Jan H. Reiling
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View article: MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis Open
View article: MYCN mediates cysteine addiction and sensitizes to ferroptosis
MYCN mediates cysteine addiction and sensitizes to ferroptosis Open
Aberrant expression of MYC family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYC induces massiv…
View article: Golgi stress mediates redox imbalance and ferroptosis in human cells
Golgi stress mediates redox imbalance and ferroptosis in human cells Open
View article: Golgi stress–induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing
Golgi stress–induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing Open
The secretory pathway is a major determinant of cellular homoeostasis. While research into secretory stress signaling has so far mostly focused on the endoplasmic reticulum (ER), emerging data suggest that the Golgi itself serves as an imp…
View article: Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1
Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1 Open
The Golgi apparatus is increasingly recognized as a major hub for cellular signaling and is involved in numerous pathologies, including neurodegenerative diseases and cancer. The study of Golgi stress-induced signaling pathways relies on t…
View article: Secretory stressors induce intracellular death receptor accumulation to control apoptosis
Secretory stressors induce intracellular death receptor accumulation to control apoptosis Open
View article: TRAPPC13 modulates autophagy and the response to Golgi stress
TRAPPC13 modulates autophagy and the response to Golgi stress Open
Tether complexes play important roles in endocytic and exocytic trafficking of lipids and proteins. In yeast, the multisubunit transport protein particle (TRAPP) tether regulates endoplasmic reticulum (ER)-to-Golgi and intra-Golgi transpor…
View article: Cell survival and protein secretion associated with Golgi integrity in response to Golgi stress‐inducing agents
Cell survival and protein secretion associated with Golgi integrity in response to Golgi stress‐inducing agents Open
The Golgi apparatus is part of the secretory pathway and of central importance for modification, transport and sorting of proteins and lipids. ADP ‐ribosylation factors, whose activation can be blocked by brefeldin A ( BFA ), play a major …