Jan P. Vandenbroucke
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View article: Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: a comparison of England and Denmark using the OpenSAFELY platform and National Registry Data
Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: a comparison of England and Denmark using the OpenSAFELY platform and National Registry Data Open
Objectives To examine the impact of the COVID-19 pandemic on deprivation-related inequalities in hospitalisations for cardiovascular disease (CVD) conditions in Denmark and England between March 2018 and December 2021. Design Time-series s…
View article: The combined impact of migraine and gestational diabetes on long‐term risk of premature myocardial infarction and stroke: A population‐based cohort study
The combined impact of migraine and gestational diabetes on long‐term risk of premature myocardial infarction and stroke: A population‐based cohort study Open
Objective To examine the combined impact of migraine and gestational diabetes mellitus (GDM) on the risks of premature (persons aged ≤60 years) major adverse cardiovascular and cerebrovascular events (MACCE) based on a composite endpoint o…
View article: Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: A comparison of England and Denmark using the OpenSAFELY platform and National Registry Data
Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: A comparison of England and Denmark using the OpenSAFELY platform and National Registry Data Open
Objectives To examine the impact of the pandemic on deprivation-related inequalities in hospitalisations for CVD conditions in Denmark and England between March 2018 and December 2021. Design A series of monthly cross-sectional studies sep…
View article: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration — a Korean translation
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration — a Korean translation Open
의학 연구의 대부분은 관찰 연구이다. 관찰 연구의 보고는 종종 불충분한 품질을 보이기도 한다. 부실한 보고는 연구의 강점과 약점을 평가하고 연구 결과의 일반화 가능성을 평가하는 데 방해가 된다. 방법론 전문가, 연구자, 편집자 그룹은 경험적 근거와 이론적 고려 사항을 고려하여 관찰 연구 보고의 질을 개선하기 위한 역학 STROBE 권고안을 개발했다. STROBE statement은 논문의 제목, 초록, 서론, 방법, 결과 및…
View article: Correction: Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study
Correction: Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study Open
[This corrects the article DOI: 10.1371/journal.pmed.1004238.].
View article: Report on the Joint Workshop on the Relations between Health Inequalities, Ageing and Multimorbidity, Iceland, May 3–4, 2023
Report on the Joint Workshop on the Relations between Health Inequalities, Ageing and Multimorbidity, Iceland, May 3–4, 2023 Open
This paper is a summary of key presentations from a workshop in Iceland on May 3-4, 2023 arranged by Aarhus University and with participation of the below-mentioned scientists. Below you will find the key messages from the presentations ma…
View article: Risk factors for SARS-CoV-2 infection: a test-negative case–control study with additional population controls in Norway
Risk factors for SARS-CoV-2 infection: a test-negative case–control study with additional population controls in Norway Open
Objectives This study aims to assess risk factors for SARS-CoV-2 infection by combined design; first comparing positive cases to negative controls as determined by PCR testing and then comparing these two groups to an additional prepandemi…
View article: Combined Impact of Migraine and Pregnancy-Induced Hypertension on Long-term Risk of Premature Myocardial Infarction and Stroke
Combined Impact of Migraine and Pregnancy-Induced Hypertension on Long-term Risk of Premature Myocardial Infarction and Stroke Open
Migraine and PIH separately increased the risk of premature MACCE. The risk of premature MACCE among women who had both migraine and PIH was similar to that among women with PIH only.
View article: Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study
Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study Open
Background Migraine carries risk of myocardial infarction (MI) and stroke. The risk of premature MI (i.e., among young adults) and stroke differs between men and women; previous studies indicate that migraine is mainly associated with an i…
View article: Are Target Trial Emulations the Gold Standard for Observational Studies?
Are Target Trial Emulations the Gold Standard for Observational Studies? Open
There has been considerable debate in epidemiology about whether the randomized controlled trial (RCT) is the gold standard for epidemiologic studies; some of the debate is old, but some is new. Almost all are agreed that a well-conducted …
View article: Risk factors for SARS-CoV-2 infection: A test-negative case-control study with additional population controls
Risk factors for SARS-CoV-2 infection: A test-negative case-control study with additional population controls Open
Objectives To assess risk factors for SARS-CoV-2 infection by first comparing positive cases with negative controls as determined by polymerase chain reaction (PCR) testing and then comparing these two groups with an additional population …
View article: Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study
Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study Open
Cerebral venous thrombosis (CVT) predominantly affects young to middle-aged women. Scarce data exist regarding the long-term prognosis. We examined the clinical course of patients with CVT overall and according to their age and sex. Using …
View article: SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway
SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway Open
Objectives To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals and the possible pre…
View article: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration Open
Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taki…
View article: SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway
SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway Open
Objectives To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals and the possible pre…
View article: Tipping Points – Do the Prognostic Values of Multimorbidity and Functional Status Vary with Age?
Tipping Points – Do the Prognostic Values of Multimorbidity and Functional Status Vary with Age? Open
Aging of the population is a pressing challenge for healthcare systems and knowledge of a patient's prognosis is a key to shaping effective interventions. As the prevalence of multimorbidity strongly increases with age, the prognostic valu…
View article: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration Open
Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taki…
View article: The evolving usefulness of the Test-Negative Design in studying risk factors for COVID-19 due to changes in testing policy
The evolving usefulness of the Test-Negative Design in studying risk factors for COVID-19 due to changes in testing policy Open
This paper is a short extension of our previous paper [arXiv:2004.06033] about the use of the Test-Negative design to study risk factors for COVID-19 [See: PubMed and ArXiv reference below] Reason for the extension is that the conditions u…
View article: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration. Translation to Russian
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration. Translation to Russian Open
Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taki…
View article: Trends in Citations to Books on Epidemiological and Statistical Methods in the Biomedical Literature
Trends in Citations to Books on Epidemiological and Statistical Methods in the Biomedical Literature Open
BackgroundThere are no analyses of citations to books on epidemiological and statistical methods in the biomedical literature. Such analyses may shed light on how concepts and methods changed while biomedical research evolved. Our aim was …
View article: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration Open
Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taki…
View article: Why using algorithms for evidence synthesis is wrong: triangulation is needed
Why using algorithms for evidence synthesis is wrong: triangulation is needed Open
The concept that one should consider all of the available evidence in order to decide whether a particular exposure can cause a particular disease has been increasingly challenged in recent years, both scientifically and politically. The s…
View article: Community-Acquired <i>Escherichia coli</i> Bacteremia after Age 50 and Subsequent Incidence of a Cancer Diagnosis: A Danish Population–Based Cohort Study
Community-Acquired <i>Escherichia coli</i> Bacteremia after Age 50 and Subsequent Incidence of a Cancer Diagnosis: A Danish Population–Based Cohort Study Open
Background: Community-acquired bacteremia (CAB) with Escherichia coli may signal occult cancer. This might differ between phylogenetic groups. Methods: We conducted a population-based cohort study in northern Denmark (1994–2013) to examine…
View article: A Test-Negative Design with Additional Population Controls Can Be Used to Rapidly Study Causes of the SARS-CoV-2 Epidemic
A Test-Negative Design with Additional Population Controls Can Be Used to Rapidly Study Causes of the SARS-CoV-2 Epidemic Open
Testing of symptomatic persons for infection with severe acute respiratory syndrome coronavirus-2 is occurring worldwide. We propose two types of case–control studies that can be carried out jointly in test settings for symptomatic persons…
View article: Is death from Covid-19 a multistep process?
Is death from Covid-19 a multistep process? Open
Covid-19 death has a different relationship with age than is the case for other severe respiratory pathogens. The Covid-19 death rate increases exponentially with age, and the main risk factors are age itself, as well as having underlying …
View article: Accurate Statistics on COVID-19 Are Essential for Policy Guidance and Decisions
Accurate Statistics on COVID-19 Are Essential for Policy Guidance and Decisions Open
Disease surveillance forms the basis for response to epidemics. COVID-19 provides a modern example of why the classic mantra of “person, place, and time” remains crucial: epidemic control requires ...
View article: Exposure Opportunity: The Advantages of Including Men in Analyses of Female-Related Risk Factors
Exposure Opportunity: The Advantages of Including Men in Analyses of Female-Related Risk Factors Open
Intuitively, researchers do not include subjects who do not have the opportunity to be exposed, such as men in studies on oral contraceptives (OCs). We aimed to explore in which situations it is nevertheless beneficial to do so. We conside…