Explanipedia

Distinct Morphological Types of Small Airway Obstructions in Smokers with Emphysema and End-Stage Chronic Obstructive Pulmonary Disease Open

Vincent Geudens, Charlotte De Fays, Lynn Willems, Astrid Vermaut, Gitte Aerts , et al. · 2025

Rationale: The precise nature of small airway obstructions in chronic obstructive pulmonary disease (COPD) remains poorly understood, especially at early disease stages. Objectives: This study aimed to characterize small airw…

Lung transplantation from a 94-year-old donor: A debate on biological versus chronological age Open

Jan Van Slambrouck, Cedric Vanluyten, Anabelle Decottignies, Manon Mahieu, Bernard R. Schockaert , et al. · 2025

Lung transplantation is challenged by a critical shortage of donors, prompting the extension of acceptance criteria, including donor age. Here, we report on a double-lung transplantation from a 94-year-old donor. Despite the advanced age, …

The Nationwide Impact of COVID‐19 on Lung Donation and Transplantation in Belgium Open

Jan Van Slambrouck, Robin Vos, Isabelle Étienne, François Carlier, Veronique Verplancke , et al. · 2025

SARS‐CoV‐2 primarily infects the respiratory tract. Consequently, lung transplantation (LTx) programs have been significantly impacted by the COVID‐19 pandemic. This study aimed to summarize the impact of the pandemic on LTx in Belgium. Eu…

Temperature Dynamics of Porcine and Human Lungs During Static Ice Storage: Ice Is Not 4 °C Open

Ismail Cenik, Jan Van Slambrouck, Annalisa Barbarossa, Xin Jin, An‐Lies Provoost , et al. · 2025

Background: Static ice storage (SIS) has long been accepted as the conventional lung preservation method, assuming to maintain 4 °C temperature. Although never directly confirmed by temperature measurements, this assumption has been widely…

Temperature Dynamics of Porcine and Human Lungs During Static Ice Storage: Ice Is Not 4°C Open

Ismail Cenik, Jan Van Slambrouck, Annalisa Barbarossa, Xin Jin, An‐Lies Provoost , et al. · 2025

Static ice storage (SIS) is the historic standard for lung preservation. It has been assumed that SIS results in 4°C organ temperatures. However, no prior studies measured lung temperature during SIS, potentially reaching near-freezing con…

The thoracic surgeon perspective—lung transplantation in controlled donation after circulatory determination of death: any conflict with the heart? Open

Dirk Van Raemdonck, Janne Brouckaert, Jan Van Slambrouck, Katrien Vandendriessche, Laurens J. Ceulemans , et al. · 2024

Donor-Specific Blood Transfusion in Lung Transplantation Open

Xin Jin, Jacques Pirenne, Robin Vos, Charlotte Hooft, Janne Kaes , et al. · 2024

Lung transplantation is still hindered by a high rate of chronic rejection necessitating profound immunosuppression with its associated complications. Donor-specific blood transfusion is a pre-transplant strategy aimed at improving graft a…

Phenotyping of primary graft dysfunction after lung transplantation by in-depth biomarker analysis Open

Birger Tielemans, Jan Van Slambrouck, Balin Özsoy, Laurens J. Ceulemans · 2024

This editorial highlights the importance of research towards PGD-specific biomarkers, suggesting strategic sample collection and advanced analysis techniques to expand our knowledge of PGD mechanisms and potential phenotyping https:…

Lung transplantation following controlled hypothermic storage with a portable lung preservation device: first multicenter European experience Open

An‐Lies Provoost, René Novysedlák, Dirk Van Raemdonck, Jan Van Slambrouck, Elena Prisciandaro , et al. · 2024

Introduction Compared with traditional static ice storage, controlled hypothermic storage (CHS) at 4–10°C may attenuate cold-induced lung injury between procurement and implantation. In this study, we describe the first European lung trans…

Controlled Hypothermic Storage for Lung Preservation: Leaving the Ice Age Behind Open

Ismail Cenik, Jan Van Slambrouck, An‐Lies Provoost, Annalisa Barbarossa, Cedric Vanluyten , et al. · 2024

Controlled hypothermic storage (CHS) is a recent advance in lung transplantation (LTx) allowing preservation at temperatures higher than those achieved with traditional ice storage. The mechanisms explaining the benefits of CHS compared to…

Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma Open

Tom Vandaele, Jan Van Slambrouck, Patrick Schöffski, Herlinde Dumez, Birgit Weynand , et al. · 2024

Successful Lung Transplantation from a 94-Years-Old Donor Questions the Discussion on Calendar versus Biological Age Open

Jan Van Slambrouck, An‐Lies Provoost, B Schockaert, Annalisa Barbarossa, Charlotte Van Der Stukken , et al. · 2024

Diagnosis and Management of Esophageal Fistulas After Lung Transplantation: A Case Series Open

Stijn Vanstraelen, Robin Vos, Marie Dausy, Jan Van Slambrouck, Cedric Vanluyten , et al. · 2024

Background. Lung transplantations are highly complex procedures, often conducted in frail patients. Through the addition of immunosuppressants, healing can be compromised, primarily leading to the development of bronchopleural fistulas. Al…

Ventilatory capacity in CLAD is driven by dysfunctional airway structure Open

Pieterjan Kerckhof, Gene Philip Louie Ambrocio, Hanne Beeckmans, Janne Kaes, Vincent Geudens , et al. · 2024

The Immunopathology of Pulmonary Rejection after Murine Lung Transplantation Open

Janne Kaes, Emilie Pollenus, Charlotte Hooft, Hengshuo Liu, Céline Aelbrecht , et al. · 2024

To improve outcomes following lung transplantation, it is essential to understand the immunological mechanisms that result in chronic graft failure. The associated clinical syndrome is termed chronic lung allograft dysfunction (CLAD), whic…

Extensive surgical resections for rare pleural neoplasms: A single-center experience with a yolk sac tumor and synovial sarcoma. Open

Tom Vandaele, Jan Van Slambrouck, Patrick Schöffski, Herlinde Dumez, Birgit Weynand , et al. · 2023

Background: Pleural neoplasms are rare and can be subdivided into pleural metastasis and primary pleural neoplasms. Non-mesothelioma primary pleural neoplasms are a diverse group of extremely rare pathologies. Case presentation: In this ca…

Complications related to extracorporeal life support in lung transplantation: single-center analysis Open

Michaela Orlitová, Wout Goos, Jan Van Slambrouck, Karlien Degezelle, Cedric Vanluyten , et al. · 2023

ECLS was required in 22% of LTxs, with a reported ECLS-related complication rate of 67%, of which the most common was hemothorax. Larger databases are needed to further analyze complications and develop tailored deployment strategies for E…

Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease Open

Charlotte de Fays, Vincent Geudens, Iwein Gyselinck, Pieterjan Kerckhof, Astrid Vermaut , et al. · 2023

Rationale COPD is characterized by chronic airway inflammation, small airways changes, with disappearance and obstruction, and also distal/alveolar destruction (emphysema). The chronology by which these three features evolve with altered m…

Off-pump lung re-transplantation avoiding clamshell thoracotomy is feasible and safe: a single-center experience Open

Xin Jin, Cedric Vanluyten, Michaela Orlitová, Jan Van Slambrouck, Robin Vos , et al. · 2023

Our experience shows that clamshell-avoiding off-pump re-LTx is feasible and safe in selected patients on a case-by-case evaluation.

The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: a translational porcine model Open

Michaela Orlitová, Tom Verbelen, Anna E. Frick, Arno Vanstapel, Dieter Van Beersel , et al. · 2023

In contrast to the abundant literature of mechanical pulmonary artery clamping to increase right ventricular afterload, we developed a model adding a biological factor of pulmonary ischemia-reperfusion injury. We did not only focus on the …

COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT Open

Vincent Geudens, Jan Van Slambrouck, Gitte Aerts, Lynn Willems, Tinne Goos , et al. · 2023

COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology.

Visualising SARS-CoV-2 infection of the lung in deceased COVID-19 patients Open

Jan Van Slambrouck, Mona Khan, Erik Verbeken, Sumin Choi, Vincent Geudens , et al. · 2023

Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation Open

Hanne Beeckmans, Elfri Van Roy, Janne Kaes, Annelore Sacreas, Vincent Geudens , et al. · 2023

Fungal exposure and sensitization negatively affect outcomes in various respiratory diseases, however, the effect of fungal sensitization in lung transplant (LTx) recipients is still unknown. We performed a retrospective cohort study of pr…

Lung Transplant Outcome From Selected Older Donors (≥70 Years) Equals Younger Donors (<70 Years) Open

Cedric Vanluyten, Christelle M. Vandervelde, Robin Vos, Jan Van Slambrouck, Steffen Fieuws , et al. · 2023

Objective: To describe our experience with lung transplantation (LTx) from donors ≥70 years and compare short and long-term outcomes to a propensity-matched cohort of donors <70 years. Background: Although extended-criteria donors have bee…

Commentary: Genetic modulation in lung transplantation: Epic odyssey of vector transduction and transgene expression Open

Jan Van Slambrouck, Marianne S. Carlon, Dirk Van Raemdonck, Laurens J. Ceulemans · 2022

Endovascular transatrial stenting of pulmonary vein stenosis after lung transplantation Open

Michaela Orlitová, Marc Gewillig, Jan Van Slambrouck, Dirk Vlasselaers, Bart Jacobs , et al. · 2022

Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma Open

Viktor Proesmans, Tom Vandaele, Jan Van Slambrouck, Albert Wolthuis, André D ́Hoore , et al. · 2022

Aim: Pleural dissemination of pseudomyxoma peritonei (PMP) is an extremely rare diagnosis, for which no standard therapy is available.Methods: We describe the successful treatment of a 67-year-old male diagnosed with left-sid…

Donor lung preservation for transplantation—where do we go from here? Open

Dirk Van Raemdonck, Jan Van Slambrouck, Laurens J. Ceulemans · 2022

Gamma-glutamyltransferase is a strong predictor of secondary sclerosing cholangitis after lung transplantation for COVID-19 ARDS Open

Stefan Schwarz, Christian Lang, Matevž Harlander, Tomaž Štupnik, Jan Van Slambrouck , et al. · 2022

SSC-CIP is a severe late complication after LTx for COVID-19 ARDS leading to significant morbidity and mortality. GGT appears to be a sensitive parameter able to predict SSC-CIP even at the time of listing.

Lung Volume Reduction Followed by Lung Transplantation in Emphysema—A Multicenter Matched Analysis Open

Alexis Slama, Laurens J. Ceulemans, Celia Hedderich, Panja M. Boehm, Jan Van Slambrouck , et al. · 2022

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