Janaka Senarathna
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View article: Proof-of-Concept Monitoring of Cerebral Hemodynamics in a Porcine Extracorporeal Cardiopulmonary Resuscitation Model Using Dual-Mode Laser Speckle and Intrinsic Optical Imaging
Proof-of-Concept Monitoring of Cerebral Hemodynamics in a Porcine Extracorporeal Cardiopulmonary Resuscitation Model Using Dual-Mode Laser Speckle and Intrinsic Optical Imaging Open
Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory cardiac arrest, yet neurologic outcome is often limited by acute brain injury (ABI) secondary to disrupted cerebrovascular autoregulation (CVAR). We es…
View article: Cryptography in Secure Cloud Computing
Cryptography in Secure Cloud Computing Open
Cloud computing offers cost efficiency and scalability but introduces significant security concerns related to data control. Cryptography addresses these concerns by ensuring data confidentiality, integrity, authenticity, and availability …
View article: State-of-the-art techniques for imaging the vascular microenvironment in craniofacial bone tissue engineering applications
State-of-the-art techniques for imaging the vascular microenvironment in craniofacial bone tissue engineering applications Open
Vascularization is a crucial step during musculoskeletal tissue regeneration via bioengineered constructs or grafts. Functional vasculature provides oxygen and nutrients to the graft microenvironment, facilitates wound healing, enhances gr…
View article: Visualizing the Microcirculation
Visualizing the Microcirculation Open
Over the last century, scientific discoveries have revealed the critical role of the microcirculation in maintaining homeostasis and the etiology of diseases ranging from cancer to COVID-19. These advances have coincided with and even been…
View article: In vivo phenotyping of the microvasculature in necrotizing enterocolitis with multicontrast optical imaging
In vivo phenotyping of the microvasculature in necrotizing enterocolitis with multicontrast optical imaging Open
Objective Necrotizing enterocolitis (NEC) is the most prevalent gastrointestinal emergency in premature infants and is characterized by a dysfunctional gut microcirculation. Therefore, there is a dire need for in vivo methods to characteri…
View article: Advances in translational imaging of the microcirculation
Advances in translational imaging of the microcirculation Open
The past few decades have seen an explosion in the development and use of methods for imaging the human microcirculation during health and disease. The confluence of innovative imaging technologies, affordable computing power, and economie…
View article: HemoSYS: A Toolkit for Image-based Systems Biology of Tumor Hemodynamics
HemoSYS: A Toolkit for Image-based Systems Biology of Tumor Hemodynamics Open
Abnormal tumor hemodynamics are a critical determinant of a tumor’s microenvironment (TME), and profoundly affect drug delivery, therapeutic efficacy and the emergence of drug and radio-resistance. Since multiple hemodynamic variables can …
View article: Phenotyping the Microvasculature in Critical-Sized Calvarial Defects via Multimodal Optical Imaging
Phenotyping the Microvasculature in Critical-Sized Calvarial Defects via Multimodal Optical Imaging Open
Tissue-engineered scaffolds are a powerful means of healing craniofacial bone defects arising from trauma or disease. Murine models of critical-sized bone defects are especially useful in understanding the role of microenvironmental factor…
View article: Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors
Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors Open
Functional magnetic resonance imaging (fMRI) serves as a critical tool for presurgical mapping of eloquent cortex and changes in neurological function in patients diagnosed with brain tumors. However, the blood-oxygen-level-dependent (BOLD…