Jan Palacký
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DNA i‐motif formation at physiological pH revealed by Raman spectroscopy Open
The intercalated motif (iM) is a four‐stranded structure consisting of two parallel homoduplexes formed by hemiprotonated C.C + pairs and intercalated antiparallel to each other. iM is generally formed at acidic pH, as cytosine protonation…
View article: Influence of Silicate Rock Glass Compositions on the Efficacy of Prebiotic RNA Polymerization Reactions: The Case of 3’,5’ Cyclic Guanosine Monophosphate
Influence of Silicate Rock Glass Compositions on the Efficacy of Prebiotic RNA Polymerization Reactions: The Case of 3’,5’ Cyclic Guanosine Monophosphate Open
Silicate glasses are ubiquitous on terrestrial planets wherever molten rock – generated by volcanism or impacts – is quenched by air or water. Hence, they provided ready and abundant reactive solid surfaces for prebiotic chemistry on the e…
DNA i-motif formation at neutral pH is driven by kinetic partitioning Open
Cytosine-rich DNA regions can form four-stranded structures based on hemi-protonated C.C+ pairs, called i-motifs (iMs). Using CD, UV absorption, NMR spectroscopy, and DSC calorimetry, we show that model (CnT3)3Cn (Cn) sequences adopt iM un…
Systematic investigation of sequence requirements for DNA i-motif formation Open
The formation of intercalated motifs (iMs) - secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is reflected by typical changes in CD and UV absorption spectra. By means of spectroscopic me…