Jane E. Bourke
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View article: Paediatric Fever Management Practices and Antipyretic Use Among Doctors and Nurses in Australian Emergency Departments
Paediatric Fever Management Practices and Antipyretic Use Among Doctors and Nurses in Australian Emergency Departments Open
Objectives To examine variation in practice and adherence to international clinical guidelines for the management of fever among Australian Emergency Department (ED) clinicians. Methods Cross‐sectional survey across 22 Australian EDs. Clin…
View article: Silicosis research priorities for health care, research, and health and safety professionals, and for people exposed to silica in Australia: a research priority setting exercise
Silicosis research priorities for health care, research, and health and safety professionals, and for people exposed to silica in Australia: a research priority setting exercise Open
Objectives To identify the silicosis research priorities of people living with silicosis, workers at risk of silicosis, their partners and caregivers, and of health professionals and researchers. Study design Research priority setting exer…
View article: Generation of a novel lung fibrosis model using precision-cut lung slices from transgenic TGFβ1 mice
Generation of a novel lung fibrosis model using precision-cut lung slices from transgenic TGFβ1 mice Open
Induction of endogenous transforming growth factor β1, combined with factors increased in lungs of patients with lung fibrosis, in murine precision-cut lung slices provided an innovative ex vivo model for studying lung fibrosis. Leveraging…
View article: Human bone marrow mesenchymal stem cell-derived extracellular vesicles induce inverse dose-dependent anti-fibrotic effects in human myofibroblast cultures and bleomycin-injured mice with pulmonary fibrosis
Human bone marrow mesenchymal stem cell-derived extracellular vesicles induce inverse dose-dependent anti-fibrotic effects in human myofibroblast cultures and bleomycin-injured mice with pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a fatal condition associated with excessive interstitial collagen accumulation and irreversible lung function decline, for which there is no effective cure. Hence, this study evaluated the dose-depend…
View article: Lung-specific TGFβ overexpression increases airway fibrosis and airway contractility in transgenic mice
Lung-specific TGFβ overexpression increases airway fibrosis and airway contractility in transgenic mice Open
TGFβ upregulation is common in respiratory diseases. Here, the authors have utilized for the first time a mouse model of lung-specific overexpression of active TGFβ to demonstrate the dual role of TGFβ1 in structural remodeling and dysregu…
Pirfenidone Mitigates Transforming Growth Factor-β–induced Inflammation after Viral Infection Open
Infection by influenza A virus (IAV) and other viruses causes disease exacerbations in chronic obstructive pulmonary disease (COPD). Immune responses are blunted in COPD, a deficit compounded by current standard-of-care glucocorticosteroid…
View article: Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations
Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations Open
Revising public health policy based on new data does not happen automatically. This is acutely relevant to the now undeniable evidence that many diseases develop differently between the sexes and may also be affected by gender. Current hea…
View article: Patient-specific tracheal deformation, predicted toxicant uptake and histopathology in lung fibrosis
Patient-specific tracheal deformation, predicted toxicant uptake and histopathology in lung fibrosis Open
Background: Our simulations previously predicted focal areas of gaseous pollutant dose delivered to the airway mucosa of a patient with idiopathic pulmonary fibrosis (IPF). We hypothesize a relation between these dose predictions and clini…
View article: Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report
Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report Open
The urgent need for effective treatments for acute and chronic lung diseases underscores the significance of developing innovative preclinical human research tools. The 2023 American Thoracic Society Workshop on Precision-Cut Lung Slices (…
View article: Catch your breath: The protective role of the angiotensin AT2 receptor for the treatment of idiopathic pulmonary fibrosis
Catch your breath: The protective role of the angiotensin AT2 receptor for the treatment of idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease whereby excessive deposition of extracellular matrix proteins (ECM) ultimately leads to respiratory failure. While there have been advances in pharmacotherapies…
View article: The small‐molecule formyl peptide receptor biased agonist, compound 17b, is a vasodilator and anti‐inflammatory in mouse precision‐cut lung slices
The small‐molecule formyl peptide receptor biased agonist, compound 17b, is a vasodilator and anti‐inflammatory in mouse precision‐cut lung slices Open
Background and Purpose Pulmonary arterial hypertension (PAH), a rare fatal disorder characterised by inflammation, vascular remodelling and vasoconstriction. Current vasodilator therapies reduce pulmonary arterial pressure but not mortalit…
View article: Perspectives on precision cut lung slices—powerful tools for investigation of mechanisms and therapeutic targets in lung diseases
Perspectives on precision cut lung slices—powerful tools for investigation of mechanisms and therapeutic targets in lung diseases Open
Precision cut lung slices (PCLS) have emerged as powerful experimental tools for respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary airway contractility have been extended to pulmonary arteries and for as…
View article: The Role of the Interleukin-1 Family in Complications of Prematurity
The Role of the Interleukin-1 Family in Complications of Prematurity Open
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter i…
View article: Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung
Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung Open
SARS-CoV-2 infection causes a variety of physiological responses in the lung, and understanding how the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), and its proteolytic activator, transmembrane serine protease…
View article: Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia
Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia Open
Idiopathic pulmonary fibrosis is pathologically represented by usual interstitial pneumonia (UIP). Conventional bleomycin models used to study pathogenic mechanisms of pulmonary fibrosis display transient inflammation and fibrosis, so thei…
View article: Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant and epigenetic mechanisms
Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant and epigenetic mechanisms Open
Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the ovalbumin (OVA)-induced chronic allergic airways murine mod…
View article: Characterization of Epithelial Lesions and Patient-Specific Metrics of Airway Deformationto Assess the Impact of Inhaled Toxicants on Lung Mucosa in Fibrotic Lung Disease
Characterization of Epithelial Lesions and Patient-Specific Metrics of Airway Deformationto Assess the Impact of Inhaled Toxicants on Lung Mucosa in Fibrotic Lung Disease Open
Background/Aim: Discrete areas of epithelial damage and repair appear in the respiratory tract mucosa due to local effects of inhaled toxicants.These lesions are thought to play an important role in the initiation and exacerbation of chron…
View article: Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia
Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia Open
Idiopathic pulmonary fibrosis (IPF) is pathologically classified by usual interstitial pneumonia (UIP). Conventional bleomycin models used to study pathogenic mechanisms of pulmonary fibrosis display transient inflammation and fibrosis so …
View article: Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor
Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor Open
The CaSR is a class C G protein-coupled receptor (GPCR) that acts as a multimodal chemosensor to maintain diverse homeostatic functions. The CaSR is a clinical therapeutic target in hyperparathyroidism and has emerged as a putative target …
View article: RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD
RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD Open
Background The receptor for advanced glycation end products (RAGE) and Toll‐like receptor 4 (TLR4) is implicated in COPD. Although these receptors share common ligands and signalling pathways, it is not known whether they act in concert to…