Explanipedia

A comprehensive dose-volume histogram-based index for radiotherapy treatment plan quality evaluation: application to breast cancer radiotherapy Open

Hiran C.G. Maladenige, Jan Seppälä, Tuomas Virén, Juuso T. J. Honkanen, Janne Heikkilä , et al. · 2025

Advances in radiotherapy have increased treatment plan complexity, making manual quality evaluation more subjective and variable. While deep learning approaches offer automation in planning, evaluation remains a manual bottleneck. Existing…

The benefit of DIBH on irradiated lung volume is overestimated in right-sided breast cancer VMAT with node involvement Open

Mikko Mankinen, Tuomas Virén, Jan Seppälä, Kristiina Vuolukka, Kimmo Myllyoja , et al. · 2025

Multicentre evaluation of deep learning CT autosegmentation of the head and neck region for radiotherapy Open

Eric Pei Ping Pang, Hong Qi Tan, Fuqiang Wang, Jarkko Niemelä, G. Bolard , et al. · 2025

Deep learning‐based prediction of the dose–volume histograms for volumetric modulated arc therapy of left‐sided breast cancer Open

Akseli Leino, Janne Heikkilä, Tuomas Virén, Juuso T. J. Honkanen, Jan Seppälä , et al. · 2024

Background The advancements in artificial intelligence and computational power have made deep learning an attractive tool for radiotherapy treatment planning. Deep learning has the potential to significantly simplify the trial‐and‐error pr…

Interfractional variation in whole-breast VMAT irradiation: a dosimetric study with complementary SGRT and CBCT patient setup Open

Mikko Mankinen, Tuomas Virén, Jan Seppälä, Timo Koivumäki · 2024

Background The dosimetric effect of setup uncertainty and tissue deformations in left-sided whole-breast irradiation with complementary surface-guided radiotherapy (SGRT) and cone-beam computed tomography (CBCT) setup was evaluated. Method…

The significance of free-hand needles in cervical cancer brachytherapy Open

Jan-Erik Palmgren, Jan Seppälä, Ester Jääskeläinen, Maarit Anttila · 2024

The utilization of FHNs resulted in higher dose coverage to HR-CTV, and lower doses to bladder and rectum. There was no difference in GTV, bowel, or vaginal point doses.

Previous radiotherapy improves treatment responses and causes a trend toward longer time to progression among patients with immune checkpoint inhibitor-related adverse events Open

Anna Jokimäki, Henna Hietala, Jasmiini Lemma, Hanna Karhapää, Anna Rintala , et al. · 2023

Background Immune-related adverse events (irAEs) are frequently encountered by patients during immune checkpoint inhibitor (ICI) treatment and are associated with better treatment outcomes. The sequencing of radiotherapy (RT) and ICIs is w…

Dosimetric effect of respiratory motion on planned dose in whole-breast volumetric modulated arc therapy using moderate and ultra-hypofractionation Open

Mikko Mankinen, Tuomas Virén, Jan Seppälä, Heikki Hakkarainen, Tuomas Koivumäki · 2022

Dosimetric Effect of Respiratory Motion On Planned Dose In Whole-Breast Volumetric Modulated Arc Therapy Using Standard And Ultra-Hypofractionation Open

Mikko Mankinen, Tuomas Virén, Jan Seppälä, Heikki Hakkarainen, Tuomas Koivumäki · 2021

Background and purpose: The interplay effects of respiratory motion and MLC movement on the planned dose in right-sided whole-breast irradiation (WBI) were studied by simulating hypofractionated VMAT treatment courses. Materials and method…

Is adaptive treatment planning for single-channel vaginal brachytherapy necessary? Open

Jan-Erik Palmgren, Jan Seppälä, Maarit Anttila · 2021

The analysis showed that, in order to cover distal part of the vaginal cuff, dose prescription should be a 10 mm from the tip of the applicator. Individualized image-based planning is recommended at least for first fraction. This would yie…

A Deep Learning-Based Automated CT Segmentation of Prostate Cancer Anatomy for Radiation Therapy Planning-A Retrospective Multicenter Study Open

Timo Kiljunen, Saad Ullah Akram, Jarkko Niemelä, Eliisa Löyttyniemi, Jan Seppälä , et al. · 2020

A commercial deep learning (DL)-based automated segmentation tool (AST) for computed tomography (CT) is evaluated for accuracy and efficiency gain within prostate cancer patients. Thirty patients from six clinics were reviewed with manual-…

Stereotactic body radiotherapy for localized prostate cancer – 5-year efficacy results Open

Kristiina Vuolukka, Päivi Auvinen, Erno Tiainen, Jan-Erik Palmgren, Janne Heikkilä , et al. · 2020

Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors Open

Tiina Remes, Maria Suo‐Palosaari, Päivi Koskenkorva, Anna Sutela, Sanna Toiviainen‐Salo , et al. · 2020

Dataset related to article "Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy" Open

Antonella Fogliata, Fiorenza De Rose, Davide Franceschini, A. Stravato, Jan Seppälä , et al. · 2019

This record contains raw data related to article "Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy" PURPOSE: To evaluate the e…

Dataset related to article "Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy" Open

Antonella Fogliata, Fiorenza De Rose, Davide Franceschini, A. Stravato, Jan Seppälä , et al. · 2019

This record contains raw data related to article "Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy" PURPOSE: To evaluate the e…

PO-0858 Dosimetric correlation analysis of observed toxicities in prostate cancer patients treated with SBRT Open

N. Pienimäki, Kristiina Vuolukka, Janne Heikkilä, Juni Palmgren, Jan Seppälä · 2019

OC-0193 Mobile application for daily patient scheduling during radiotherapy treatment course Open

Juha Kauppinen, M. Kokkonen, M. Kaunisto, Jan Seppälä · 2019

PO-1104 Implementing an automated target delineation service in multi-institutional environment in Finland Open

Jukka-Pekka Heikkilä, H. Virsunen, Leena Voutilainen, K. Vuolukka, A. Nevantaus , et al. · 2019

PO-0987 Rotational setup errors in breast cancer radiotherapy: the effect on treatment margins. Open

Jan Seppälä, Kristiina Vuolukka, Tuomas Virén, Janne Heikkilä, Juuso T. J. Honkanen , et al. · 2019

EP-2050: Geometrical uncertainties of humerus and breast in breast cancer radiotherapy Open

Juuso T. J. Honkanen, M. Loukkola, Jan Seppälä · 2018

EP-1855: Accuracy of MultiPlan Monte Carlo dose calculation algorithm to determine whole body mean dose Open

Tuomas Virén, Sisko Salomaa, Jan Seppälä · 2018

PO-0898: Second cancer induction risk from breast radiotherapy with VMAT and 3D conformal therapy Open

Antonella Fogliata, Fiorenza De Rose, Davide Franceschini, A. Stravato, Jan Seppälä , et al. · 2018

EP-2048: Surface changes during the course of breast cancer radiotherapy: effect on the in-air outer margin Open

Jan Seppälä, Awadhesh Kumar Pandey, A. Al-Gburi, Juuso T. J. Honkanen, Tuomas Virén , et al. · 2018

PO-0896: Accuracy of stereotactic body radiotherapy dose calculation algorithms outside treatment field Open

Tuomas Virén, Sisko Salomaa, Jan Seppälä · 2018

EP-1857: Feasibility of Gafchromic EBT3 film for measuring out-of-field dose in radiotherapy Open

Tuomas Virén, Aleksi Saikkonen, Jarkko Niemelä, Jani Keyriläinen, Sisko Salomaa , et al. · 2018

PO-0864: Accuracy of fiducial based correction of target motion in prostate SBRT treatments Open

Tuomas Virén, Miika Korhonen, Jan Seppälä · 2017

EP-1560: Left breast cancer planning with VMAT technique: the dosimetric trade-offs Open

Antonella Fogliata, Jan Seppälä, Giacomo Reggiori, F. Lobefalo, Vito Palumbo , et al. · 2017

A photographic technique for quick assessment of mechanical isocenter of a linear accelerator Open

Janne Heikkilä, Jan Seppälä, J. Nuutinen, Antti Vanne, Tapani Lahtinen · 2017

Geometrical uncertainty of heart position in deep-inspiration breath-hold radiotherapy of left-sided breast cancer patients Open

Tuomas Koivumäki, Juuso Tujunen, Tuomas Virén, Janne Heikkilä, Jan Seppälä · 2017

Residual variation was observed in the position of the heart in comparison to PTV, even with a visually guided DIBH technique. These geometrical uncertainties should be taken into account when planning radiotherapy treatment. The success o…

Surface doses of flattening filter free beams with volumetric modulated arc therapy dose delivery for breast cancer Open

Jan Seppälä, Aleksi Voutilainen, Janne Heikkilä, Marko Vauhkonen · 2017

Background and purpose: Flattening filter free (FFF) beams enable high-dose rate irradiations and have the potential to speed up breast cancer radiotherapy (RT) treatments. In this work the surface doses of FFF beams were studied with vari…

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