Explanipedia

Implantable loop recorder migration as cause of unexplained chronic chest pain Open

Niels Verlinde, Jan Van Keer, Roel Beelen · 2025

Comprehensive Non-invasive Versus Invasive Approach to Evaluate Cardiac Allograft Vasculopathy in Heart Transplantation: The CCTA-HTx Study Open

Marta Belmonte, Pasquale Paolisso, Michele Mattia Viscusi, Monika Beles, Luca Bergamaschi , et al. · 2025

BACKGROUND: Coronary computed tomography angiography (CCTA) is emerging as a valuable tool for noninvasive surveillance of cardiac allograft vasculopathy (CAV) in patients with heart transplant (HTx). We assessed the diagnostic performance…

Double bad luck: pulmonary embolism and vaginal bleeding - a case report Open

Sarah Shiba, Jan Van Keer · 2024

Background Pulmonary embolism is a common and potentially fatal condition. Exogenous estrogens in contraceptives are associated with an increased risk of venous thrombo-embolism. However, discontinuation of a combined oral contraceptive ca…

Double bad luck: pulmonary embolism and vaginal bleeding - a case report Open

Sarah Shiba, Jan Van Keer · 2023

Background: Pulmonary embolism is a common and potentially fatal condition. Exogenous estrogens in contraceptives are associated with an increased risk of venous thrombo-embolism. However, discontinuation of a combined oral contraceptive c…

The novel proteomic signature for the detection of cardiac allograft vasculopathy Open

Dongmei Wei, T Trenson, Jan Van Keer, Jesús D. Melgarejo, Lutgarde Thijs , et al. · 2021

Background Cardiac allograft vasculopathy (CAV) is the major long-term complications after heart transplantation, leading to mortality and re-transplantation. As available noninvasive biomarkers are scarce for CAV screening, we aimed to id…

Is degree of chronic illness management in heart transplant centers associated with better patient survival? Findings from the intercontinental BRIGHT study Open

Mia Cajita, Kris Denhaerynck, Lut Berben, Fabienne Dobbels, Johan Van Cleemput , et al. · 2021

Purpose To explore the association between the degree of Chronic illness management and survival rates at 1-, 3-, 5-years post heart transplantation. Methods Exploratory secondary analysis of a cross-sectional, international study (Buildin…

Can shear wave imaging distinguish between diffuse interstitial and replacement myocardial fibrosis? Open

Aniela Petrescu, Marta Cvijić, S Bezy, Pedro Santos, Jürgen Duchenne , et al. · 2021

Funding Acknowledgements Type of funding sources: None. Background Diffuse interstitial or myocardial replacement fibrosis are common features of a large variety of cardiomyopathies. These alterations contribute to functional changes, part…

Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation and association with mortality: a population-based study Open

Guillaume Bonnet, Guillaume Coutance, Jan Van Keer, Marc Raynaud, Olivier Aubert , et al. · 2020

Background Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient's mortality. However, the associations between CAV trajectories and mortality remains poorly described. Purpose We aimed to identify the d…

Shear wave elastography by high frame rate echocardiography can detect diffuse myocardial fibrosis after heart transplantation Open

Aniela Petrescu, S Bezy, Marta Cvijić, Polliana Batista dos Santos, J Duchenne , et al. · 2020

Background Myocardial fibrosis is fundamental in the development of cardiac failure, regardless of ethiology. In both animal models and humans it has been shown that diffuse myocardial fibrosis (DMF) contributes to functional impairment, e…

The effect of universal infant vaccination on the prevalence of hepatitis B immunity in adult solid organ transplant candidates Open

Özgür M. Koc, Dirk Kuypers, Lieven Dupont, Robin Vos, Jan Van Keer , et al. · 2020

Background Hepatitis B virus (HBV) immunity is recommended to optimize outcomes after solid organ transplantation (SOT). This study assessed the prevalence and predictors of HBV immunity at the time patients were placed on transplant waiti…

Shear Wave Elastography Using High-Frame-Rate Imaging in the Follow-Up of Heart Transplantation Recipients Open

Aniela Petrescu, S Bezy, Marta Cvijić, Pedro Santos, M Orlowska , et al. · 2020

Identification and Characterization of Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation Open

Alexandre Loupy, Guillaume Coutance, Guillaume Bonnet, Jan Van Keer, Marc Raynaud , et al. · 2020

Background: Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient mortality. Little is known about the prototypes of CAV trajectories at the population level. We aimed to identify the different evolution…

556 Shear wave imaging using ultra-high frame rate echocardiography for the assessment of structural changes in cardiac transplant recipients Open

Aniela Petrescu, S Bezy, Marta Cvijić, Pedro Santos, M Orlowska , et al. · 2020

Background Cardiac allografts undergo characteristic alterations of the extracellular matrix, including myocardial fibrosis, that contribute to functional changes, particularly diastolic dysfunction due to increased myocardial stiffness(MS…

Cannabis-Induced Third-Degree AV Block Open

Jan Van Keer · 2019

Background. Cannabis (marijuana) is the most widely consumed illicit drug in Europe. However, many are unaware of its potential cardiovascular side effects. Case Report. A 19-year-old man presented to the emergency department with palpitat…

Idarucizumab for the reversal of dabigatran in patients undergoing heart transplantation Open

Jan Van Keer, Thomas Vanassche, Walter Droogné, Steffen Rex, Filip Rega , et al. · 2018

Atrial fibrillation is common among patients with advanced heart failure who are listed for transplantation.1 The choice of anticoagulation in these patients can be challenging. Compared with vitamin K antagonists (VKAs), non-vitamin K ora…

Retinal oxygen saturation as a non‐invasive estimate for mixed venous oxygen saturation and cardiac output Open

Karel Van Keer, Jan Van Keer, João Barbosa‐Breda, Vahid Nassiri, Johan Van Cleemput , et al. · 2018

Purpose To investigate the correlation between retinal vessel oxygen saturation and mixed venous oxygen saturation (SvO 2‐mixed ) and cardiac output ( CO ). Methods Retinal arterial (SaO 2‐retinal ) and venous (SvO 2‐retinal ) oxygen satur…

Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients Open

Qi‐Fang Huang, Jan Van Keer, Zhen‐Yu Zhang, Sander Trenson, Esther Nkuipou‐Kenfack , et al. · 2018

BB use, but not HR, is associated with a urinary proteomic signature that is usually associated with worse outcome, because unhealthier conditions probably lead to initiation of BB. Starting BB early after HTx surgery might be beneficial.

Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study Open

Zhen‐Yu Zhang, Vannina G. Marrachelli, Wen‐Yi Yang, Sander Trenson, Qi‐Fang Huang , et al. · 2018

Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population. Methods and results In 570 randomly recruited peopl…

P879Myocardial proteomic signatures in end-stage dilated and ischemic cardiomyopathy compared with normal human hearts Open

Z Y Zhang, Sander Trenson, Wen‐Yi Yang, Jérôme Zoidakis, Esther Nkuipou‐Kenfack , et al. · 2018

Results: Measures of LA phasic function were more prominently impaired in subjects with HFrEF, than among subjects with HFpEF.In unadjusted Cox proportional hazards models, all measures of phasic LA function and volumes (maximum, minimum a…

Urinary peptidomic biomarkers of renal function in heart transplant recipients Open

Qi‐Fang Huang, Zhen‐Yu Zhang, Jan Van Keer, Sander Trenson, Esther Nkuipou‐Kenfack , et al. · 2018

Background Chronic kidney disease (CKD) is common in patients after heart transplantation (HTx). We assessed whether in HTx recipients the proteomic urinary classifier CKD273 or sequenced urinary peptides revealing the parental proteins co…

Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study Open

Qi‐Fang Huang, Sander Trenson, Zhen‐Yu Zhang, Jan Van Keer, Lucas Van Aelst , et al. · 2018

Background This proof-of-concept study investigated the feasibility of using biomarkers to monitor right heart pressures (RHP) in heart transplanted (HTx) patients. Methods In 298 patients, we measured 7.6 years post-HTx mean pressures in …

Conventional and Ambulatory Blood Pressure as Predictors of Diastolic Left Ventricular Function in a Flemish Population Open

Fang‐Fei Wei, Wen‐Yi Yang, Lutgarde Thijs, Zhen‐Yu Zhang, Nicholas Cauwenberghs , et al. · 2018

Background No longitudinal study compared associations of echocardiographic indexes of diastolic left ventricular function studies with conventional ( CBP ) and daytime ambulatory ( ABP ) blood pressure in the general population. Methods a…

Non-invasive assessment of cerebral oxygenation: A comparison of retinal and transcranial oximetry Open

Karel Van Keer, Jan Van Keer, João Barbosa‐Breda, Vahid Nassiri, C. De Deyne , et al. · 2018

This is the first study to show the correlation between retinal and cerebral oxygen saturation, measured by NIRS and retinal oximetry. The average relative weight of arterial and venous retinal oxygen saturation to obtain the measured tran…

The CECARI Study: Everolimus (Certican®) Initiation and Calcineurin Inhibitor Withdrawal in Maintenance Heart Transplant Recipients with Renal Insufficiency: A Multicenter, Randomized Trial Open

Jan Van Keer, David Derthoo, Olivier Van Caenegem, Michel De Pauw, Eric Nellessen , et al. · 2017

In this 3-year, open-label, multicenter study, 57 maintenance heart transplant recipients (>1 year after transplant) with renal insufficiency (eGFR 30–60 mL/min/1.73 m 2 ) were randomized to start everolimus with CNI withdrawal () or conti…

Proteasome inhibitor associated thrombotic microangiopathy Open

Jennifer C. Yui, Jan Van Keer, Brendan M. Weiss, Adam Waxman, Matthew B. Palmer , et al. · 2016

A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with m…

Two Cases of Heavy Chain MGUS Open

Jan Van Keer, Björn Meijers, Michel Delforge, Gregor Verhoef, Koen Poesen · 2016

Heavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains. We describe two patients with asymptomatic heavy chain monoclonal gammopathy. …

Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma Open

Jan Van Keer, Michel Delforge, Daan Dierickx, Kathelijne Peerlinck, Evelyne Lerut , et al. · 2016

Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-prov…

Purple Urine Bag Syndrome in Two Elderly Men with Urinary Tract Infection Open

Jan Van Keer, Daan Detroyer, Bert Bammens · 2015

Purple urine bag syndrome is a rare condition in which purple discoloration of urine inside its collection bag occurs. We describe two illustrative cases. The first patient is an 81-year-old man who was hospitalized for a newly diagnosed l…

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