Jan Perner
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View article: Experimental evidence rules out mosquitoes as vectors of Lyme disease
Experimental evidence rules out mosquitoes as vectors of Lyme disease Open
Background Lyme disease, caused by Borrelia burgdorferi sensu lato (s.l.), is the most common vector-borne disease in the Northern Hemisphere, with Ixodes ticks as its primary vectors. However, many patients do not recall tick bites, fueli…
View article: Activation of the tick Toll pathway to control infection of Ixodes ricinus by the apicomplexan parasite Babesia microti
Activation of the tick Toll pathway to control infection of Ixodes ricinus by the apicomplexan parasite Babesia microti Open
The vector competence of blood-feeding arthropods is influenced by the interaction between pathogens and the immune system of the vector. The Toll and IMD (immune deficiency) signaling pathways play a key role in the regulation of innate i…
View article: The immune factors involved in the rapid clearance of bacteria from the midgut of the tick Ixodes ricinus
The immune factors involved in the rapid clearance of bacteria from the midgut of the tick Ixodes ricinus Open
Ticks are obligate hematophagous arthropods that transmit a wide range of pathogens to humans as well as wild and domestic animals. They also harbor a non-pathogenic microbiota, although our previous study has shown that the diverse bacter…
View article: Fipronil prevents transmission of Lyme disease spirochetes
Fipronil prevents transmission of Lyme disease spirochetes Open
Lyme disease, a tick-borne illness caused by Borrelia spirochetes, poses a significant threat to public health. While acaricides effectively control ticks on pets and livestock, their impact on pathogen transmission is often unclear. This …
View article: Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei Open
Haptoglobin is a plasma protein of mammals that plays a crucial role in vascular homeostasis by binding free haemoglobin released from ruptured red blood cells. Trypanosoma brucei can exploit this by internalising haptoglobin-haemoglobin c…
View article: Significant role of symbiotic bacteria in the blood digestion and reproduction of <i>Dermanyssus gallinae</i> mites
Significant role of symbiotic bacteria in the blood digestion and reproduction of <i>Dermanyssus gallinae</i> mites Open
Endosymbiotic bacteria significantly impact the fitness of their arthropod hosts. Dermanyssus gallinae, the poultry red mite, is a blood-feeding ectoparasite that exclusively feeds on avian blood. While there is a relatively comprehensive …
View article: Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks Open
The control of ticks through vaccination offers a sustainable alternative to the use of chemicals that cause contamination and the selection of resistant tick strains. However, only a limited number of anti-tick vaccines have reached comme…
View article: Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome
Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome Open
Ticks are ectoparasites that feed on blood and have an impressive ability to consume and process enormous amounts of host blood, allowing extremely long periods of starvation between blood meals. The central role in the parasitic lifestyle…
View article: Dual SIFamide receptors in Ixodes salivary glands
Dual SIFamide receptors in Ixodes salivary glands Open
Salivary glands are vital to tick feeding success and also play a crucial role in tick-borne pathogen transmission. In previous studies of Ixodes scapularis salivary glands, we demonstrated that saliva-producing type II and III acini are i…
View article: On the haem auxotrophy of the soft tick Ornithodoros moubata
On the haem auxotrophy of the soft tick Ornithodoros moubata Open
Genomes of ticks display reductions, to various extents, in genetic coding for enzymes of the haem biosynthetic pathway. Here, we mined available transcriptomes of soft tick species and identified transcripts encoding only half of the enzy…
View article: Ixodes ricinus ticks have a functional association with Midichloria mitochondrii
Ixodes ricinus ticks have a functional association with Midichloria mitochondrii Open
In addition to being vectors of pathogenic bacteria, ticks also harbor intracellular bacteria that associate with ticks over generations, aka symbionts. The biological significance of such bacterial symbiosis has been described in several …
View article: Babesia, Theileria, Plasmodium and Hemoglobin
Babesia, Theileria, Plasmodium and Hemoglobin Open
The Propagation of Plasmodium spp. and Babesia/Theileria spp. vertebrate blood stages relies on the mediated acquisition of nutrients available within the host’s red blood cell (RBC). The cellular processes of uptake, trafficking and metab…
View article: Integrative assessment of the transcriptome and virome of the poultry red mite <i>Dermanyssus gallinae</i>
Integrative assessment of the transcriptome and virome of the poultry red mite <i>Dermanyssus gallinae</i> Open
Dermanyssus gallinae is a blood-feeding mite that parasitises on wild birds and farmed poultry. The D. gallinae mite has a short life cycle of fewer than two weeks from the egg to an egg-laying female. The remarkably swift processing of bl…
View article: Lyme disease transmission by severely impaired ticks
Lyme disease transmission by severely impaired ticks Open
It has been demonstrated that impairing protein synthesis using drugs targeted against tRNA amino acid synthetases presents a promising strategy for the treatment of a wide variety of parasitic diseases, including malaria and toxoplasmosis…
View article: Haem-responsive gene transporter enables mobilization of host haem in ticks
Haem-responsive gene transporter enables mobilization of host haem in ticks Open
Ticks, notorious blood-feeders and disease-vectors, have lost a part of their genetic complement encoding haem biosynthetic enzymes and are, therefore, dependent on the acquisition and distribution of host haem. Solute carrier protein SLC4…
View article: The Central Role of Salivary Metalloproteases in Host Acquired Resistance to Tick Feeding
The Central Role of Salivary Metalloproteases in Host Acquired Resistance to Tick Feeding Open
During feeding on vertebrate hosts, ticks secrete saliva composed of a rich cocktail of bioactive molecules modulating host immune responses. Although most of the proteinaceous fraction of tick saliva is of little immunogenicity, repeated …
View article: Poor Unstable Midgut Microbiome of Hard Ticks Contrasts With Abundant and Stable Monospecific Microbiome in Ovaries
Poor Unstable Midgut Microbiome of Hard Ticks Contrasts With Abundant and Stable Monospecific Microbiome in Ovaries Open
Culture-independent metagenomic methodologies have enabled detection and identification of microorganisms in various biological systems and often revealed complex and unknown microbiomes. In many organisms, the microbiome outnumbers the ho…
View article: Histone Methyltransferase DOT1L Is Involved in Larval Molting and Second Stage Nymphal Feeding in Ornithodoros moubata
Histone Methyltransferase DOT1L Is Involved in Larval Molting and Second Stage Nymphal Feeding in Ornithodoros moubata Open
Epigenetic mechanisms have not been characterized in ticks despite their importance as vectors of human and animal diseases worldwide. Our investigation identifies and functionally characterizes the orthologue of S-adenosylmethionine (SAM)…
View article: Sialome diversity of ticks revealed by RNAseq of single tick salivary glands
Sialome diversity of ticks revealed by RNAseq of single tick salivary glands Open
Ticks salivate while feeding on their hosts. Saliva helps blood feeding through host anti-hemostatic and immunomodulatory components. Previous transcriptomic and proteomic studies revealed the complexity of tick saliva, comprising hundreds…
View article: RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks
RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks Open
Adult females of the genus Ixodes imbibe blood meals exceeding about 100 times their own weight within 7‒9 days. During this period, ticks internalise components of host blood by endocytic digest cells that line the tick midgut epithelium.…
View article: Acquisition of exogenous haem is essential for tick reproduction
Acquisition of exogenous haem is essential for tick reproduction Open
Haem and iron homeostasis in most eukaryotic cells is based on a balanced flux between haem biosynthesis and haem oxygenase-mediated degradation. Unlike most eukaryotes, ticks possess an incomplete haem biosynthetic pathway and, together w…
View article: Author response: Acquisition of exogenous haem is essential for tick reproduction
Author response: Acquisition of exogenous haem is essential for tick reproduction Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Haem and iron homeostasis in most eukaryotic ce…