Jan Smida
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View article: Integrative multiomics study for validation of mechanisms in radiation-induced ischemic heart disease in Mayak workers
Integrative multiomics study for validation of mechanisms in radiation-induced ischemic heart disease in Mayak workers Open
Previous studies have suggested that exposure to ionizing radiation increases the risk of ischemic heart disease (IHD). The data from the Mayak nuclear worker cohort have indicated enhanced risk for IHD incidence. The goal of this study wa…
View article: The long non-coding RNA <i>PARTICLE</i> is associated with <i>WWOX</i> and the absence of FRA16D breakage in osteosarcoma patients
The long non-coding RNA <i>PARTICLE</i> is associated with <i>WWOX</i> and the absence of FRA16D breakage in osteosarcoma patients Open
Breakage of the fragile site FRA16D disrupts the WWOX (WW Domain Containing Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of breakage is not sufficient to explain the rate of WWOX loss in pathogenesis. The i…
View article: The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response
The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response Open
Generated by Quaking (QKI), circular RNAs (circRNAs) are newly recognised non-coding RNA (ncRNA) members characterised by tissue specificity, increased stability and enrichment within exosomes. Studies have shown that ionizing radiation (I…
View article: New Small Molecules Targeting Apoptosis and Cell Viability in Osteosarcoma
New Small Molecules Targeting Apoptosis and Cell Viability in Osteosarcoma Open
Despite the option of multimodal therapy in the treatment strategies of osteosarcoma (OS), the most common primary malignant bone tumor, the standard therapy has not changed over the last decades and still involves multidrug chemotherapy a…
View article: Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules
Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules Open
Osteosarcoma (OS), a bone tumor, exhibit a complex karyotype. On the genomic level a highly variable degree of alterations in nearly all chromosomal regions and between individual tumors is observable. This hampers the identification of co…
View article: <i>TP53</i> intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
<i>TP53</i> intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome Open
Somatic mutations of TP53 are among the most common in cancer and germline mutations of TP53 (usually missense) can cause Li-Fraumeni syndrome (LFS). Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in ost…