Jan Meiners
YOU?
Author Swipe
View article: A Comprehensive Analysis of Tn and STn Antigen Expression in Esophageal Adenocarcinoma
A Comprehensive Analysis of Tn and STn Antigen Expression in Esophageal Adenocarcinoma Open
Differential glycosylation, marked by the presence of truncated O-glycans, is a distinctive feature of epithelial-derived cancers. However, there is a notable gap in research regarding the expression of Tn and STn antigens in esophageal ad…
View article: PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power
PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power Open
The current risk stratification in prostate cancer (PCa) is frequently insufficient to adequately predict disease development and outcome. One hallmark of cancer is telomere maintenance. For telomere maintenance, PCa cells exclusively empl…
View article: Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours
Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours Open
Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissu…
View article: Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer
Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer Open
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. There is an urgent need to identify prognostic markers for patients undergoing curative resection of CRC. The detection of circulating tumor cells in periphera…
View article: Prognostic Value of Preoperative Circulating Tumor Cell Counts in Patients with UICC-Stage I-IV Colorectal Cancer
Prognostic Value of Preoperative Circulating Tumor Cell Counts in Patients with UICC-Stage I-IV Colorectal Cancer Open
The detection of CTCs in peripheral blood is one of the most promising approaches to identify disseminated disease in colorectal cancer (CRC). This study aims to evaluate the prognostic relevance of preoperative CTCs using the Cellsearch® …
View article: Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer
Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer Open
Protein phosphatase 1 nuclear-targeting subunit (PNUTS) is ubiquitously expressed and associates with PTEN and protein phosphatase 1 (PP1) to control its activity. The role of PNUTS overexpression has hardly been studied in cancer. In this…
View article: Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in <i>TMPRSS2:ERG</i> fusion‐positive prostate cancers
Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in <i>TMPRSS2:ERG</i> fusion‐positive prostate cancers Open
Altered expression of the carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) has been linked to adverse tumor features in various cancer types. To better understand the role of CEACAM1 in prostate cancer, we analyzed a tis…
View article: Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion
Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion Open
Loss of the putative tumor suppressor BAP1 is a candidate biomarker for adverse prognosis in many cancer types, but conversely for improved survival in others. Studies on the expression and prognostic role of BAP1 in prostate cancer are cu…
View article: Random forest-based modelling to detect biomarkers for prostate cancer progression
Random forest-based modelling to detect biomarkers for prostate cancer progression Open
Background The clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not progress to aggressive stages, may be associated with sev…
View article: Upregulation of SPDEF is associated with poor prognosis in prostate cancer
Upregulation of SPDEF is associated with poor prognosis in prostate cancer Open
SAM pointed domain-containing Ets transcription factor (SPDEF), a member of the ETS transcription factor family, has been associated with prostate cancer development; however, its role in tumour development and progression is controversial…
View article: Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer
Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer Open
Dysregulation of lipid metabolism is common in cancer. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been implicated with various cancer types. Here we analyzed by immunohistochemistry its expression in 2,197 breast cancers. LPCAT…
View article: Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy Open
ELAC2 is a ubiquitously expressed enzyme potentially involved in tRNA processing and cell signaling pathways. Mutations of the ELAC2 gene have been found to confer increased prostate cancer susceptibility in families. ELAC2 protein express…
View article: Random forest-based modelling to detect biomarkers for prostate cancer progression
Random forest-based modelling to detect biomarkers for prostate cancer progression Open
The clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy and robust prognostic markers for treatment decisions. We present a random forest-based classification model to predict aggres…
View article: MOESM1 of Random forest-based modelling to detect biomarkers for prostate cancer progression
MOESM1 of Random forest-based modelling to detect biomarkers for prostate cancer progression Open
Additional file 1: Table S1. Clinical information and cell type composition of discovery cohort samples.
View article: MOESM2 of Random forest-based modelling to detect biomarkers for prostate cancer progression
MOESM2 of Random forest-based modelling to detect biomarkers for prostate cancer progression Open
Additional file 2: Table S2. Full list of CpG sites contributing to the model.