Explanipedia

Large‐scale DNA methylation profiling of urological cancers identifies shared and cancer‐specific methylation signatures, and reveals differentially activated pathways for therapeutic targeting Open

Vera Constâncio, João Lobo, Antonio Gómez, João Carvalho, Isa Carneiro , et al. · 2025

Gestão dos resíduos sólidos: uma abordagem das práticas do município de Cáceres/MT com o descarte dos resíduos sólidos urbanos Open

Raul Angel Carlos Olivera, João Carvalho, J. Fernando Silva, Cesar David Mendo, Cristina Teodoro de Melo Mendo , et al. · 2025

O tema, resíduos sólidos, tem sido um dos principais assuntos discutidos pela sociedade atual. O município de Cáceres/MT tem como desafio a gestão de resíduos sólidos, tendo em vista a cobrança por parte da sociedade civil e dos órgãos não…

Distribuição e utilização de aparelhos de Raios-x odontológico no Brasil: uma análise da produção ambulatorial Open

Yasmin Caldas de Macêdo Abrantes Rodrigues de Oliveira, Marcelo de Lima, Damião Romão Dias da Silva, T Lima, Basílio Rodrigues Vieira , et al. · 2025

Objetivo: Explanar a disponibilidade de aparelhos de Raios-x odontológico e sua produção ambulatorial no Brasil. Métodos: realizou-se um estudo ecológico, utilizando dados secundários oriundos de bases eletrônicas disponibilizadas pelo Min…

Assessing the Impact of Old Age on Upper Tract Urothelial Carcinoma: A Retrospective Analysis from a Portuguese Tertiary Center Open

F. Portugal Gaspar, Filipe Lopes, Jorge Correia, João Carvalho, Rui Freitas , et al. · 2025

Introduction: Upper tract urothelial carcinoma is an infrequent but aggressive disease. Radical nephroureterectomy is the standard of care for nonmetastatic tumors. The potential implications of old age in the management of upper tract uro…

Characterization of the Population, Treatment Patterns, and Outcomes of Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor Mutation (EGFRm): A Retrospective Cohort Study from IPO Porto Open

Ana Rodrigues, Marta Pina, Rita Calisto, Pedro Leite‐Silva, Pedro Medeiros , et al. · 2025

Most patients with non-small-cell lung cancer (NSCLC) present with advanced/metastatic disease at diagnosis, and molecular profiling is critical in guiding treatment decisions. This retrospective cohort study aimed to characterize EGFR mut…

Management of infusion-related reactions in cancer therapy: strategies and challenges Open

Ana Barroso, F. Estevinho, Venceslau Hespanhol, E. Teixeira, João Carvalho , et al. · 2024

Quantitative Descriptive Sensory Profile and Volatile Analysis of Chocolates Produced from Cocoa from Bahia with Potential for Fine Cocoa Open

Joelaine de Jesus Santana, Manuela B. Nascimento, Taiana Varela Ferreira, João Carvalho, Lino O. Santos , et al. · 2024

Renal cell carcinoma with vena cava thrombus management and results in a tertiary center Open

G. Faria Costa, Rui Freitas, Maria Ana Alzamora, Isaac Braga, S.M.M. Magalhães , et al. · 2023

Alpha-1 antitrypsin deficiency in Madeira Island: The first null variant and the contribution of deficient genotypes Open

Ana Sara Gonçalves, João Carvalho, Cláudia S. Sousa, Susana Seixas, Vítor Teixeira · 2023

OncoUroMiR: Circulating miRNAs for Detection and Discrimination of the Main Urological Cancers Using a ddPCR-Based Approach Open

José Pedro Sequeira, Daniela Barros‐Silva, Patrícia Ferreira-Torre, Sofia Salta, Isaac Braga , et al. · 2023

The three most common genitourinary malignancies (prostate/kidney/bladder cancers) constitute a substantial proportion of all cancer cases, mainly in the elderly population. Early detection is key to maximizing the patients’ survival, but …

Validation and Application of Predictive Models for Inadequate Bowel Preparation in Colonoscopies in a Tertiary Hospital Population Open

Edgar Afecto, Ana Ponte, Sónia Fernandes, Catarina Gomes, João Correia , et al. · 2021

Background: Bowel preparation is a major quality criterion for colonoscopies. Models developed to identify patients with inadequate preparation have not been validated in external cohorts. We aim to validate these models and determine thei…

Colorectal Screening Program in Northern Portugal: First Findings Open

Hugo J. Monteiro, Fernando Tavares, João Reis, Gustavo Fernandes Ferreira, M. José Campos , et al. · 2021

Introduction: In Portugal, a colorectal cancer screening program based on faecal immunochemical test followed by colonoscopy was shown to be cost-effective for individuals between 50 and 74 years old. We report the first findings of the im…

Spontaneous Resolution of Enterocutaneous Fistula After Disseminated Tuberculosis Treatment in a Patient With Crohn’s Disease: Challenges in Biologic Therapy Open

João Carlos Silva, Adélia Rodrigues, João Carvalho · 2019

Circulating MicroRNAs as Biomarkers for Prostate Cancer Detection and Metastasis Development Prediction Open

David Bidarra, Vera Constâncio, Daniela Barros‐Silva, João Carvalho, Catarina Moreira-Barbosa , et al. · 2019

Prostate Cancer (PCa) overdiagnosis and overtreatment, as a consequence of the limited specificity of current detection and prognostication methods, remains a major challenge in clinical practice. Therefore, development and validation of n…

A Case of Gastric Ischemia: Management and Prognosis Open

João Carlos Silva, Adélia Rodrigues, Ana Ponte, Ana Paula Silva, João Carvalho · 2019

Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype Open

Soraia Silva, Sara Monteiro‐Reis, Daniela Barros‐Silva, João Carvalho, Inês Graça , et al. · 2019

P555 Deep remission and mucosal healing in IBD patients under immunosuppression with azathioprine and 6-mercaptopurine Open

João Carlos Silva, A P Silva, Adélia Rodrigues, Carlos Fernandes, Ana Ponte , et al. · 2019

Mucosal healing and deep remission (DR) are therapeutic targets in inflammatory bowel disease (IBD). We aimed to characterise DR in patients with Crohn's Disease (CD) and ulcerative colitis (UC) under monotherapy with immunomodulators. Out…

Underwater endoscopic mucosal resection of a laterally spreading tumor overlying a previous endoscopic carbon tattoo Open

Jaime Rodrigues, Rolando Pinho, Mafalda Sousa, João Carlos Silva, Catarina Gomes , et al. · 2018

A 53-year-old man with no relevant past medical history was referred to our department for resection of a laterally spreading tumor (LST) on the descending colon, which had been tattooed previously.

A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 Open

João Carvalho, Céline S. Gonçalves, Inês Graça, David Bidarra, Eva Pereira-Silva , et al. · 2018

High immunoexpression of Ki67, EZH2, and SMYD3 in diagnostic prostate biopsies independently predicts outcome in patients with prostate cancer Open

João Lobo, Adriana R. Rodrigues, Luís Antunes, Inês Graça, João Carvalho , et al. · 2017

Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer Open

João Carvalho, Inês Graça, Antonio Gómez, Jorge Oliveira, Rui Henrique , et al. · 2017

Altogether, these data demonstrate that miR-130b~301b cluster overexpression might effectively induce PCa cell growth arrest through epigenetic regulation of proliferation-blocking genes and activation of cellular senescence.

MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors Open

Jorge Torres-Ferreira, João Carvalho, Antonio Gómez, Francisco Menezes, Rui Freitas , et al. · 2017

MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma Open

Nuno Padrão, Sara Monteiro‐Reis, Jorge Torres-Ferreira, Luís Antunes, Luís Leça , et al. · 2017

This panel of miRNAs promoter methylation accurately detects UC in urine, comparing well with other promising epigenetic-based biomarkers. This may constitute the basis for a non-invasive assay to detect UC.

Hypersensitivity to azathioprine in a patient with Crohns disease: a case report Open

Mafalda Sousa, Luísa Proença, João Carvalho · 2017

Azathioprine (AZA) is commonly used in inflammatory bowel disease and many other medical diseases. The most common adverse events of AZA include gastrointestinal effects, hepatotoxicity, myelotoxicity and pancreatitis.

Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer Open

Diogo Almeida-Rios, Inês Graça, Filipa Quintela Vieira, João Carvalho, Eva Pereira-Silva , et al. · 2016

Prostate cancer (PCa) is a major cause of morbidity and mortality. Until now the specific role of histone methyltransferases (HMTs) deregulated expression/activity in PCa is poorly understood. Herein we aimed to uncover the potential oncog…

MicroRNA-375 plays a dual role in prostate carcinogenesis Open

Pedro Costa‐Pinheiro, João Carvalho, Filipa Quintela Vieira, Jorge Torres-Ferreira, Jorge Oliveira , et al. · 2015

A Large Gastric Inflammatory Fibroid Polyp Open

Teresa Pinto-Pais, Sónia Fernandes, Luísa Proença, Carlos Fernandes, Iolanda Ribeiro , et al. · 2015

Inflammatory fibroid polyp (IFP) is an unusual benign gastrointestinal subepithelial tumor (SET). The endosonographic (EUS) features of IFPs were sporadically reported on imaging tips or small case series study. However, the differential d…

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