Jane A. English
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View article: The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat
The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat Open
The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason…
View article: Non-Invasive Imaging Techniques for Diagnosis of Pelvic Deep Endometriosis and Endometriosis Classification Systems: An International Consensus Statement
Non-Invasive Imaging Techniques for Diagnosis of Pelvic Deep Endometriosis and Endometriosis Classification Systems: An International Consensus Statement Open
View article: Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats
Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats Open
Lifestyle factors, especially exercise, impact the manifestation and progression of psychiatric and neurodegenerative disorders such as depression and Alzheimer’s disease, mediated by changes in hippocampal neuroplasticity. The beneficial …
View article: The 'middle-aging' brain
The 'middle-aging' brain Open
View article: Proteomic analysis investigating kidney transplantation outcomes- a scoping review
Proteomic analysis investigating kidney transplantation outcomes- a scoping review Open
View article: Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis Open
Alzheimer’s disease is a complex neurodegenerative disorder leading to a decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor in Alzheimer’s disease by sho…
View article: Evaluation of hydrophilic interaction chromatography versus reversed-phase chromatography for fast aqueous species distribution analysis of Nickel(II)-Histidine complex species
Evaluation of hydrophilic interaction chromatography versus reversed-phase chromatography for fast aqueous species distribution analysis of Nickel(II)-Histidine complex species Open
Nickel (Ni) is a trace heavy metal of importance in biological and environmental systems, with well documented allergy and carcinogenic effects in humans. With Ni(II) as the dominant oxidation state, the elucidation of the coordination mec…
View article: A proteomic profile of the healthy human placenta
A proteomic profile of the healthy human placenta Open
Background The placenta remains one of the least studied organs within the human body. Yet, placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long-term health conseq…
View article: Student teamwork in professional programmes in higher education: a comparative study of Spain and South Africa
Student teamwork in professional programmes in higher education: a comparative study of Spain and South Africa Open
Teamwork is a fundamental employability skill and, as such, is fostered in professional programmes. This study presents a comparative analysis of higher education students' perceptions, development, and experiences of teamwork at two unive…
View article: Faecal microbiota transplantation from Alzheimer’s participants induces impairments in neurogenesis and cognitive behaviours in rats
Faecal microbiota transplantation from Alzheimer’s participants induces impairments in neurogenesis and cognitive behaviours in rats Open
The gut microbiome is emerging as an important susceptibility factor in Alzheimer’s disease (AD) possibly due to the increased prevalence of pro-inflammatory genera in gut microbiota of AD participants. Microbiota-mediated changes in cogni…
View article: Preoperative pain measurements in correlation to deep endometriosis classification with Enzian. Deep endometriosis classification in relation to pain
Preoperative pain measurements in correlation to deep endometriosis classification with Enzian. Deep endometriosis classification in relation to pain Open
Background: Deep Endometriosis (DE) classification studies with Enzian never compared solitary (A, B, C, F), and combinations of anatomical locations (A&B, A&C, B&C, A&B&C), in correlation to pain. Therefore, the results of these studies a…
View article: Glycerophospholipid and detoxification pathways associated with small for gestation age pathophysiology: discovery metabolomics analysis in the SCOPE cohort
Glycerophospholipid and detoxification pathways associated with small for gestation age pathophysiology: discovery metabolomics analysis in the SCOPE cohort Open
Introduction Small for gestational age (SGA) may be associated with neonatal morbidity and mortality. Our understanding of the molecular pathways implicated is poor. Objectives Our aim was to determine the metabolic pathways involved in th…
View article: Anxiety, depression, and stress in response to the coronavirus disease-19 pandemic
Anxiety, depression, and stress in response to the coronavirus disease-19 pandemic Open
There are emotional indicators derived from the 2019 coronavirus pandemic in almost half of the study population. The identification and timely treatment of these states could lessen the psychological impact due to 2019 coronavirus.
View article: Adolescent-onset and adult-onset schizophrenia: reduced ribosomal protein expression via mTOR signalling in patient-derived olfactory cells
Adolescent-onset and adult-onset schizophrenia: reduced ribosomal protein expression via mTOR signalling in patient-derived olfactory cells Open
Schizophrenia is a heterogeneous disorder associated with many genetic and environmental risk factors that could affect brain development. It is unknown whether adolescent-onset and adult-onset schizophrenia have similar aetiology. To addr…
View article: Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia
Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia Open
L-Ergothioneine may help preserve mitochondrial function by increasing antioxidant levels, and reducing inflammatory responses associated with pre-eclampsia. This study shows the potential of L-Ergothioneine as a treatment for pre-eclampsi…
View article: Association between phospholipid metabolism in plasma and spontaneous preterm birth: a discovery lipidomic analysis in the cork pregnancy cohort
Association between phospholipid metabolism in plasma and spontaneous preterm birth: a discovery lipidomic analysis in the cork pregnancy cohort Open
Introduction Preterm birth (PTB) is defined as birth occurring before 37 weeks’ gestation, affects 5–9% of all pregnancies in developed countries, and is the leading cause of perinatal mortality. Spontaneous preterm birth (sPTB) accounts f…
View article: EQUSUM: Endometriosis QUality and grading instrument for SUrgical performance: proof of concept study for automatic digital registration and classification scoring for r-ASRM, EFI and Enzian
EQUSUM: Endometriosis QUality and grading instrument for SUrgical performance: proof of concept study for automatic digital registration and classification scoring for r-ASRM, EFI and Enzian Open
STUDY QUESTION Is electronic digital classification/staging of endometriosis by the EQUSUM application more accurate in calculating the scores/stages and is it easier to use compared to non-digital classification? SUMMARY ANSWER We develop…
View article: ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort
ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort Open
View article: Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children
Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Open
Our findings indicate that the lipidome and proteome of subjects who report PEs at 18 years of age are already altered at 12 years of age, indicating that metabolic dysregulation may contribute to an early vulnerability to PEs and suggesti…
View article: P1.16-34 The Impact of Pathology, Staging and Operative Resection on Survival and CT Evidence of Recurrence of Early NSCLC
P1.16-34 The Impact of Pathology, Staging and Operative Resection on Survival and CT Evidence of Recurrence of Early NSCLC Open
View article: 32.4 ALTERED COMPLEMENT PATHWAY PROTEIN EXPRESSION IS ASSOCIATED WITH PSYCHOTIC EXPERIENCES AT AGE 11 WHICH PERSIST AT AGE 18
32.4 ALTERED COMPLEMENT PATHWAY PROTEIN EXPRESSION IS ASSOCIATED WITH PSYCHOTIC EXPERIENCES AT AGE 11 WHICH PERSIST AT AGE 18 Open
The identification of early biomarkers of psychotic disorder is important because early treatment is associated with improved outcome. We have previously shown that altered complement and coagulation pathway associated proteins are associa…
View article: O1.1 ALTERED COMPLEMENT PATHWAY PROTEIN EXPRESSION IS ASSOCIATED WITH PSYCHOTIC EXPERIENCES AT AGE 11 WHICH PERSIST AT AGE 18
O1.1 ALTERED COMPLEMENT PATHWAY PROTEIN EXPRESSION IS ASSOCIATED WITH PSYCHOTIC EXPERIENCES AT AGE 11 WHICH PERSIST AT AGE 18 Open
The identification of early biomarkers of psychotic disorder is important because early treatment is associated with improved outcome. We have previously shown that altered complement and coagulation pathway associated proteins are associa…
View article: Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells Open
View article: Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort
Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort Open
The identification of early biological changes associated with the psychotic disorder (PD) is important as it may provide clues to the underlying pathophysiological mechanisms. We undertook the first proteomic profiling of blood plasma sam…
View article: 126. Altered Complement and Coagulation Cascade in Age 11 Children Precedes to the Onset of Psychotic Disorder
126. Altered Complement and Coagulation Cascade in Age 11 Children Precedes to the Onset of Psychotic Disorder Open
\nBackground: The identification of early biomarkers of psychotic disorder is important because early treatment is associated with improved outcome. In the current study, our objective was to identify peripheral protein biomarkers and unde…
View article: Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder
Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder Open
The postsynaptic density (PSD) contains a complex set of proteins of known relevance to neuropsychiatric disorders such as schizophrenia and bipolar disorder. We enriched for this anatomical structure in the anterior cingulate cortex of 16…
View article: Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells Open
View article: Dataset of mouse hippocampus profiled by LC–MS/MS for label-free quantitation
Dataset of mouse hippocampus profiled by LC–MS/MS for label-free quantitation Open
View article: Blood biomarker discovery in drug-free schizophrenia: the contribution of proteomics and multiplex immunoassays
Blood biomarker discovery in drug-free schizophrenia: the contribution of proteomics and multiplex immunoassays Open
Introduction: Recent evidence supports an association between systemic abnormalities and the pathology of psychotic disorders which has led to the search for peripheral blood-based biomarkers. Areas covered: Here, we summariz…
View article: Blood biomarker discovery in drug-free schizophrenia: the contribution of proteomics and multiplex immunoassays
Blood biomarker discovery in drug-free schizophrenia: the contribution of proteomics and multiplex immunoassays Open
Introduction: Recent evidence supports an association between systemic abnormalities and the pathology of psychotic disorders which has led to the search for peripheral blood-based biomarkers. Areas covered: Here, we summariz…