Jan‐Peter Sowa
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View article: The virtual doctor prescribing the future: Diagnostics with interactive clinical decision support
The virtual doctor prescribing the future: Diagnostics with interactive clinical decision support Open
The growing shortage of healthcare professionals, particularly in rural areas, poses a significant challenge to timely and effective medical care. To address this issue, we present the Virtual Doctor, a walk-in cabin designed to collect an…
View article: Limitations of Guideline‐Recommended Risk Stratification in Identifying <scp>MASLD</scp> Patients for Novel Drug Treatments
Limitations of Guideline‐Recommended Risk Stratification in Identifying <span>MASLD</span> Patients for Novel Drug Treatments Open
Current guidelines recommend FIB‐4 and transient elastography for non‐invasive risk stratification in metabolic dysfunction‐associated steatotic liver disease (MASLD). These tests can predict the presence or absence of advanced fibrosis, b…
View article: Non-Alcoholic Beer Influences Glucose and Lipid Metabolism and Changes Body Composition in Healthy, Young, Male Adults
Non-Alcoholic Beer Influences Glucose and Lipid Metabolism and Changes Body Composition in Healthy, Young, Male Adults Open
Background and Aims: Non-alcoholic beers (NABs) are gaining popularity as alternatives to alcoholic beverages, yet their metabolic and health effects compared to no consumption of these drinks remain unclear. Material and Methods: The inve…
View article: Increase of radiologically determined muscle area in patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt
Increase of radiologically determined muscle area in patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt Open
Sarcopenia is common in patients with liver cirrhosis and related to higher mortality. Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) is a feasible method for reducing cirrhosis-related portal hypertension, but also…
View article: Mechanisms and aetiology‐dependent treatment of acute liver failure
Mechanisms and aetiology‐dependent treatment of acute liver failure Open
This review compiles the mechanisms of acute liver failure (ALF) as well as the current and potential therapeutic approaches, including aetiology‐specific treatment, and the issues encountered with such approaches. On a cellular level, ALF…
View article: Higher pNRF2, SOCS3, IRF3, and RIG1 Tissue Protein Expression in NASH Patients versus NAFL Patients: pNRF2 Expression Is Concomitantly Associated with Elevated Fasting Glucose Levels
Higher pNRF2, SOCS3, IRF3, and RIG1 Tissue Protein Expression in NASH Patients versus NAFL Patients: pNRF2 Expression Is Concomitantly Associated with Elevated Fasting Glucose Levels Open
Non-alcoholic fatty liver disease (NAFLD) embraces simple steatosis in non-alcoholic fatty liver (NAFL) to advanced non-alcoholic steatohepatitis (NASH) associated with inflammation, fibrosis, and cirrhosis. NAFLD patients often have metab…
View article: Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed ‘Aging Cascade’
Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed ‘Aging Cascade’ Open
A transcriptome-wide analysis of human liver for demonstrating differences between young and old humans has not yet been performed. However, identifying major age-related alterations in hepatic gene expression may pinpoint ontogenetic shif…
View article: Creld2 function during unfolded protein response is essential for liver metabolism homeostasis
Creld2 function during unfolded protein response is essential for liver metabolism homeostasis Open
The unfolded protein response (UPR) is associated with hepatic metabolic function, yet it is not well understood how endoplasmic reticulum (ER) disturbance might influence metabolic homeostasis. Here, we describe the physiological function…
View article: GALAD Score Detects Early-Stage Hepatocellular Carcinoma in a European Cohort of Chronic Hepatitis B and C Patients
GALAD Score Detects Early-Stage Hepatocellular Carcinoma in a European Cohort of Chronic Hepatitis B and C Patients Open
Despite vaccination programs and direct antiviral treatments, the incidence of virus-related hepatocellular carcinoma (HCC) remains high, while ultrasound-based detection rates for early-stage HCC is continuously low. To address this insuf…
View article: Healthcare resource utilization and costs among nonalcoholic fatty liver disease patients in Germany
Healthcare resource utilization and costs among nonalcoholic fatty liver disease patients in Germany Open
NAFLD patients in Germany are grossly underdiagnosed and exert substantial healthcare resource use and economic burden, particularly those with advanced liver diseases. Optimal strategies for early identification and management are needed …
View article: Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD
Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD Open
The role of visceral white adipose tissue (vWAT) in the progression of non-alcoholic liver disease (NAFLD) with its sub entities non-alcoholic fatty liver and steatohepatitis (NAFL; NASH) is underinvestigated. We thus explored mechanisms o…
View article: Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD
Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD Open
The role of visceral white adipose tissue (vWAT) in the progression of non-alcoholic liver disease (NAFLD) with its sub entities non-alcoholic fatty liver and steatohepatitis (NAFL; NASH) is underinvestigated. We thus explored mechanisms o…
View article: Transaminase concentrations cannot separate NAFL and NASH in morbidly obese patients independent of histological algorithm
Transaminase concentrations cannot separate NAFL and NASH in morbidly obese patients independent of histological algorithm Open
Background: Prevalence of non-alcoholic fatty liver disease (NAFLD) in the German population is 20–30%. Liver biopsy to detect non-alcoholic steatohepatitis (NASH) let alone for NAFLD monitoring is not feasible. Current practice regards el…
View article: Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence
Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence Open
Non-alcoholic fatty liver disease (NAFLD) is defined clinicopathologically by the accumulation of lipids in >5% of hepatocytes and the exclusion of secondary causes of fat accumulation. NAFLD encompasses a wide spectrum of liver damage, ex…
View article: Patterns and predictors of mortality and disease progression among patients with non‐alcoholic fatty liver disease
Patterns and predictors of mortality and disease progression among patients with non‐alcoholic fatty liver disease Open
Summary Background Factors associated with mortality and disease progression in non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) are poorly understood. Aims To assess the impact of liver disease severity, …
View article: Creld2 function during unfolded protein response is essential for liver metabolism homeostasis
Creld2 function during unfolded protein response is essential for liver metabolism homeostasis Open
The unfolded protein response (UPR) is associated with the hepatic metabolic function, yet it is not well understood how endoplasmic reticulum (ER) disturbance might influence metabolic homeostasis. Here, we describe the physiological func…
View article: Supplementary Material for: Lipoprotein and Metabolic Profiles Indicate Similar Cardiovascular Risk of Liver Steatosis and NASH
Supplementary Material for: Lipoprotein and Metabolic Profiles Indicate Similar Cardiovascular Risk of Liver Steatosis and NASH Open
Background and Aim: Nonalcoholic fatty liver disease (NAFLD) affects about 25% of the global population, with no reliable noninvasive tests to diagnose nonalcoholic steatohepatitis (NASH) and to differentiate between NASH and nonalcoholic …
View article: Three Cases of Alcohol-Induced Acute-On-Chronic Liver Failure With Successful Support by Adipose-Derived Stem Cells
Three Cases of Alcohol-Induced Acute-On-Chronic Liver Failure With Successful Support by Adipose-Derived Stem Cells Open
OBJECTIVES: Acute liver failure (ALF) and acute-on-chronic liver failure (AOCLF) are critical medical conditions with urgent therapy requirements. When ALF or AOCLF are due to alcohol intoxication or based on chronic alcohol abuse, virtual…
View article: A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease
A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease Open
The PRTA-score is an accurate tool for detecting significant liver fibrosis in a broad range of liver disease aetiologies. FUND: Vrije Universiteit Brussel, the Institute for the Promotion of Innovation through Science and Technology in Fl…
View article: Non-invasive assessment of NAFLD as systemic disease—A machine learning perspective
Non-invasive assessment of NAFLD as systemic disease—A machine learning perspective Open
A newly developed model (http://CHek.heiderlab.de) can predict presence or absence of NASH with reasonable performance. The new score could be used to detect NASH and monitor disease progression or therapy response to weight loss intervent…
View article: Nonalcoholic-Fatty-Liver-Disease and Nonalcoholic Steatohepatitis: Successful Development of Pharmacological Treatment Will Depend on Translational Research
Nonalcoholic-Fatty-Liver-Disease and Nonalcoholic Steatohepatitis: Successful Development of Pharmacological Treatment Will Depend on Translational Research Open
Background: Nonalcoholic-fatty-liver-disease/nonalcoholic steatohepatitis (NAFLD/NASH) is expected to become the leading liver disease worldwide. Typical liver-related complications are fibrosis, cirrhosis, and the development of hepatocel…
View article: Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction
Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction Open
Non-invasive parameters, including liver and renal markers, can predict long-term outcome of patients after AMI.
View article: How to Define Acute Liver Failure Patients with Pre-Existing Liver Disease without Signs of Cirrhosis
How to Define Acute Liver Failure Patients with Pre-Existing Liver Disease without Signs of Cirrhosis Open
Background: The definition of acute liver failure (ALF) usually implies no previous liver injury. Though, some patients admitted to liver transplantation centers with the diagnosis of ALF are obese or have diabetes. Elevated liver enzymes …
View article: Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis
Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis Open
These findings indicate that the protective effect of Asm deficiency on diet-induced steatosis is conferred by alterations in adipocyte morphology and lipid metabolism and by reductions in Rictor activation.