Janam J. Dave
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View article: Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics
Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics Open
Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strain enters cells via membrane wounding an…
View article: Mutational Analysis of Human Norovirus VP2 Elucidates Critical Molecular Interactions for Virus Assembly
Mutational Analysis of Human Norovirus VP2 Elucidates Critical Molecular Interactions for Virus Assembly Open
Human noroviruses ( HuNoV s) are the leading cause of viral gastroenteritis with ≥80% of infections caused by the GII genogroup. HuNoVs are non-enveloped, with an icosahedral capsid composed of 90 dimers of the major capsid protein VP1, wh…
View article: BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry
BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry Open
Human norovirus is the leading cause of viral gastroenteritis across all age groups. While there is a need for human norovirus antivirals, therapeutic development has been hindered by a lack of cell culture systems and animal models of inf…
View article: Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics
Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics Open
Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strain enters cells via membrane wounding an…
View article: The CRAC channel inhibitor BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry
The CRAC channel inhibitor BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry Open
Human norovirus is the leading cause of viral gastroenteritis across all age groups. While there is a need for human norovirus antivirals, therapeutic development has been hindered by a lack of cell culture systems and animal models of inf…
View article: Insights into human norovirus cultivation in human intestinal enteroids
Insights into human norovirus cultivation in human intestinal enteroids Open
Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century. This…
View article: Insights into Human Norovirus Cultivation in Human Intestinal Enteroids
Insights into Human Norovirus Cultivation in Human Intestinal Enteroids Open
Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century. This…