Jan Willem Cohen Tervaert
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View article: Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS Open
Long COVID (LC) manifests with sex-specific differences, particularly in those with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study reveals that female LC patients (LCF) with ME/CFS show a shift toward myelopoiesis, …
View article: Severe fatigue is associated with diminished lung function and elevated Galectin-9 levels in early systemic sclerosis
Severe fatigue is associated with diminished lung function and elevated Galectin-9 levels in early systemic sclerosis Open
Introduction Symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently affect patients with rheumatic diseases, but little is known about their frequency and disease manifestations, particularly in systemic…
View article: T-cell immunity in the experimental autoimmune vasculitis rat model
T-cell immunity in the experimental autoimmune vasculitis rat model Open
View article: Thirsty Eyes: A Look at Dry Eyes in Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA; Shoenfeld’s Syndrome)
Thirsty Eyes: A Look at Dry Eyes in Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA; Shoenfeld’s Syndrome) Open
Objectives Many patients with autoimmune syndrome induced by adjuvants (ASIA) due to silicone breast implants complain of dry eyes, which may be due to impaired tear production or increased tear evaporation. The clinical differences betwee…
View article: Metabolic Stress Remodeling: Insights into the Role(s) of FOXO1 in Promoting Cancer-Like Changes in Systemic Sclerosis (SSc)
Metabolic Stress Remodeling: Insights into the Role(s) of FOXO1 in Promoting Cancer-Like Changes in Systemic Sclerosis (SSc) Open
Objectives Systemic sclerosis (SSc) is a life-threatening autoimmune disease with limited treatment options. Autologous stem cell transplantation (ASCT) is the only disease-modifying therapy in SSc; however, its effects on fibroblasts are …
View article: Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study
Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study Open
View article: Comparison of [18F]fluorodeoxyglucose and [68Ga]Gallium DOTA-TATE in patients with active giant cell arteritis
Comparison of [18F]fluorodeoxyglucose and [68Ga]Gallium DOTA-TATE in patients with active giant cell arteritis Open
In this pilot study of patients with active GCA, the arterial uptake of [68Ga]Ga-HA-DOTA-TATE was lower and less conspicuous compared to [18F]FDG. While further evaluation in larger cohorts is needed, a clear advantag…
View article: Mepolizumab vs Benralizumab for Eosinophilic Granulomatosis with Polyangiitis (EGPA): a European comparative study Short running title: Mepolizumab versus Benralizumab for EGPA
Mepolizumab vs Benralizumab for Eosinophilic Granulomatosis with Polyangiitis (EGPA): a European comparative study Short running title: Mepolizumab versus Benralizumab for EGPA Open
View article: Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome
Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome Open
A substantial number of patients recovering from acute SARS-CoV-2 infection present serious lingering symptoms, often referred to as long COVID (LC). However, a subset of these patients exhibits the most debilitating symptoms characterized…
View article: The case for a national breast implant registry in Canada
The case for a national breast implant registry in Canada Open
SummaryThe House of Commons Standing Committee on Health proposed in 2022 to start a national registry for breast implants. Why, and what requirements are needed, will be outlined. Breast implant products are not always in compliance with …
View article: Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome
Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome Open
Introduction A group of SARS-CoV-2 infected individuals present lingering symptoms, defined as long COVID (LC), that may last months or years post the onset of acute disease. A portion of LC patients have symptoms similar to myalgic enceph…
View article: Understanding COVID-19 vaccine hesitancy in vasculitis patients
Understanding COVID-19 vaccine hesitancy in vasculitis patients Open
Objective To identify the factors that impact COVID-19 vaccine decision-making in vaccine-hesitant vasculitis patients, and compare their perceptions with other rheumatology patients, given existence of data suggesting rheumatology patient…
View article: Incidence and prevalence, and medication use among adults living with dermatomyositis: an Alberta, Canada population-based cohort study
Incidence and prevalence, and medication use among adults living with dermatomyositis: an Alberta, Canada population-based cohort study Open
View article: The cancer-associated glycan polysialic acid is dysregulated in systemic sclerosis and is associated with fibrosis
The cancer-associated glycan polysialic acid is dysregulated in systemic sclerosis and is associated with fibrosis Open
Polysia is more abundant in the skin and sera from patients with SSc and correlates with the degree of skin fibrosis. The aberrant expression of polySia highlights its potential use as a biomarker in patients with progressive forms of SSc.…
View article: Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis: a European retrospective study
Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis: a European retrospective study Open
View article: Evidence of a Novel Mitochondrial Signature in Systemic Sclerosis Patients with Chronic Fatigue Syndrome
Evidence of a Novel Mitochondrial Signature in Systemic Sclerosis Patients with Chronic Fatigue Syndrome Open
Symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are common in rheumatic diseases, but no studies report the frequency of these in early systemic sclerosis. There are no known biomarkers that can distinguish between …
View article: Methods of Assessing Nailfold Capillaroscopy Compared to Video Capillaroscopy in Patients with Systemic Sclerosis—A Critical Review of the Literature
Methods of Assessing Nailfold Capillaroscopy Compared to Video Capillaroscopy in Patients with Systemic Sclerosis—A Critical Review of the Literature Open
Introduction: Nailfolds of patients with systemic sclerosis (SSc) provide an opportunity to directly visualize microvascular remodeling in SSc. Nailfold video capillaroscopy (NVC) remains the gold standard for assessing nailfold capillaros…
View article: AB0796 CANVASC CONSENSUS RECOMMENDATIONS FOR THE USE OF AVACOPAN IN ANTINEUTROPHIL CYTOPLASM ANTIBODY-ASSOCIATED VASCULITIS: 2022 ADDENDUM
AB0796 CANVASC CONSENSUS RECOMMENDATIONS FOR THE USE OF AVACOPAN IN ANTINEUTROPHIL CYTOPLASM ANTIBODY-ASSOCIATED VASCULITIS: 2022 ADDENDUM Open
Background In 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV). Since then, clinical data on the c…
View article: Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis Open
View article: For Your Eyes Only: 007 Tips for the Management of Cardiovascular Risk Factors in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
For Your Eyes Only: 007 Tips for the Management of Cardiovascular Risk Factors in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Open
Premature atherosclerosis has been observed during the course of different systemic inflammatory diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus, and antineutrophil cytoplasmic antibody (ANCA)-associated vasculiti…
View article: Vaccine hesitancy is not increased in patients with ASIA (autoimmune/inflammatory syndrome induced by adjuvants) when compared to patients with vasculitis
Vaccine hesitancy is not increased in patients with ASIA (autoimmune/inflammatory syndrome induced by adjuvants) when compared to patients with vasculitis Open
View article: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia: PR3-versus MPO-ANCA-associated vasculitis, an exploratory cross-sectional study
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia: PR3-versus MPO-ANCA-associated vasculitis, an exploratory cross-sectional study Open
This manuscript was funded by the Dutch Kidney Foundation (17PhD01).
View article: CanVasc consensus recommendations for the use of avacopan in antineutrophil cytoplasm antibody-associated vasculitis: 2022 addendum
CanVasc consensus recommendations for the use of avacopan in antineutrophil cytoplasm antibody-associated vasculitis: 2022 addendum Open
Objective In 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of ANCA-associated vasculitides (AAV). The current addendum provides further recommendations regarding the use…
View article: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023 Open
In 2011, a syndrome entitled ASIA (Autoimmune/inflammatory Syndrome Induced by Adjuvants; Shoenfeld's syndrome) was first described. ASIA aimed to organize under a single umbrella, the existing evidence regarding certain environmental fact…
View article: A case series of dermatomyositis following SARS-CoV-2 vaccination
A case series of dermatomyositis following SARS-CoV-2 vaccination Open
Background/Objective The most significant adverse events following SARS-CoV-2 vaccination are myocarditis and pericarditis. Myositis and dermatomyositis have been reported following SARS-CoV-2 infection, but vaccine-induced dermatomyositis…
View article: Fatigue in ANCA-associated vasculitis (AAV) and systemic sclerosis (SSc): similarities with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A critical review of the literature
Fatigue in ANCA-associated vasculitis (AAV) and systemic sclerosis (SSc): similarities with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A critical review of the literature Open
Persistent fatigue is a prominent feature in SARDs and may not be associated with components commonly associated with disease activity and/or progression. Immune and metabolic commonalities exist between ME/CFS, SSc, and PSVs - suggesting …
View article: Response to letter to the editor: Bradford Hill and breast implant illness: evidence for a causal association with breast implants
Response to letter to the editor: Bradford Hill and breast implant illness: evidence for a causal association with breast implants Open
KEYWORDS: Breast implant illnesscausationBradford Hill criteriafibromyalgiachronic fatigue syndrome/myalgic encephalomyelitis
View article: A Novel Mitochondrial Signature Defines Chronic Fatigue Syndrome in Patients with Early Systemic Sclerosis
A Novel Mitochondrial Signature Defines Chronic Fatigue Syndrome in Patients with Early Systemic Sclerosis Open
View article: Nailfold Capillaroscopy Abnormalities Correlate With Disease Activity in Adult Dermatomyositis
Nailfold Capillaroscopy Abnormalities Correlate With Disease Activity in Adult Dermatomyositis Open
Objectives: The aim of this study was to determine the relationship between disease activity in adult patients with dermatomyositis (DM) and other biomarkers of disease activity such as C-reactive protein creatinine kinase and nailfold vid…
View article: Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study
Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study Open
Objective Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported studies, successfu…