Ján Rosocha
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View article: Report on Amniotic Membrane for Surgery of Persistent Macular Hole
Report on Amniotic Membrane for Surgery of Persistent Macular Hole Open
Purpose: To evaluate the results of 3 cases with persistent macular holes (MH) treated by 23-gauge vitrectomy, extension of internal limiting membrane peeling, a human amniotic membrane (hAM) plug insertion into the subretinal space throug…
View article: The Role of Synovial Membrane in the Development of a Potential In Vitro Model of Osteoarthritis
The Role of Synovial Membrane in the Development of a Potential In Vitro Model of Osteoarthritis Open
There is a lack of in vitro models able to plausibly represent the inflammation microenvironment of knee osteoarthritis (OA). We analyzed the molecules released from OA tissues (synovial membrane, cartilage, infrapatellar fat pad) and inve…
View article: Mesenchymal Stem Cells in the Treatment of Human Spinal Cord Injury: The Effect on Individual Values of pNF-H, GFAP, S100 Proteins and Selected Growth Factors, Cytokines and Chemokines
Mesenchymal Stem Cells in the Treatment of Human Spinal Cord Injury: The Effect on Individual Values of pNF-H, GFAP, S100 Proteins and Selected Growth Factors, Cytokines and Chemokines Open
At present, there is no effective way to treat the consequences of spinal cord injury (SCI). SCI leads to the death of neural and glial cells and widespread neuroinflammation with persisting for several weeks after the injury. Mesenchymal …
View article: Small Extracellular Vesicles Derived from Human Chorionic MSCs as Modern Perspective towards Cell-Free Therapy
Small Extracellular Vesicles Derived from Human Chorionic MSCs as Modern Perspective towards Cell-Free Therapy Open
Mesenchymal stem cells (MSCs) are of great interest to scientists due to their application in cell therapy of many diseases, as well as regenerative medicine and tissue engineering. Recently, there has been growing evidence surrounding the…
View article: Effect of Intra-Articular Injection of Platelet-Rich Plasma on the Serum Levels of Osteoarthritic Biomarkers in Patients with Unilateral Knee Osteoarthritis
Effect of Intra-Articular Injection of Platelet-Rich Plasma on the Serum Levels of Osteoarthritic Biomarkers in Patients with Unilateral Knee Osteoarthritis Open
Background: The aim of this study is to determine the effect of three doses of intra-articular injection of platelet-rich plasma (PRP) into the osteoarthritic (OA) knee joint on the functional status and on the changes in the levels of spe…
View article: Characterization and Therapeutic Use of Extracellular Vesicles Derived from Platelets
Characterization and Therapeutic Use of Extracellular Vesicles Derived from Platelets Open
Autologous blood products, such as platelet-rich plasma (PRP), are gaining increasing interest in different fields of regenerative medicine. Although growth factors, the main components of PRP, are thought to stimulate reparation processes…
New therapeutic approaches of mesenchymal stem cells-derived exosomes Open
Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily cultured and manipulated. Rec…
View article: Aortic Reconstruction with Cryopreserved Human Allograft in a Hemodialysis Patient with Abdominal Aortic Aneurysm after Surgical Treatment of Liver Abscess
Aortic Reconstruction with Cryopreserved Human Allograft in a Hemodialysis Patient with Abdominal Aortic Aneurysm after Surgical Treatment of Liver Abscess Open
Infekcia v cievnej chirurgii je jedným z hlavných klinických problémov a pacienti s komorbiditami majú vyššie riziko infekčných komplikácií bez ohľadu na prístup k liečbe. Jednou skupinou su pacienti, ktorí majú graftinfekciu, kde radikáln…
View article: A Preliminary Study of Combined Detection of COMP, TIMP-1, and MMP-3 in Synovial Fluid: Potential Indicators of Osteoarthritis Progression
A Preliminary Study of Combined Detection of COMP, TIMP-1, and MMP-3 in Synovial Fluid: Potential Indicators of Osteoarthritis Progression Open
Objective Osteoarthritis (OA) commonly affects weight-bearing joints and is characterized by articular cartilage breakdown combined with osteophyte formation at the joint margins and chronic nonspecific inflammation of synovium. Understand…
View article: <i>In vitro</i> investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
<i>In vitro</i> investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers Open
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12-17 and urea heterodimers 18-22, and to measure interference with type I an…
View article: 3D printed Polylactid Acid based porous scaffold for bone tissue engineering: an in vitro study
3D printed Polylactid Acid based porous scaffold for bone tissue engineering: an in vitro study Open
The obtained PLA porous scaffolds favored attachment of periosteum derived progenitors and proliferation, furthermore, cells penetrated into the scaffold through the interstitial pores which was meaningful for cytocompatibility evaluation.
View article: Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment
Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment Open
Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and micr…
View article: (Infected thoracic stentgraft and prosthetic graft with replacement by human aortic allograft)
(Infected thoracic stentgraft and prosthetic graft with replacement by human aortic allograft) Open
Úvod: Popisujeme prípad úspešnej náhrady protézy descendentnej aorty a implantovaného hrudného stentgraftu humánnym aortálnym allograftom. Kazuistika: Jednalo sa o 47 ročného muža, ktorý bol v šestnástich rokoch operovaný pre koarktáciu ao…
View article: Influence of Kartogenin on Chondrogenic Differentiation of Human Bone Marrow-Derived MSCs in 2D Culture and in Co-Cultivation with OA Osteochondral Explant
Influence of Kartogenin on Chondrogenic Differentiation of Human Bone Marrow-Derived MSCs in 2D Culture and in Co-Cultivation with OA Osteochondral Explant Open
Articular cartilage has limited capacity for natural regeneration and repair. In the present study, we evaluated kartogenin (KGN), a bioactive small heterocyclic molecule, for its effect on in vitro proliferation and chondrogenic different…
View article: A Preliminary Study Comparing Microfracture and Local Adherent Transplantation of Autologous Adipose-Derived Stem Cells Followed by Intraarticular Injection of Platelet-Rich Plasma for the Treatment of Chondral Defects in Rabbits
A Preliminary Study Comparing Microfracture and Local Adherent Transplantation of Autologous Adipose-Derived Stem Cells Followed by Intraarticular Injection of Platelet-Rich Plasma for the Treatment of Chondral Defects in Rabbits Open
Objective This study aimed to compare microfracture and application of adipose-derived stem cells (ADSCs) by local adherent technique enhanced by platelet-rich plasma (PRP) to provide a new approach for the repair of cartilage defect. Desi…
View article: Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment
Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment Open
Human mesenchymal stem cells (MSCs) are considered to be a promising source of cells in regenerative medicine. They have large potential to differentiate into various tissue-specific populations and may be isolated from diverse tissues in …
View article: Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus Open
Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen, which can cause severe illnesses in humans. The most vulnerable are the human foetus and immunosuppressed individuals. Since there is no commercially available enzyme…