Jan Weber
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View article: Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on <i>N</i> , <i>N′</i> ‐Diphenylurea
Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on <i>N</i> , <i>N′</i> ‐Diphenylurea Open
The COVID‐19 pandemic, caused by the highly transmissible SARS‐CoV‐2 virus, has highlighted the urgent need for effective small‐molecule antivirals. To date, only a few such agents, including molnupiravir and remdesivir, have been approved…
View article: Scaled-up non-thermal plasma-generating device Plasmatico enables effective and harmless disinfection of personal protective equipment
Scaled-up non-thermal plasma-generating device Plasmatico enables effective and harmless disinfection of personal protective equipment Open
The COVID-19 pandemic highlighted the urgent need to find effective methods for disinfecting items such as personal protective equipment (PPE) in case a similar situation occurs in the future. To address this problem, we selected FFP2 mask…
View article: UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of hepatitis B virus maturation and egress
UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of hepatitis B virus maturation and egress Open
A critical step in Hepatitis B virus (HBV) maturation and egress is the ubiquitination of the capsid/core protein (HBc), which enables its recognition by the endosomal sorting complex required for transport (ESCRT) machinery and recruitmen…
View article: Synthesis of 3′-modified xylofuranosyl nucleosides bearing 5′-silyl or -butyryl groups and their antiviral effect against RNA viruses
Synthesis of 3′-modified xylofuranosyl nucleosides bearing 5′-silyl or -butyryl groups and their antiviral effect against RNA viruses Open
D-xylofuranosyl nucleoside analogues bearing alkylthio and glucosylthio substituents at the C3'-position were prepared by photoinitiated radical-mediated hydrothiolation reactions from the corresponding 2',5'-di-O-silyl-3'-exomethylene uri…
View article: Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates
Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates Open
Hydrogen sulfide (H 2 S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H 2 S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a…
View article: The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery Open
View article: Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects
Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects Open
The most successful structures showing their antimicrobial, antiviral or cytotoxic effects. Selectivity of their effects has been observed.
View article: Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5’-dithioacetates
Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5’-dithioacetates Open
Hydrogen sulfide (H2S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H2S-donor hybrid molecules were prepared by conjugating nucleoside b…
View article: 3D-printed devices for optimized generation of cold atmospheric plasma to improve decontamination of surfaces from respiratory pathogens
3D-printed devices for optimized generation of cold atmospheric plasma to improve decontamination of surfaces from respiratory pathogens Open
Three-dimensional (3D)-printing technology is instrumental in creating devices for biological applications, including the exploitation of cold atmospheric plasma (CAP). CAP, a partially ionized gas that functions at ambient temperatures, s…
View article: Developing Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase
Developing Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Open
The use of Fpocket and virtual screening techniques enabled us to identify potential allosteric druggable pockets within the SARS‐CoV‐2 RNA‐dependent RNA polymerase (RdRp). Of the compounds screened, compound 1 was identified as a promisin…
View article: Effect of multifunctional cationic polymer coatings on mitigation of broad microbial pathogens
Effect of multifunctional cationic polymer coatings on mitigation of broad microbial pathogens Open
Infection control measures to prevent viral and bacterial infection spread are critical to maintaining a healthy environment. Pathogens such as viruses and pyogenic bacteria can cause infectious complications. Viruses such as SARS-CoV-2 ar…
View article: HIV-1 Infection Reduces NAD Capping of Host Cell snRNA and snoRNA
HIV-1 Infection Reduces NAD Capping of Host Cell snRNA and snoRNA Open
Nicotinamide adenine dinucleotide (NAD) is a critical component of the cellular metabolism and also serves as an alternative 5' cap on various RNAs. However, the function of the NAD RNA cap is still under investigation. We studied NAD capp…
View article: Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells
Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells Open
Adhesion G protein-coupled receptors (aGPCRs) play an important role in neurodevelopment, immune defence and cancer; however, their role throughout viral infections is mostly unexplored. We have been searching for specific aGPCRs involved …
View article: Stability and biological response of PEGylated gold nanoparticles
Stability and biological response of PEGylated gold nanoparticles Open
View article: Block Synthesis and Step-Growth Polymerization of C-6-Sulfonatomethyl-Containing Sulfated Malto-Oligosaccharides and Their Biological Profiling
Block Synthesis and Step-Growth Polymerization of C-6-Sulfonatomethyl-Containing Sulfated Malto-Oligosaccharides and Their Biological Profiling Open
Highly sulfated malto-oligomers, similar to heparin and heparan-sulfate, have good antiviral, antimetastatic, anti-inflammatory and cell growth inhibitory effects. Due to their broad biological activities and simple structure, sulfated mal…
View article: Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents
Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents Open
Less frequently studied plant triterpenoids betulonic acid and platanic acid were selected to design, synthesize and investigate their oxime derivatives as novel and potentially effective cytotoxic and/or antiviral agents.
View article: Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes
Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes Open
Workflow used for identifying inhibitors of the SARS-CoV-2 non-structural protein 14 (nsp14), a key player in viral RNA methylation.
View article: Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides Open
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides.
View article: Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives
Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives Open
(−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral b…
View article: Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors
Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors Open
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant global morbidity and mortality. A crucial viral protein, the non-structural protein 14 (nsp14), catalyzes the methylation of viral RNA and plays a critical role …
View article: Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus
Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus Open
The RNA 2'-O methyltransferase (MTase) VP39 of the monkeypox virus (MpxV) participates in RNA capping within poxviruses. Sub-micromolar inhibitors targeting this enzyme were already reported. However, these 7-deaza analogs of S-adenosyl me…
View article: Mannich-Type Modifications Of (-)-Cannabidiol And (-)-Cannabigerol Leading To New, Bioactive Derivatives
Mannich-Type Modifications Of (-)-Cannabidiol And (-)-Cannabigerol Leading To New, Bioactive Derivatives Open
(‑)-Cannabidiol (CBD) and (‑)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral b…
View article: Textile Coated with Mercaptoethane Sulfonate-functionalized Silver Nanoparticles with Virucidal Activity against SARS-CoV-2
Textile Coated with Mercaptoethane Sulfonate-functionalized Silver Nanoparticles with Virucidal Activity against SARS-CoV-2 Open
Recent SARS-CoV-2 pandemic emphasized the need for broad-spectrum intervention before virus-specific vaccination and antiviral drugs are readily available.One of such intervention is blocking of a common step in the virus life cycle such a…
View article: Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors Open
The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in the current medicinal chemistry. Targeting capping machinery could be one of the therapeutic concepts based on a unique mechanism …
View article: Detection of viable SARS-CoV-2 on the hands of hospitalized children with COVID-19
Detection of viable SARS-CoV-2 on the hands of hospitalized children with COVID-19 Open
View article: Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors
Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors Open
View article: Rational design of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors
Rational design of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors Open
The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in current medicinal chemistry. Targeting capping machinery could be one of therapeutic concepts based on a unique mechanism of actio…
View article: Front Cover: Light‐Driven Catalyst‐Free Access to Phthalazines: Entry to Antiviral Model Drugs by Merging Domino Reactions (Eur. J. Org. Chem. 5/2023)
Front Cover: Light‐Driven Catalyst‐Free Access to Phthalazines: Entry to Antiviral Model Drugs by Merging Domino Reactions (Eur. J. Org. Chem. 5/2023) Open
The Front Cover shows a light-induced enolization of o-methyl benzophenones/Diels–Alder reaction, combined with deprotection/aromatization steps in one pot toward new antiviral phthalazines. The Temple of Jupiter in the background is a col…
View article: HIV–1 infection reduces NAD capping of host cell snRNA and snoRNA
HIV–1 infection reduces NAD capping of host cell snRNA and snoRNA Open
Nicotinamide adenine dinucleotide (NAD) is a critical component of the cellular metabolism and also serves as an alternative 5′ cap on various RNAs. However, the function of the NAD RNA cap is still under investigation. We studied NAD capp…
View article: Synthesis and Anticancer and Antiviral Activities of C-2′-Branched Arabinonucleosides
Synthesis and Anticancer and Antiviral Activities of C-2′-Branched Arabinonucleosides Open
d-Arabinofuranosyl-pyrimidine and -purine nucleoside analogues containing alkylthio-, acetylthio- or 1-thiosugar substituents at the C2’ position were prepared from the corresponding 3’,5’-O-silylene acetal-protected nucleoside 2’-exomethy…