Jana Ihlow
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View article: Therapy-induced senescence reprograms non-M3 AML into a drug-exploitable APL-like state
Therapy-induced senescence reprograms non-M3 AML into a drug-exploitable APL-like state Open
Cellular senescence is a dynamic cancer cell condition with both tumor-suppressive and relapse-promoting features. While terminating cell proliferation, it may sustain disease persistence through its senescence-associated secretory phenoty…
View article: Macrophage Activation-Like Syndrome in critically ill patients with sepsis: high risk patients with high mortality
Macrophage Activation-Like Syndrome in critically ill patients with sepsis: high risk patients with high mortality Open
MALS increased in-hospital mortality in sepsis patients. Our results underscore the urgent need for targeted research and therapeutic strategies. While promising insights into immune modulation have emerged, further studies are essential t…
View article: Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma
Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma Open
Oral squamous cell carcinoma (OSCC) is highly heterogeneous and metastatic, and the mechanisms driving OSCC development, progression, and metastasis remain elusive. Here, we performed single-cell RNA sequencing on 231,442 cells obtained fr…
View article: Characterizing uveal melanoma patients with peritoneal metastases: A retrospective single-center analysis
Characterizing uveal melanoma patients with peritoneal metastases: A retrospective single-center analysis Open
PM in mUM patients is rare and in contrast to other extra-abdominal tumors does not worsen prognosis. Prognosis is greatly influenced by the metastatic pattern, which is determined by tumor biology, as evidenced by its correlation with gen…
View article: Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling
Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling Open
The study was funded by intramural resources of the Charité - Universitätsmedizin Berlin and the Berlin Institute of Health.
View article: DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites
DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites Open
Background We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy ( PAAD-iCCA-Classifie…
View article: Multi-Drug Pharmacotyping improves Therapy Prediction in Pancreatic Cancer Organoids
Multi-Drug Pharmacotyping improves Therapy Prediction in Pancreatic Cancer Organoids Open
Patient-Derived Organoids (PDOs) represent a promising technology for therapy prediction in pancreatic cancer, with the potential of enhancing treatment outcomes and allowing more effective, personalized treatment choices. However, classif…
View article: Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy
Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy Open
Therapy-related acute myeloid leukemia (t-AML) often exhibits adverse (genetic) features. There is ongoing discussion on the impact of t-AML on long-term outcome in AML. Therefore, we retrospectively analyzed clinical and biological charac…
View article: Next-Generation-Sequencing of the Human B-Cell Receptor Improves Detection and Diagnosis and Enhances Disease Monitoring in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Next-Generation-Sequencing of the Human B-Cell Receptor Improves Detection and Diagnosis and Enhances Disease Monitoring in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Open
Mucosa-associated lymphoid tissue (MALT) lymphomas are slow-growing B-cell lymphomas mainly diagnosed in the stomach and termed gastric MALT lymphoma (G-MALT). Despite histological evaluation, immunostaining, and additional B-cell clonalit…
View article: A diagnostic challenge of KIT p.V559D and BRAF p.G469A mutations in a paragastric mass
A diagnostic challenge of KIT p.V559D and BRAF p.G469A mutations in a paragastric mass Open
A patient with gastrointestinal stroma tumor (GIST) and KIT p.V559D and BRAF p.G469A alterations was referred to our institutional molecular tumor board (MTB) to discuss therapeutic implications. The patient had been diagnosed with B-cell …
View article: Intrahepatic Mass-Forming Cholangiocarcinoma: Is There Additional Prognostic Value in Using Gd-EOB Enhanced MRI?
Intrahepatic Mass-Forming Cholangiocarcinoma: Is There Additional Prognostic Value in Using Gd-EOB Enhanced MRI? Open
Objective: To investigate the prognostic value of enhancement patterns of intrahepatic mass-forming cholangiocarcinomas (IMCCs) during the hepatobiliary phase (HBP) in gadoxetic acid (Gd-EOB)-enhanced MRI. Methods: We retrospectively ident…
View article: Value of hemophagocytosis in the diagnosis of hemophagocytic lymphohistiocytosis in critically ill patients
Value of hemophagocytosis in the diagnosis of hemophagocytic lymphohistiocytosis in critically ill patients Open
Background Ferritin is an established biomarker in the diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH), which is diagnosed by the HLH‐2004 criteria. Among these criteria, detection of hemophagocytosis through invasive proce…
View article: Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19 Open
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the mechanisms that contribute to this remain unclear. Here we p…
View article: Prevalence of TERT Promoter Mutations in Orbital Solitary Fibrous Tumors
Prevalence of TERT Promoter Mutations in Orbital Solitary Fibrous Tumors Open
The orbital manifestation of a solitary fibrous tumor (SFT) is exceptionally rare and poses specific challenges in diagnosis and treatment. Its rather exceptional behavior among all SFTs comprises a high tendency towards local recurrence, …
View article: Renal Extramedullary Hematopoiesis in Mast Cell Leukemia with Bone Marrow Fibrosis
Renal Extramedullary Hematopoiesis in Mast Cell Leukemia with Bone Marrow Fibrosis Open
Systemic mastocytosis is defined by the clonal proliferation of abnormal mast cells. The clinical course can range from indolent forms with normal life expectancy to advanced mast cell leukemia with dismal prognosis. An association with ot…
View article: Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients—A Single Center Analysis of 2323 Patients within the Last Decade
Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients—A Single Center Analysis of 2323 Patients within the Last Decade Open
In addition to being risk factors for pancreatic cancer, parameters such as smoking, diabetes, or obesity might also act as potential prognostic factors for the survival of patients initially diagnosed with pancreatic cancer. By implementi…
View article: Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5th edition of the World Health Organization classification
Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5th edition of the World Health Organization classification Open
Objectives To investigate the value of gadoxetic acid (Gd-EOB)–enhanced magnetic resonance imaging (MRI) for noninvasive subtype differentiation of HCCs according to the 5 th edition of the WHO Classification of Digestive System Tumors in …
View article: Inflammation-Based Prognostic Scores in Pancreatic Cancer Patients—A Single-Center Analysis of 1294 Patients within the Last Decade
Inflammation-Based Prognostic Scores in Pancreatic Cancer Patients—A Single-Center Analysis of 1294 Patients within the Last Decade Open
Inflammatory properties are known to promote tumor progression leading to an impaired median overall survival (mOS). Various small studies have focused on a wide range of inflammation-based prognostic indicators. By using sufficient data f…
View article: Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19 Open
Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In this study, we combine advanced imaging and spatial transcriptomics to…
View article: The central nervous system’s proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2
The central nervous system’s proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2 Open
In COVID-19 neurological alterations are noticed during the systemic viral infection. Various pathophysiological mechanisms on the central nervous system (CNS) have been suggested in the past two years, including the viral neurotropism hyp…
View article: The central nervous system's proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2
The central nervous system's proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2 Open
Data set including image files of histological stainings, immunohistochemistry, MELC, and spatial transcriptomics associated with the study mentioned above.
View article: The central nervous system's proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2
The central nervous system's proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2 Open
Data set including image files of histological stainings, immunohistochemistry, MELC, and spatial transcriptomics associated with the study mentioned above.
View article: The central nervous system's proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2
The central nervous system's proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2 Open
Data set including image files of histological stainings, immunohistochemistry, MELC, and spatial transcriptomics associated with the study mentioned above.
View article: Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia Open
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death in…
View article: Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer
Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer Open
RGS2 regulates G-protein signaling by accelerating hydrolysis of GTP and has been identified as a potentially druggable target in carcinomas. Since the prognosis of patients with high-grade serous ovarian carcinoma (HGSOC) remains utterly …