Jan Stäcker
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View article: A system for functional studies of the major virulence factor of malaria parasites
A system for functional studies of the major virulence factor of malaria parasites Open
PfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite Plasmodium falciparum . PfEMP1 mediates binding of the infected cell to the endothelium of blood vessels, a cause of severe malaria. Each parasite en…
View article: An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells
An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells Open
Intracellular malaria blood stage parasites remodel their host cell, a process essential for parasite survival and a cause of pathology in malaria infections. Host cell remodeling depends on the export of different classes of exported para…
View article: An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells
An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells Open
Intracellular malaria blood stage parasites remodel their host cell, a process essential for parasite survival and a cause of pathology in malaria infections. Host cell remodeling depends on the export of different classes of exported para…
View article: A system for functional studies of the major virulence factor of malaria parasites
A system for functional studies of the major virulence factor of malaria parasites Open
Summary PfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite Plasmodium falciparum. PfEMP1 mediates binding of the infected cell to the endothelium of blood vessels, a cause of severe malaria. Each para…
View article: A system for functional studies of the major virulence factor of malaria parasites
A system for functional studies of the major virulence factor of malaria parasites Open
PfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite Plasmodium falciparum. PfEMP1 mediates binding of the infected cell to the endothelium of blood vessels, a cause of severe malaria. Each parasite enc…
View article: A system for functional studies of the major virulence factor of malaria parasites
A system for functional studies of the major virulence factor of malaria parasites Open
Summary PfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite Plasmodium falciparum . PfEMP1 mediates binding of the infected cell to the endothelium of blood vessels, a cause of severe malaria. Each par…
View article: PMRT1, a <i>Plasmodium</i> -Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development
PMRT1, a <i>Plasmodium</i> -Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development Open
Plasmodium falciparum -infected erythrocytes possess multiple compartments with designated membranes. Transporter proteins embedded in these membranes not only facilitate movement of nutrients, metabolites, and other molecules between thes…
View article: PMRT1, a<i>Plasmodium</i>specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development
PMRT1, a<i>Plasmodium</i>specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development Open
Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum , an agent of human malaria, relies on membrane transport proteins for the uptake of nutrients from the host, d…
View article: An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in <i>P. falciparum</i> infected red blood cells
An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in <i>P. falciparum</i> infected red blood cells Open
Intracellular malaria blood stage parasites remodel their host cell, a process essential for parasite survival and a cause of pathology in malaria infections. Host cell remodeling depends on the export of different classes of exported para…
View article: EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites
EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites Open
Intracellular malaria parasites grow in a vacuole delimited by the parasitophorous vacuolar membrane (PVM). This membrane fulfils critical roles for survival of the parasite in its intracellular niche such as in protein export and nutrient…