Jan Verner
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Creatine kinase B, a downstream effector of c-Myb, controls migration of osteosarcoma cells via regulation of N-cadherin Open
Background We have recently identified transcription factor c-Myb as a negative prognostic factor in osteosarcoma (OSA) patients associated with metastatic disease. Transcriptomic analysis identified creatine kinase B ( CKB ) as one of the…
View article: Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs
Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs Open
Several in vitro models have been developed to mimic chronic lymphocytic leukemia (CLL) proliferation in immune niches; however, they typically do not induce robust proliferation. We prepared a novel model based on mimicking T-cell signals…
Data from The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration Open
The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein…
Supplementary Methods and Figures 1 - 6 from The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration Open
PDF file - 695K, S. figure 1mRNA from CD19+ cells of healthy individuals. S. figure 2 Expression of Wnt-5a in the samples shown in Fig. 1 was determined by qRT-PCR. S. figure 3 Viability of primary CLL cells stimulated with the indicated c…
Data from The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration Open
The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein…
Supplementary Methods and Figures 1 - 6 from The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration Open
PDF file - 695K, S. figure 1mRNA from CD19+ cells of healthy individuals. S. figure 2 Expression of Wnt-5a in the samples shown in Fig. 1 was determined by qRT-PCR. S. figure 3 Viability of primary CLL cells stimulated with the indicated c…
View article: Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro
Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro Open
Background Anti-CD19 chimeric antigen receptor T cells (CART-19) frequently induce remissions in hemato-oncological patients with recurred and/or refractory B-cell tumors. However, malignant cells sometimes escape the immunotherapeutic tar…
FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia Open
Recirculation of chronic lymphocytic leukemia (CLL) cells between the peripheral blood and lymphoid niches plays a critical role in disease pathophysiology, and inhibiting this process is one of the major mechanisms of action for B-cell re…
Volatile organic compounds in motor vehicle interiors under various conditions and their effect on human health Open
The aim of this paper is to estimate the mass concentrations of volatile organic compounds (VOCs) such as benzene (B), toluene (T), ethylbenzene (E) and m-, p-, o-xylenes (X) inside of the driver-compartment of motor vehicles. The results …
View article: Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia
Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia Open
Background While achieving prolonged remissions in other B cell-derived malignancies, chimeric antigen receptor (CAR) T cells still underperform when injected into patients with chronic lymphocytic leukemia (CLL). We studied the influence …
System allowing adhesion force change of road vehicle Open
Bringing the car into a skid is realised by the adhesion force decrease. This can be reached either by a coefficient of adhesion decrease or decrease of a radial reaction on the vehicle’s wheel. For the purpose to the vehicle’s behaviour c…
REDUCING THE ADHESION FORCE OF THE WHEELS OF THE ROAD VEHICLES Open
The article deals with influence of the controlled adhesion force in the contact between a wheel of a road vehicle and a road. In the first section, a way to reach a decrease of adhesion force is presented. Then follows description of the …
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells Open
Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic leukemia. However, some patients suffer from adverse effects mandating treatment disc…
Preference and area coordination of public transport in modern city Open
The purpose of the document is to analyse and evaluate the situation in the field of chronometrations of the town’s public transport company Dopravní společnost Zlín-Otrokovice (DSZO) in the Czech Republic in relation to the project “Prefe…
Comparison of CVS and PEMS measuring devices used for stating CO<sub>2</sub> exhaust emissions of light-duty vehicles during WLTP testing procedure Open
In 2014, the United Nations Economic Commission for Europe (UNECE) released the Worldwide Harmonized Light-Duty Vehicles Test Procedure (WLTP). The European Commission focused on introducing a new trial test procedure into the European leg…
Comparison of electricity and fossil fuel consumption in trolleybuses and buses Open
In the paper there are results presented of yearlong testing of operation of a trolleybus Škoda 26Tr Solaris, which is equipped with energy storage lithium-titanate traction battery using nanocrystals (nLTO). The trolleybus has been in ope…
Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia Open
Key Points CK1 inhibition significantly blocks microenvironmental interactions of CLL cells. CK1 inhibition slows down development of CLL-like disease in the Eμ-TCL1 mouse model.
Efficiency Assessment of Fuel Borne Catalyst Open
Fuel additives are offered to motorists at petrol stations and on the internet. Cerium or iron in the form of ferrocene is often used as a catalytically active metal in these additives. Producers of these fuels borne catalyst declare that …
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells Open
Treatment options for TP53-mutated lymphoid tumors are very limited. In experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of checkpoint kinase 1 (Chk1), a pivotal regulator of replication. We initially tested …