractionated Radiotherapy Open
A new survival score with higher accuracy was developed for patients with glioblastoma. Our model can be utilized to individualize RT dose-fractionation recommendations for glioblastoma.
View article: Retention Database for Prediction, Simulation, and Optimization of GC Separations
Retention Database for Prediction, Simulation, and Optimization of GC Separations Open
This work presents an open source database with suitable retention parameters for prediction and simulation of GC separations and gives a short introduction to three common retention models. Useful computer simulations play an important ro…
View article: Pre-treatment Emotional Distress in Patients Irradiated for Malignant Glioma
Pre-treatment Emotional Distress in Patients Irradiated for Malignant Glioma Open
Three-fourths of glioma patients had pre-radiotherapy emotional distress. Psychological support should be offered very soon, particularly for high-risk patients.
View article: Dependence between Characteristic Temperature and Elution Temperature in Temperature Programmed Gas Chromatography – Part I: Influence of Initial Temperature and Heating Rate
Dependence between Characteristic Temperature and Elution Temperature in Temperature Programmed Gas Chromatography – Part I: Influence of Initial Temperature and Heating Rate Open
View article: Simulation of Gas Chromatographic Separations and Estimation of Distribution-Centric Retention Parameters Using Linear Solvation Energy Relationships (Lser)
Simulation of Gas Chromatographic Separations and Estimation of Distribution-Centric Retention Parameters Using Linear Solvation Energy Relationships (Lser) Open
View article: Estimation of Retention Parameters from Temperature Programmed Gc
Estimation of Retention Parameters from Temperature Programmed Gc Open
View article: GasChromatographySimulator.jl
GasChromatographySimulator.jl Open
Gas chromatography (GC) is a technique used in analytical chemistry to separate a mixture of vaporizable substances by injecting the mixture into a gas stream (mobile phase), which passes along a tube, called column, of length and diameter…
View article: Paraneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review
Paraneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review Open
Background Recently, antibodies against the alpha isoform of the glial-fibrillary-acidic-protein (GFAPα) were identified in a small series of patients with encephalomyelitis. Coexisting autoantibodies (NMDA receptor, GAD65 antibodies) have…
View article: A New Survival Score for Patients Receiving Radiotherapy for Newly Diagnosed Glioblastoma Multiforme
A New Survival Score for Patients Receiving Radiotherapy for Newly Diagnosed Glioblastoma Multiforme Open
A new survival score was created for patients requiring radiotherapy for GBM that can improve treatment personalization.
View article: Re-Irradiation for Recurrent Glioblastoma Multiforme
Re-Irradiation for Recurrent Glioblastoma Multiforme Open
Predictors of survival after re-irradiation for recurrent GBM were identified that can help when designing personalized treatments. Use of irradiation with EQD2 ≥30 Gy appeared superior to lower doses.
View article: Non-compliant and compliant balloons for endovascular rescue therapy of cerebral vasospasm after spontaneous subarachnoid haemorrhage: experiences of a single-centre institution with radiological follow-up of the treated vessel segments
Non-compliant and compliant balloons for endovascular rescue therapy of cerebral vasospasm after spontaneous subarachnoid haemorrhage: experiences of a single-centre institution with radiological follow-up of the treated vessel segments Open
Background For endovascular rescue therapy (ERT) of cerebral vasospasm (CVS) due to spontaneous subarachnoid haemorrhage (sSAH), non-compliant (NCB) and compliant (CB) balloons are used with both balloon types bearing the risk of vessel in…