Jan Münch
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View article: Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases
Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases Open
Background The C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are pivotal in tissue regeneration and inflammation, yet their role in osteoarthritis (OA) remains ambiguous. However, it is assumed that the CXCL12/CXCR4 axis likely …
View article: An endogenous human peptide derived from α1-antitrypsin as a novel pharmacological inhibitor of Bordetella pertussis toxin
An endogenous human peptide derived from α1-antitrypsin as a novel pharmacological inhibitor of Bordetella pertussis toxin Open
Pertussis, also known as whooping cough, is a highly infectious respiratory disease caused by the bacterium Bordetella pertussis . The bacterial virulence factor, pertussis toxin (PT), is associated with the manifestation of the characteri…
View article: Peptide-based antagonists for targeting CXCR4 in ibrutinib resistant chronic lymphocytic leukemia
Peptide-based antagonists for targeting CXCR4 in ibrutinib resistant chronic lymphocytic leukemia Open
Bruton tyrosine kinase inhibitors (BTKi) have revolutionized chronic lymphocytic leukemia (CLL) treatment. However, resistance develops, making it important to identify alternative treatment targets. CXCR4, a G protein coupled receptor, re…
View article: RapTB: a lung-derived hemoglobin fragment with activity against Mycobacterium tuberculosis
RapTB: a lung-derived hemoglobin fragment with activity against Mycobacterium tuberculosis Open
Tuberculosis (TB) remains difficult to treat due to the need for prolonged multidrug therapy and the global rise of drug-resistant Mycobacterium tuberculosis ( Mtb ) strains. Endogenous antimicrobial peptides (AMPs) have emerged as promisi…
View article: <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 convalescent plasma for the controlled clinical trial “ <scp>COVIC</scp> ‐19”: Experience from collection of very high‐titer plasma from superimmunized individuals
<span>SARS</span> ‐ <span>CoV</span> ‐2 convalescent plasma for the controlled clinical trial “ <span>COVIC</span> ‐19”: Experience from collection of very high‐titer plasma from superimmunized individuals Open
Background COVID‐19 convalescent plasma (CCP) is a treatment option for COVID‐19. Understanding of donor and product characteristics is important for optimization of CCP therapy. We report the experience of collection of very high‐titer CC…
View article: Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases
Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases Open
Background The C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are pivotal in tissue regeneration and inflammation, yet their role in osteoarthritis (OA) remains ambiguous. However, it is assumed that the CXCL12/CXCR4 axis likely …
View article: From data silos to insights: the PRINCE multi-agent knowledge engine for preclinical drug development
From data silos to insights: the PRINCE multi-agent knowledge engine for preclinical drug development Open
The pharmaceutical industry faces pressure to improve the drug development process while reducing costs in an evolving regulatory landscape. This paper presents the Preclinical Information Center (PRINCE), a cloud-hosted data integration p…
View article: Interactions of Peptide Amphiphiles With Viruses and Cells Are Enabled by Amorphous Nanostructures
Interactions of Peptide Amphiphiles With Viruses and Cells Are Enabled by Amorphous Nanostructures Open
Peptide amphiphiles can form fibrillar and amorphous structures. While fibrillar assemblies have previously been shown to enhance viral infectivity or retroviral transduction for gene delivery, we now elucidate the mechanism behind amorpho…
View article: Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses
Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses Open
Respiratory viruses, such as SARS‐CoV‐2 and influenza, exploit host proteases like TMPRSS2 for entry, making TMPRSS2 a prime antiviral target. Here, the identification and characterization of Trypstatin, a 61‐amino acid Kunitz‐type proteas…
View article: Peptidnanofibrillen als Transduktionsverstärker für die Gentherapie
Peptidnanofibrillen als Transduktionsverstärker für die Gentherapie Open
Low transduction efficiencies limit the effectiveness of retroviral vectors in gene therapy. Self-assembling nanostructures, such as peptide nanofibrils (PNF) and peptide amphiphiles (PA), are powerful transduction enhancers that address t…
View article: Mimicking immune complexes for efficient antibody responses
Mimicking immune complexes for efficient antibody responses Open
Efficient antibody responses are crucial for combating infectious diseases and vaccination remains a cornerstone of this effort. This study introduces a novel approach for enhancing immune responses in wild-type mice by utilizing pre-forme…
View article: Novel peptide targeting CXCR4 disrupt tumor-stroma crosstalk to eliminate migrating cancer stem cells
Novel peptide targeting CXCR4 disrupt tumor-stroma crosstalk to eliminate migrating cancer stem cells Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and metastatic malignancies worldwide. Migrating cancer stem cells (miCSCs) marked by CD133+CXCR4+ expression drives metastasis but lacks effective drug targets. Here, w…
View article: Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19: an international, randomised, open-label trial
Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19: an international, randomised, open-label trial Open
Support-e project (European Union's Horizon 2020 Programme), German Federal Ministry of Education and Research, ZonMw, the Netherlands Organisation for Health Research and Development.
View article: CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma
CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma Open
CD19 and CXCR4 are pivotal regulators of B-cell activation and migration, respectively. Specifically, CXCR4 signaling critically influences the dissemination of various malignant B cells through constitutive activation and aberrant express…
View article: Versatile Features of an Antibody Mimetic Peptide and Its Variants
Versatile Features of an Antibody Mimetic Peptide and Its Variants Open
Antibody mimetic peptides have evolved as versatile tools for biomedical applications, based on their ability to interfere with protein–protein interactions. We had previously designed a functional mimic of the broadly neutralizing HIV‐1 a…
View article: SEVI Fibrils are Induced by Bacterial Surface Molecules and Exert Antimicrobial Activity Against ESKAPE Pathogens
SEVI Fibrils are Induced by Bacterial Surface Molecules and Exert Antimicrobial Activity Against ESKAPE Pathogens Open
The semen-derived enhancer of viral infection (SEVI) is an amyloid fibril formed by the self-assembly of the PAP248-286 peptide, a cleavage product of prostatic acid phosphatase, which is naturally present in human seminal plasma. SEVI is …
View article: α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia
α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia Open
HIV-associated neurocognitive disorders (HAND) and viral reservoirs in the brain remain a significant challenge. Despite their importance, the mechanisms allowing HIV-1 entry and replication in the central nervous system (CNS) are poorly u…
View article: Transduction enhancing EF-C peptide nanofibrils are endocytosed by macropinocytosis and subsequently degraded
Transduction enhancing EF-C peptide nanofibrils are endocytosed by macropinocytosis and subsequently degraded Open
Retroviral gene transfer is the preferred method for stable, long-term integration of genetic material into cellular genomes, commonly used to generate chimeric antigen receptor (CAR)-T cells designed to target tumor antigens. However, the…
View article: CXCR4 Inhibition Enhances Efficacy of CD19 Monoclonal Antibody Mediated Extermination of B Cell Lymphoma
CXCR4 Inhibition Enhances Efficacy of CD19 Monoclonal Antibody Mediated Extermination of B Cell Lymphoma Open
CD19 and CXCR4 are pivotal regulators of B cell activation and migration, respectively. Specifically, CXCR4 signaling critically influences the dissemination of various malignant B cells through constitutive activation and aberrant express…
View article: Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity
Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity Open
Host-directed antivirals (HDAs) represent an attractive treatment option and a strategy for pandemic preparedness, especially due to their potential broad-spectrum antiviral activity and high barrier to resistance development. Particularly…
View article: Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stability
Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stability Open
Dysregulation of the CXCL12/CXCR4 axis is implicated in autoimmune, inflammatory, and oncogenic diseases, positioning CXCR4 as a pivotal therapeutic target. We evaluated optimized variants of the specific endogenous CXCR4 antagonist, EPI-X…
View article: An Optimized Peptide Antagonist of CXCR4 Limits Survival of BCR–ABL1-Transformed Cells in Philadelphia-Chromosome-Positive B-Cell Acute Lymphoblastic Leukemia
An Optimized Peptide Antagonist of CXCR4 Limits Survival of BCR–ABL1-Transformed Cells in Philadelphia-Chromosome-Positive B-Cell Acute Lymphoblastic Leukemia Open
Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is characterized by reciprocal chromosomal translocation between chromosome 9 and 22, leading to the expression of constitutively active oncogenic BCR–ABL1 fusion prot…