Jana Klánová
YOU?
Author Swipe
View article: Functional Impact Score of Mitochondrial Variants and Its Relationship With Functional Connectivity of the Brain: Potential Origins of Premature Aging in Young Adulthood
Functional Impact Score of Mitochondrial Variants and Its Relationship With Functional Connectivity of the Brain: Potential Origins of Premature Aging in Young Adulthood Open
Alterations in mitochondrial DNA (mtDNA) have been associated with worse cognitive abilities in older adults and premature epigenetic aging in young adulthood. However, it is not clear how mitochondrial dysfunction affects brain function i…
View article: Adverse childhood experiences and adolescent externalizing and internalizing problems in the ELSPAC-CZ cohort
Adverse childhood experiences and adolescent externalizing and internalizing problems in the ELSPAC-CZ cohort Open
Background Exposure to adverse childhood experiences (ACEs) has been linked to mental health difficulties later in life. However, much of the existing research relies on cross-sectional designs and retrospectively reported ACEs, which are …
View article: The impact of environmental exposures on DNA methylation in the EXPANSE project
The impact of environmental exposures on DNA methylation in the EXPANSE project Open
This work was supported by the EXPANSE project, funded by the European Union's Horizon 2020 research and innovation programme under grant agreement No. 874627.
View article: The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease Open
The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. END…
View article: Temporal patterns of bisphenol exposure in the Czech population within the framework of regulatory measures
Temporal patterns of bisphenol exposure in the Czech population within the framework of regulatory measures Open
Background Bisphenol A (BPA) and its replacements bisphenols S and F (BPS and BPF) are synthetic compounds commonly used in plastics and epoxy resins. Their endocrine-disrupting properties are of concern due to the broad use of plastic mat…
View article: Weight Trajectories Among Youths Following Residential Relocation
Weight Trajectories Among Youths Following Residential Relocation Open
Importance Overweight and obesity affect millions of children and adolescents worldwide, and its prevalence is increasing. Objective To investigate the associations of changes in the surrounding residential environment following relocation…
View article: Maternal Antenatal Depression and Deviations From Normative Brain Development in Offspring
Maternal Antenatal Depression and Deviations From Normative Brain Development in Offspring Open
Given the importance of the thalamus in the pathogenesis of major depressive disorder and the critical role of the nucleus accumbens in reward and motivation, the altered development of these subcortical structures may contribute to a high…
View article: Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population
Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population Open
Background Temporal trends of chemicals in the population are key to identifying changing sources of chemicals and determining the effectiveness of various legislative measures. Objective The present study focused on time comparisons to ex…
View article: Galaxy QCxMS for straightforward semi-empirical quantum mechanical EI-MS prediction
Galaxy QCxMS for straightforward semi-empirical quantum mechanical EI-MS prediction Open
High-performance computing (HPC) environments are crucial for computational research, including quantum chemistry (QC), but pose challenges for non-expert users. Researchers with limited computational knowledge struggle to utilise domain-s…
View article: Galaxy QCxMS for Straightforward Semi-Empirical Quantum Mechanical EI-MS Prediction
Galaxy QCxMS for Straightforward Semi-Empirical Quantum Mechanical EI-MS Prediction Open
High-performance computing (HPC) environments are crucial for computational research, including quantum chemistry (QC), but pose challenges for non-expert users. Researchers with limited computational knowledge struggle to utilise domain-s…
View article: Viable bacterial communities in freshly pumped human milk and their changes during cold storage conditions
Viable bacterial communities in freshly pumped human milk and their changes during cold storage conditions Open
Background Human milk harbors diverse bacterial communities that contribute to infant health. Although pumping and storing milk is a common practice, the viable bacterial composition of pumped milk and the impact of storage practice on the…
View article: Self-Rated Health of the Middle-Aged Population and its Determinants
Self-Rated Health of the Middle-Aged Population and its Determinants Open
Background The results of epidemiological studies indicate associations between poor self-rated health (SRH) and many factors like age, education level, income, physical activity etc. The aim of this study was to analyse the associations b…
View article: External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project
External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project Open
This study was funded by the European Union's Horizon 2020 research and innovation program under agreement No 874627 (EXPANSE).
View article: Integrating exposomics into biomedicine
Integrating exposomics into biomedicine Open
Assessing a full range of environmental exposures will improve human health
View article: Determination of Thyroid Hormones and 11 Metabolites in the Human Serum Using a Simple Derivatization Strategy and Analysis by Isotope-Dilution Liquid Chromatography Tandem Mass Spectrometry
Determination of Thyroid Hormones and 11 Metabolites in the Human Serum Using a Simple Derivatization Strategy and Analysis by Isotope-Dilution Liquid Chromatography Tandem Mass Spectrometry Open
Many analytical methods for thyroid hormone (TH) determination lack sensitivity and/or specificity. The thyroid hormone metabolites (THMs) are usually not measured at all. This study describes the development of sensitive high-throughput a…
View article: Dual LC column characterization for mass spectrometry-based small molecule profiling of human plasma and serum
Dual LC column characterization for mass spectrometry-based small molecule profiling of human plasma and serum Open
As proof of concept, 129 metabolites were annotated in pooled human serum and plasma by matching standard or predicted RT on one or both columns. The RT models and MS2 spectra of standards are openly available, facilitating uptake of this …
View article: Polycyclic aromatic hydrocarbon (PAH) exposure among European adults: Evidence from the HBM4EU aligned studies
Polycyclic aromatic hydrocarbon (PAH) exposure among European adults: Evidence from the HBM4EU aligned studies Open
Polycyclic aromatic hydrocarbons (PAHs) are persistent environmental pollutants with well-documented associations to adverse health effects, posing significant public health challenges across Europe. Human exposure to 13 urinary PAH metabo…
View article: Advancing Data Infrastructure for Chemical Risk Assessment and Exposome Research: The GENASIS Platform in the Context of FAIR Principles
Advancing Data Infrastructure for Chemical Risk Assessment and Exposome Research: The GENASIS Platform in the Context of FAIR Principles Open
Excellence in exposome research and chemical risk assessment (CRA) relies on robust capacities, innovative technologies, and skilled human resources. Research infrastructures are vital in providing access to these resources and driving inn…
View article: Workflow4Metabolomics (W4M): A User‐Friendly Metabolomics Platform for Analysis of Mass Spectrometry and Nuclear Magnetic Resonance Data
Workflow4Metabolomics (W4M): A User‐Friendly Metabolomics Platform for Analysis of Mass Spectrometry and Nuclear Magnetic Resonance Data Open
Various spectrometric methods can be used to conduct metabolomics studies. Nuclear magnetic resonance (NMR) or mass spectrometry (MS) coupled with separation methods, such as liquid or gas chromatography (LC and GC, respectively), are the …
View article: Automated Sequential Derivatization for Gas Chromatography-[Orbitrap] Mass Spectrometry-based Metabolite Profiling of Human Blood-based Samples
Automated Sequential Derivatization for Gas Chromatography-[Orbitrap] Mass Spectrometry-based Metabolite Profiling of Human Blood-based Samples Open
Many small molecules require derivatization to increase their volatility and to be amenable to gas chromatographic (GC) separation. Derivatization is usually time-consuming, and typical batch-wise procedures increase sample variability. Se…
View article: The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease Open
The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. END…
View article: Resistome in the indoor dust samples from workplaces and households: a pilot study
Resistome in the indoor dust samples from workplaces and households: a pilot study Open
The antibiotic resistance genes (ARGs) limit the susceptibility of bacteria to antimicrobials, representing a problem of high importance. Current research on the presence of ARGs in microorganisms focuses mainly on humans, livestock, hospi…
View article: Early life social conditions and adverse experiences are associated with childhood <scp>BMI</scp> and perceived overeating
Early life social conditions and adverse experiences are associated with childhood <span>BMI</span> and perceived overeating Open
Summary Background Early life socioeconomic disadvantage and adverse experiences may lead to overeating, which is in turn associated with increased body mass index (BMI). However, recent evidence indicated that the association between chil…
View article: Quantum Chemistry-Based Prediction of Electron Ionization Mass Spectra for Environmental Chemicals
Quantum Chemistry-Based Prediction of Electron Ionization Mass Spectra for Environmental Chemicals Open
There is a lack of experimental electron ionization high-resolution mass spectra available to assist compound identification. The in silico generation of mass spectra by quantum chemistry can aid annotation workflows, in particular to supp…
View article: Viable bacterial communities in freshly pumped human milk and their changes during cold storage conditions
Viable bacterial communities in freshly pumped human milk and their changes during cold storage conditions Open
Background Human milk harbors diverse bacterial communities that contribute to infant health. Although pumping and storing milk is a common practice, the viable bacterial composition of pumped milk and the impact of storage practice on the…