Mohammed M. Jan
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View article: Predisposition of an Intronic Duplication in CHEK2 Gene in the Cases of Breast Cancer from Balochistan
Predisposition of an Intronic Duplication in CHEK2 Gene in the Cases of Breast Cancer from Balochistan Open
Our results suggest that the intronic variant identified in breast cancer cases as well as reported previously may act as a cancer marker and causing a splice site disruption or altering the posttranscriptional modification of mRNA encoded…
View article: Short-term effectiveness and side effects of ketogenic diet for drug-resistant epilepsy in children with genetic epilepsy syndromes
Short-term effectiveness and side effects of ketogenic diet for drug-resistant epilepsy in children with genetic epilepsy syndromes Open
Background Drug-resistant epilepsy (DRE) impacts a significant portion, one-third, of individuals diagnosed with epilepsy. In such cases, exploring non-pharmacological interventions are crucial, with the ketogenic diet (KD) standing out as…
View article: Insight into Genetic Mutations of SZT2: Is It a Syndrome?
Insight into Genetic Mutations of SZT2: Is It a Syndrome? Open
Background: The seizure threshold 2 (SZT2) gene encodes a protein of unknown function, which is widely expressed, confers a low seizure threshold, and enhances epileptogenesis. It also comprises the KICSTOR protein complex, which inhibits …
View article: Treatment of drop attacks: Anti-seizure drug choices of pediatric neurologists in Saudi Arabia
Treatment of drop attacks: Anti-seizure drug choices of pediatric neurologists in Saudi Arabia Open
The majority of pediatric neurologists in Saudi Arabia chose valproic acid and/or levetiracetam as the first line of treatment for EDA. These results highlight the need for an evidence-based clinical guidelines to treat EDA.
View article: The Impact of Model Courts on the Criminal Justice System of Khyber Pakhtunkhwa: A Case Study Based on Statistical Evaluation
The Impact of Model Courts on the Criminal Justice System of Khyber Pakhtunkhwa: A Case Study Based on Statistical Evaluation Open
The provision of inexpensive and expeditious justice is one of the constitutional responsibilities of the state, which is fulfilled through the instrument of the judiciary. In pursuance of the Expeditious Justice Initiative, the government…
View article: DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children [Corrigendum]
DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children [Corrigendum] Open
[This corrects the article DOI: 10.2147/PGPM.S346187.].
View article: Peer Review #3 of "Hypoxia-induced factor and its role in liver fibrosis (v0.2)"
Peer Review #3 of "Hypoxia-induced factor and its role in liver fibrosis (v0.2)" Open
Liver fibrosis develops due to severe liver damage and is considered a major clinical concern throughout the world.Many factors are crucial for liver fibrosis progression.While advancements have been made to understand this disease, no eff…
View article: Peer Review #3 of "Hypoxia-induced factor and its role in liver fibrosis (v0.1)"
Peer Review #3 of "Hypoxia-induced factor and its role in liver fibrosis (v0.1)" Open
Liver fibrosis develops due to severe liver damage and is considered a major clinical concern throughout the world.Many factors are crucial for liver fibrosis progression.While advancements have been made to understand this disease, no eff…
View article: SEXUAL HARASSMENT IN THE WORKPLACE: A PROPORTIONAL EXAMINATION OF RELEVANT LEGISLATION, WITH COMPARISONS TO TWO MAJOR ASIAN COUNTRIES: INDIA AND PAKISTAN
SEXUAL HARASSMENT IN THE WORKPLACE: A PROPORTIONAL EXAMINATION OF RELEVANT LEGISLATION, WITH COMPARISONS TO TWO MAJOR ASIAN COUNTRIES: INDIA AND PAKISTAN Open
Pakistan and India consider sexual harassment a negation of basic rights. Both countries have ratified the CEDAW and their relevant laws on sexual harassment are aligned with the 19th ILO recommendation. Both Pakistani and Indian laws rely…
View article: Multiple Recurrent Copy Number Variations (CNVs) in Chromosome 22 Including 22q11.2 Associated with Autism Spectrum Disorder
Multiple Recurrent Copy Number Variations (CNVs) in Chromosome 22 Including 22q11.2 Associated with Autism Spectrum Disorder Open
CNV deletion and the duplication of the TBX1 gene could be related to ASD; therefore, this gene needs more analysis in terms of expression levels.
View article: DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children
DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children Open
Khloud Algothmi,1 Amal Alqurashi,1 Aisha Alrofaidi,1 Mona Alharbi,1 Reem Farsi,1 Najla Alburae,1 Magdah Ganash,1 Sheren Azhari,1 Fatemah Basingab,1 Asma Almuhammadi,1 Amany Alqosaibi,2 Heba Alkhatabi,3,4 Aisha Elaimi,3,4 Mohammed Jan,5 Hes…
View article: Combating the Harassment of Women at Workplace: An Analysis of Legislation in Pakistan
Combating the Harassment of Women at Workplace: An Analysis of Legislation in Pakistan Open
The 3 P's, i.e., the security, promotion, and provision of fundamental rights to its people, are widely regarded as the hallmarks of an effective legal system. These 3Ps are enforced in both formal and informal legal structures. Gender-bas…
View article: The Correlation between Gene Expression and DNA Methylation Levels of RAS p21 Protein Activator 3 (RASA3) Gene in Saudi Autistic Children
The Correlation between Gene Expression and DNA Methylation Levels of RAS p21 Protein Activator 3 (RASA3) Gene in Saudi Autistic Children Open
The potential role of DNA methylation pattern in autism has been provided by revealing the differences in methylation level of multiple genes which are significantly associated with their expression and implicated in ASD pathogenesis. RASA…
View article: Association Between RAS-Like Proto-Oncogene B (RALB) Gene Expression and Methylation Levels in Saudi Autistic Children
Association Between RAS-Like Proto-Oncogene B (RALB) Gene Expression and Methylation Levels in Saudi Autistic Children Open
RAS like proto-oncogene B (RALB) gene is located in human chromosome 2 and encodes a GTP-binding protein that belongs to RAS subfamily of the small GTPase superfamily. Recently, RAS signaling pathway has been studied as likely related to A…
View article: Next generation sequencing reveals novel homozygous frameshift in PUS7 and splice acceptor variants in AASS gene leading to intellectual disability, developmental delay, dysmorphic feature and microcephaly
Next generation sequencing reveals novel homozygous frameshift in PUS7 and splice acceptor variants in AASS gene leading to intellectual disability, developmental delay, dysmorphic feature and microcephaly Open
View article: Whole exome sequencing reveals a homozygous nonsense mutation in HEXA gene leading to Tay-Sachs disease in Saudi Family
Whole exome sequencing reveals a homozygous nonsense mutation in HEXA gene leading to Tay-Sachs disease in Saudi Family Open
Objective: To study the causative variants in affected member of a Saudi family with Tay-Sachs disorder. This disorder includes paralysis, decreasing in attentiveness, seizures, blindness, motor deterioration progresses rapidly leading to …
View article: Immunoglobulin G and Total Protein Concentration in Blood and Colostrum of Different Cattle Breeds and its Passive Transfer to Neonatal Calves
Immunoglobulin G and Total Protein Concentration in Blood and Colostrum of Different Cattle Breeds and its Passive Transfer to Neonatal Calves Open
The aim of this study was to determine the effect of cattle breed type on (a) cow serum IgG and serum total protein concentration (b) colostrum immunoglobulin level and (c) their respective calves' serum immunoglobulin and serum total prot…
View article: Survey of non-resuscitation fluids administered during septic shock: a multicenter prospective observational study
Survey of non-resuscitation fluids administered during septic shock: a multicenter prospective observational study Open
Background The indication, composition and timing of administration of non-resuscitation fluid in septic shock have so far received little attention and accordingly the potential to reduce this source of fluid is unknown. The objective of …
View article: Current Management of Duchenne Muscular Dystrophy in the Middle East: Expert Report
Current Management of Duchenne Muscular Dystrophy in the Middle East: Expert Report Open
Aim: Duchenne muscular dystrophy (DMD) is a severe and rare X-linked neuromuscular childhood disorder that results in functional decline, loss of ambulation and early death due to cardiac or respiratory failure. The objective of thi…
View article: The Impact of Pediatric Epilepsy on Children and Families: A Multicenter Cross-Sectional Study
The Impact of Pediatric Epilepsy on Children and Families: A Multicenter Cross-Sectional Study Open
Background and Objectives: Epilepsy is considered one of the most prevalent causes of morbidity in children. The aim of this study is to determine how epilepsy impacts the lives of children with epilepsy and their families. Methods: A tran…
View article: Parental perceptions of dental health and need for treatment in children with epilepsy: a multicenter cross-sectional study
Parental perceptions of dental health and need for treatment in children with epilepsy: a multicenter cross-sectional study Open
In most children with epilepsy, perceived dental status was bad and there was a high expressed need for dental care. Interventions to improve the dental health of children with epilepsy should focus on those with cerebral palsy and motor d…
View article: Treatment of infantile spasms in Saudi Arabia
Treatment of infantile spasms in Saudi Arabia Open
Many pediatric neurologists in KSA are not following the published IS management guidelines. Using ACTH as first line correlated with their training, practice location, and years of experience. Lack of drug availability and side effect pro…
View article: Use of Electronic Entertainment and Communication Devices Among a Saudi Pediatric Population: Cross-Sectional Study
Use of Electronic Entertainment and Communication Devices Among a Saudi Pediatric Population: Cross-Sectional Study Open
Parental awareness is necessary to counteract the harmful effects of using electronic devices for a prolonged period. Parents require help to cope with this problem effectively.
View article: Transcranial Magnetic Stimulation and Epilepsy
Transcranial Magnetic Stimulation and Epilepsy Open
View article: Use of electronic entertainment and communication devices amongst a Saudi pediatric population: A cross-sectional study (Preprint)
Use of electronic entertainment and communication devices amongst a Saudi pediatric population: A cross-sectional study (Preprint) Open
View article: Use of Electronic Entertainment and Communication Devices Among a Saudi Pediatric Population: Cross-Sectional Study (Preprint)
Use of Electronic Entertainment and Communication Devices Among a Saudi Pediatric Population: Cross-Sectional Study (Preprint) Open
BACKGROUND Excessive use of various electronic entertainment and communication devices, particularly among children, has been associated with increased behavioral problems. Despite children’s escalating use of these devices, parents’ awar…
View article: Publications pattern of clinical epilepsy research in Saudi Arabia
Publications pattern of clinical epilepsy research in Saudi Arabia Open
Pattern of publications in clinical epilepsy researches revealed a slow growth rate in the frequency and a lower significance in the quality throughout the past 26 years. Active institutional and national promotion of clinical research is …
View article: Public awareness of autism spectrum disorder
Public awareness of autism spectrum disorder Open
The public awareness of ASD needs improvement. Areas for targeted education were identified to help improve the quality of life of autistic children and their families.
View article: Management of convulsive status epilepticus in children: an adapted clinical practice guideline for pediatricians in Saudi Arabia
Management of convulsive status epilepticus in children: an adapted clinical practice guideline for pediatricians in Saudi Arabia Open
Objective: To increase the use of evidence-based approaches in the diagnosis, investigations and treatment of Convulsive Status Epilepticus (CSE) in children in relevant care settings. Method: A Clinical Practice Guideline (CPG) adaptation…
View article: ADHD Awareness Among Medical Students
ADHD Awareness Among Medical Students Open
Background: Early recognition of attention deficit hyperactivity disorder (ADHD) is needed to prevent its psychosocial and educational consequences.We aimed to study ADHD awareness among medical students and identify correlating and contri…